Sensor-based evaluation of Circadian motor behavior in people with Dementia. Development and validation of analysis strategies

[ITA]La demenza consiste nel deterioramento, spesso progressivo, dello stato cognitivo di un individuo. Chi è affetto da demenza, presenta alterazioni a livello cognitivo, comportamentale e motorio, ad esempio compiendo gesti ossessivi, ripetitivi, senza uno scopo preciso. La condizione dei pazienti affetti da demenza è valutata clinicamente tramite apposite scale e le informazioni relative al comportamento vengono raccolte intervistando chi se ne occupa, come familiari, il personale infermieristico o il medico curante. Spesso queste valutazioni si rivelano inaccurate, possono essere fortemente influenzate da considerazioni soggettive, e sono dispendiose in termini di tempo. Si ha quindi l'esigenza di disporre di metodiche oggettive per valutare il comportamento motorio dei pazienti e le sue alterazioni patologiche; i sensori inerziali indossabili potrebbero costituire una valida soluzione, per questo scopo. L'obiettivo principale della presente attività di tesi è stato definire e implementare un software per una valutazione oggettiva, basata su sensori, del pattern motorio circadiano, in pazienti affetti da demenza ricoverati in un'unità di terapia a lungo termine, che potrebbe evidenziare differenze nei sintomi della malattia che interessano il comportamento motorio, come descritto in ambito clinico. Lo scopo secondario è stato quello di verificare i cambiamenti motori pre- e post-intervento in un sottogruppo di pazienti, a seguito della somministrazione di un programma sperimentale di intervento basato su esercizi fisici. --------------- [ENG]Dementia involves deterioration, often progressive, of a person's cognitive status. Those who suffer from dementia, present alterations in cognitive and motor behavior, for example performing obsessive and repetitive gestures, without a purpose. The condition of patients suffering from dementia is clinically assessed by means of specific scales and information relating to the behavior are collected by interviewing caregivers, such as the family, nurses, or the doctor. Often it turns out that these are inaccurate assessments that may be heavily influenced by subjective evaluations and are costly in terms of time. Therefore, there is the need for objective methods to assess the patients' motor behavior and the pathological changes; wearable inertial sensors may represent a viable option, so this aim. The main objective of this thesis project was to define and implement a software for a sensor-based assessment of the circadian motor pattern in patients suffering from dementia, hospitalized in a long-term care unit, which could highlight differences in the disease symptoms affecting the motor behavior, as described in the clinical setting. The secondary objective was to verify pre- and post-intervention changes in the motor patterns of a subgroup of patients, following the administration of an experimental program of intervention based on physical exercises.

State of the art and future perspectives on security metrics and their applications

In modern society, security issues of IT Systems are intertwined with interdisciplinary aspects, from social life to sustainability, and threats endanger many aspects of every- one’s daily life. To address the problem, it’s important that the systems that we use guarantee a certain degree of security, but to achieve this, it is necessary to be able to give a measure to the amount of security. Measuring security is not an easy task, but many initiatives, including European regulations, want to make this possible. One method of measuring security is based on the use of security metrics: those are a way of assessing, from various aspects, vulnera- bilities, methods of defense, risks and impacts of successful attacks then also efficacy of reactions, giving precise results using mathematical and statistical techniques. I have done literature research to provide an overview on the meaning, the effects, the problems, the applications and the overall current situation over security metrics, with particular emphasis in giving practical examples. This thesis starts with a summary of the state of the art in the field of security met- rics and application examples to outline the gaps in current literature, the difficulties found in the change of application context, to then advance research questions aimed at fostering the discussion towards the definition of a more complete and applicable view of the subject. Finally, it stresses the lack of security metrics that consider interdisciplinary aspects, giving some potential starting point to develop security metrics that cover all as- pects involved, taking the field to a new level of formal soundness and practical usability.

Feeding behaviour of the Corydoradinae

The evolution of a sub-family of south-american freshwater catfishes has created a great diversification of its representants into a huge number of species, usually members of characteristic mimicry communities. After the work of Alexandrou (Alexandrou, 2011) on the phylogeny of the group that discovered the existence of more deep divisions, from the taxonomic point of view, of the sub-family, even from the ecological point of view, I tried to reconfirm these statements from the ethological point of view, settling watching and recording sessions and an experiment that could show their interactions on the environment by observing their substrate mixing action.

Augmented Audiovisual Translation: the Perks and Perils of the Implementation of Artificial Intelligence in Subtitling and Dubbing

This thesis examines the state of audiovisual translation (AVT) in the aftermath of the COVID-19 emergency, highlighting new trends with regards to the implementation of AI technologies as well as their strengths, constraints, and ethical implications. It starts with an overview of the current AVT landscape, focusing on future projections about its evolution and its critical aspects such as the worsening working conditions lamented by AVT professionals – especially freelancers – in recent years and how they might be affected by the advent of AI technologies in the industry. The second chapter delves into the history and development of three AI technologies which are used in combination with neural machine translation in automatic AVT tools: automatic speech recognition, speech synthesis and deepfakes (voice cloning and visual deepfakes for lip syncing), including real examples of start-up companies that utilize them – or are planning to do so – to localize audiovisual content automatically or semi-automatically. The third chapter explores the many ethical concerns around these innovative technologies, which extend far beyond the field of translation; at the same time, it attempts to revindicate their potential to bring about immense progress in terms of accessibility and international cooperation, provided that their use is properly regulated. Lastly, the fourth chapter describes two experiments, testing the efficacy of the currently available tools for automatic subtitling and automatic dubbing respectively, in order to take a closer look at their perks and limitations compared to more traditional approaches. This analysis aims to help discerning legitimate concerns from unfounded speculations with regards to the AI technologies which are entering the field of AVT; the intention behind it is to humbly suggest a constructive and optimistic view of the technological transformations that appear to be underway, whilst also acknowledging their potential risks.

Deployment of a data analysis workflow of the ATLAS experiment on HPC systems

LHC experiments produce an enormous amount of data, estimated of the order of a few PetaBytes per year. Data management takes place using the Worldwide LHC Computing Grid (WLCG) grid infrastructure, both for storage and processing operations. However, in recent years, many more resources are available on High Performance Computing (HPC) farms, which generally have many computing nodes with a high number of processors. Large collaborations are working to use these resources in the most efficient way, compatibly with the constraints imposed by computing models (data distributed on the Grid, authentication, software dependencies, etc.). The aim of this thesis project is to develop a software framework that allows users to process a typical data analysis workflow of the ATLAS experiment on HPC systems. The developed analysis framework shall be deployed on the computing resources of the Open Physics Hub project and on the CINECA Marconi100 cluster, in view of the switch-on of the Leonardo supercomputer, foreseen in 2023.