Celebración del Día del Libro (23 de abril de 2010) en el programa de radio Hoy por hoy

Emisión en directo, desde la Sala Polivalente del Edificio Central de la Biblioteca Universitaria del programa de radio de la cadena Ser "Hoy por hoy", el viernes 23 de abril de 2010, de 11.15 a 13 horas. Este programa estuvo dedicado al Día del libro y al servicio público que presta la Biblioteca Universitaria. Contó con la presencia de la Vicerrectora de Cultura y Deporte, doña Isabel Pascua Febles, la Directora de la Biblioteca Universitaria, doña María del Carmen Martín Marichal y los bibliotecarios Fernando Barrera Luján, María Dolores Orihuela Millares, Víctor Macías Alemán y Avelina Fernández Manrique de Lara. En la primera parte del programa se anunció a los ganadores del "Primer Premio de Relato Corto" organizado por la Biblioteca Universitaria de Las Palmas de Gran Canaria y se les hizo entrega de sus respectivos premios. El Primero recayó en la obra titulada "El Pacto" de Fernando Fernández Rodríguez, presentada bajo el seudónimo Agustín. El segundo lo obtuvo la obra "Subtítulo" de José Iván Rodríguez Macario firmado con el seudónimo León Miranda. Ambos premios serán incluidos en el Repositorio Institucional Acceda.

Contribuciones a la gestión de los recursos radio en redes móviles celulares de radio paquetes con soporte de calidad de servicio

Programa de doctorado: Tecnología de las Telecomunicaciones

Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs)

[EN] Head and neck cancer is treated mainly by surgery and radiotherapy. Normal tissue toxicity due to x-ray exposure is a limiting factor for treatment success. Many efforts have been employed to develop predictive tests applied to clinical practice. Determination of lymphocyte radio-sensitivity by radio-induced apoptosis arises as a possible method to predict tissue toxicity due to radiotherapy. The aim of the present study was to analyze radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients and to explore their role in predicting radiation induced toxicity. Seventy nine consecutive patients suffering from head and neck cancer, diagnosed and treated in our institution, were included in the study. Toxicity was evaluated using the Radiation Therapy Oncology Group scale. Peripheral blood lymphocytes were isolated and irradiated at 0, 1, 2 and 8 Gy during 24 hours. Apoptosis was measured by flow cytometry using annexin V/propidium iodide. Lymphocytes were marked with CD45 APC-conjugated monoclonal antibody. Radiation-induced apoptosis increased in order to radiation dose and fitted to a semi logarithmic model defined by two constants: α and β. α, as the origin of the curve in the Y axis determining the percentage of spontaneous cell death, and β, as the slope of the curve determining the percentage of cell death induced at a determined radiation dose, were obtained. β value was statistically associated to normal tissue toxicity in terms of severe xerostomia, as higher levels of apoptosis were observed in patients with low toxicity (p = 0.035; Exp(B) 0.224, I.C.95% (0.060-0.904)). These data agree with our previous results and suggest that it is possible to estimate the radiosensitivity of peripheral blood lymphocytes from patients determining the radiation induced apoptosis with annexin V/propidium iodide staining. β values observed define an individual radiosensitivity profile that could predict late toxicity due to radiotherapy in locally advanced head and neck cancer patients. Anyhow, prospective studies with different cancer types and higher number of patients are needed to validate these results.