L'Occidente di Elisée Reclus: l'invenzione dell'Europa nella Nouvelle Géographie Universelle (1876-1894)

La Nouvelle Géographie Universelle di Élisée Reclus relativizza e problematizza il ruolo dell’Europa e il suo peso nello scacchiere mondiale, restando tuttavia in equilibrio fra, da una parte, la critica delle pratiche coloniali e dall’altra la fiducia nei confronti della tradizione culturale proveniente dall’antica Grecia e dal secolo de Lumi destinata, nella visione evoluzionista dell’autore, a spargere negli altri continenti i germi del pensiero socialista e anarchico. In questo lavoro si cerca di chiarire questa rappresentazione dei concetti di Europa e Occidente in tre passaggi successivi. Dapprima, la ricostruzione della genealogia, della teoria e del contesto storico del concetto di geografia universale all’epoca. Poi, la ricostruzione dalle fonti di archivio delle reti scientifiche di respiro europeo che sono state alla base di quest’opera, indispensabile per poterne comprendere il significato politico nel contesto dell’epoca. Infine, l’indagine sul testo per ricostruire ruolo, caratteri e suddivisione dell’Europa, che si rivela, nonostante la serrata critica del suo ruolo colonizzatore, come il privilegiato laboratorio individuato dai “geografi anarchici” per lo sviluppo delle lotte sociali e per la costruzione, su basi anche geografiche, di una proposta politica federalista e libertaria.

Epigenetics of nutrition in aging

There is a need to identify factors that are able to influence health in old age and to develop interventions that could slow down the process of aging and its associated pathologies. Lifestyle modifications, and especially nutrition, appear to be promising strategies to promote healthy aging. Their impact on aging biomarkers has been poorly investigated. In the first part of this work, we evaluated the impact of a one-year Mediterranean-like diet, delivered within the framework of the NU-AGE project in 120 elderly subjects, on epigenetic age acceleration measures assessed with Horvath’s clock. We observed a rejuvenation of participants after nutritional intervention. The effect was more marked in the group of Polish females and in subjects who were epigenetically older at baseline. In the second part of this work, we developed a new model of epigenetic biomarker, based on a gene-targeted approach with the EpiTYPER® system. We selected six regions of interest (associated with ELOVL2, NHLRC1, SIRT7/MAFG, AIM2, EDARADD and TFAP2E genes) and constructed our model through a ridge regression analysis. In controls, estimation of chronological age was accurate, with a correlation coefficient between predicted and chronological age of 0.92 and a mean absolute deviation of 4.70 years. Our model was able to capture phenomena of accelerated or decelerated aging, in Down syndrome subjects and centenarians and offspring respectively. Applying our model to samples of the NU-AGE project, we observed similar results to the ones obtained with the canonical epigenetic clock, with a rejuvenation of the individuals after one-year of nutritional intervention. Together, our findings indicate that nutrition can promote epigenetic rejuvenation and that epigenetic age acceleration measures could be suitable biomarkers to evaluate their impact. We demonstrated that the effect of the dietary intervention is country-, sex- and individual-specific, thus suggesting the need for a personalized approach to nutritional interventions.