Towards Unstructured Knowledge Integration in Natural Language Processing

In the last decades, Artificial Intelligence has witnessed multiple breakthroughs in deep learning. In particular, purely data-driven approaches have opened to a wide variety of successful applications due to the large availability of data. Nonetheless, the integration of prior knowledge is still required to compensate for specific issues like lack of generalization from limited data, fairness, robustness, and biases. In this thesis, we analyze the methodology of integrating knowledge into deep learning models in the field of Natural Language Processing (NLP). We start by remarking on the importance of knowledge integration. We highlight the possible shortcomings of these approaches and investigate the implications of integrating unstructured textual knowledge. We introduce Unstructured Knowledge Integration (UKI) as the process of integrating unstructured knowledge into machine learning models. We discuss UKI in the field of NLP, where knowledge is represented in a natural language format. We identify UKI as a complex process comprised of multiple sub-processes, different knowledge types, and knowledge integration properties to guarantee. We remark on the challenges of integrating unstructured textual knowledge and bridge connections with well-known research areas in NLP. We provide a unified vision of structured knowledge extraction (KE) and UKI by identifying KE as a sub-process of UKI. We investigate some challenging scenarios where structured knowledge is not a feasible prior assumption and formulate each task from the point of view of UKI. We adopt simple yet effective neural architectures and discuss the challenges of such an approach. Finally, we identify KE as a form of symbolic representation. From this perspective, we remark on the need of defining sophisticated UKI processes to verify the validity of knowledge integration. To this end, we foresee frameworks capable of combining symbolic and sub-symbolic representations for learning as a solution.

Advancing digital healthcare research and machine learning-aided knowledge extraction amidst the COVID-19 pandemic

The rapid progression of biomedical research coupled with the explosion of scientific literature has generated an exigent need for efficient and reliable systems of knowledge extraction. This dissertation contends with this challenge through a concentrated investigation of digital health, Artificial Intelligence, and specifically Machine Learning and Natural Language Processing's (NLP) potential to expedite systematic literature reviews and refine the knowledge extraction process. The surge of COVID-19 complicated the efforts of scientists, policymakers, and medical professionals in identifying pertinent articles and assessing their scientific validity. This thesis presents a substantial solution in the form of the COKE Project, an initiative that interlaces machine reading with the rigorous protocols of Evidence-Based Medicine to streamline knowledge extraction. In the framework of the COKE (“COVID-19 Knowledge Extraction framework for next-generation discovery science”) Project, this thesis aims to underscore the capacity of machine reading to create knowledge graphs from scientific texts. The project is remarkable for its innovative use of NLP techniques such as a BERT + bi-LSTM language model. This combination is employed to detect and categorize elements within medical abstracts, thereby enhancing the systematic literature review process. The COKE project's outcomes show that NLP, when used in a judiciously structured manner, can significantly reduce the time and effort required to produce medical guidelines. These findings are particularly salient during times of medical emergency, like the COVID-19 pandemic, when quick and accurate research results are critical.