Narratori degli anni zero. Storia, critica, poetiche

Il lavoro si propone come un’indagine sulla letteratura italiana del primo decennio del XXI secolo, in una prospettiva non di semplice ricognizione ma di individuazione di linee interpretative capaci di ripercorrere un archivio di materiali molto vasto e non ancora chiuso. La prima parte affronta questioni relative a condizioni produttive, ricezione e valutazione critica della letteratura contemporanea. Il primo capitolo è dedicato alla discussione di problemi relativi allo studio della narrativa italiana del XXI secolo a partire dalla definizione utilizzata per riferirsi ad essa, quella di “anni zero”. Il secondo capitolo situa la narrativa contemporanea nelle linee di sviluppo della letteratura italiana degli ultimi trent’anni, a partire da un mutamento del rapporto dello scrittore con la tradizione umanistica che risale all’inizio degli anni ottanta. Il terzo capitolo approfondisce uno dei generi maggiormente praticati: il romanzo storico. Considerato negli anni ottanta e novanta un genere d'evasione e intrattenimento, negli anni zero è divenuto veicolo di punti di vista critici nei confronti delle narrazioni dominanti. La seconda parte è dedicata all’approfondimento di romanzi che raccontano, da un’ottica non testimoniale, gli anni settanta italiani, periodo complesso non solo sul piano evenemenziale, ma anche su quello della rielaborazione artistica. I romanzi su cui si concentra l’indagine offrono un racconto degli anni settanta italiani a partire da un’idea di storia plurale, ricostruita attraverso una molteplicità di voci, che muta a seconda della prospettiva da cui viene affrontata. Le storie false dei romanzi sugli anni settanta non chiedono di essere lette come vere, ma dicono comunque qualcosa di vero sulle modalità attraverso le quali si va costruendo il rapporto con il passato recente, nel più ampio contesto dei percorsi della letteratura italiana di inizio millennio, tra spinte che vanno nella direzione del mantenimento dell’autonomia da parte degli autori e pressioni del mercato editoriale.

Colic surgery in the equine patient: novel biomarkers, postoperative management, microbiotal influence and epidemiological analysis on the italian territory

The aim of this work was to investigate novel diagnostic and prognostic tools, postoperative treatments and epidemiologic factors impacting the outcome of surgical cases of colic. To make a more accurate diagnosis and establish a prognosis, several biomarkers have been investigated in colic patients. In this study we evaluated peritoneal PCT and blood ADMA and SDMA in SIRS positive and negative colic patients to be used as prognostic biomarkers. Our results highlighted the limits of these biomarkers in detection and the lack of specificity. In fact PCT was not detectable and even if ADMA and SDMA significantly increased in colic horses, they are not diagnostic nor prognostic markers for SIRS. Fluid therapy has been described to be crucial for the outcome of colic patients, nevertheless no guidelines have been established. Overhydration was the common practice in post surgical management. We compared cases with an extended fluid therapy protocol and cases with a restricted protocol. Results showed that survival rate and postoperative complications were similar between the groups, despite costs being significantly lower in the restricted group. The possible correlation between intestinal microbiota and colics has gained interest. In this study, cecal and colonic content from horses undergoing laparotomy were collected, and the microbiota analized. Results showed some differences in microbiota between discharged and non discharged patients, and between strangulating and non strangulating types of colic, that might suggest some influence of hind gut microbiota on the disease. A multicentric study involving three veterinary teaching hospitals on the italian territory was conducted investigating factors affecting postoperative survival and complications in colics. Results showed that the influence of age, PCV, TPP, blood lactate, reflux, type of disease, type of lesion, presence of anastomosis, duration of surgery and surgeons, were in line with literature. Amount of crystalloids used could affected the outcome.

Insights on epidemiology and control of Marek’s disease through traditional and novel molecular tools

Marek's disease (MD) is a contagious, lymphoproliferative and neuropathic disease of poultry caused by a ubiquitous lymphotropic and oncogenic virus, Gallid alphaherpesvirus 2 (GaHV-2). MD has been reported in all poultry-rearing countries and is among the viral diseases with the highest economic impact in the poultry industry worldwide, including Italy. MD has been also recognized as one of the leading causes of mortality in backyard poultry. The present doctoral thesis aimed at exploring Marek's disease virus molecular epidemiology in Italian commercial and backyard chicken flocks and, for the first time, in commercial turkeys affected by clinical MD. Molecular biology techniques targeting the full-length meq gene, the major GaHV-2 oncogene, were used to detect and characterize the circulating GaHV-2 strains searching for genetic markers of virulence. A final study focused on the development of rapid, sensitive, and species-specific loop-mediated isothermal amplification assays coupled with a lateral flow device readout for the detection of conventional and recombinant HVT-based vaccines is included in the thesis. HVT vaccines, currently used to protect chickens from MD, are referred to as "leaky", as they do not impede the infection, replication, and shedding of field GaHV-2: vaccinal and field viruses can coexist in the vaccinated host and molecular tests able to discriminate between GaHV-2 and HVT are required. These new simple, fast, and accurate tests for the monitoring of MD vaccination success in the field could be greatly beneficial for field veterinarians, small laboratories, and more broadly for resource-limited settings.