On the role of AGN feedback in shaping galaxies across cosmic time

Understanding how Active Galactic Nuclei (AGN) shape galaxy evolution is a key challenge of modern astronomy. In the framework where black hole (BH) and galaxy growth are linked, AGN feedback must be tackled both at its “causes” (e.g. AGN-driven winds) and its “effects” (alteration of the gas reservoir in AGN hosts). The most informative cosmic time is z~1-3, at the peak of AGN activity and galaxy buildup, the so-called cosmic noon. The aim of this thesis is to provide new insights regarding some key questions that still remain open in this research field: i) What are the properties of AGN-driven sub-pc scale winds at z>1? ii) Are AGN-driven winds effective in influencing the life of galaxies? iii) Do AGN impact directly on star formation (SF) and gas content of their hosts? I first address AGN feedback as “caught in the act” by studying ultra-fast outflows (UFOs), X-ray AGN-driven winds, in gravitationally lensed quasars. I build the first statistically robust sample of high-z AGN, not preselected based on AGN-driven winds. I derive a first estimate of the high-z UFO detection fraction and measure the UFO duty cycle of a single high-z quasar for the first time. I also address the “effects” of AGN feedback on the life of host galaxies. If AGN influence galaxy growth, then they will reasonably impact the molecular gas reservoir first, and SF as a consequence. Through a comparative study of the molecular gas content in cosmic-noon AGN hosts and matched non-active galaxies (i.e., galaxies not hosting an AGN), we find that the host galaxies of more regular AGN (not selected to be the most luminous) are generally similar to non-active galaxies. However, we report on the possibility of a luminosity effect regulating the efficiency by which AGN might impact on galaxy growth.

Development and performance assessment of a Plasma Focus electron beam generator for Intra-Operative Radiation Therapy

The Plasma Focus is a device designed to generate a plasma sheet between two coaxial electrodes by means of a high voltage difference. The plasma is then driven to collapse into a “pinch”, where thermonuclear conditions prevail. During the “pinch phase” charged particles are emitted, with two main components: an ion beam peaked forward and an electron beam directed backward. The electron beam emitted backward by Plasma Focus devices is being investigated as a radiation source for medical applications, using it to produce x-rays by interaction with appropriate targets (through bremsstrahlung and characteristic emission). A dedicated Plasma Focus device, named PFMA-3 (Plasma Focus for Medical Applications number 3), has been designed, put in operation and tested by the research groups of the Universities of Bologna and Ferrara. The very high dose rate (several gray per discharge, in less than 1 µs) is a peculiarity of this device that has to be investigated, as it might modify the relative biological effectiveness (RBE). Aim of this Ph.D. project was to investigate the main physical properties of the low-energy x-ray beams produced by a Plasma Focus device and their potential medical applications to IORT treatments. It was necessary to develop the optimal geometrical configuration; to evaluate the x-rays produced and their dose deposited; to estimate the energy electron spectrum produced in the “pinch phase”; to study an optimal target for the conversion of the x-rays; to conduct simulations to study the physics involved; and in order to evaluate the radio-biological features of the beam, cell holders had to be developed for both irradiations and cell growth conditions.