Dietary intake of environmentally persistent plaguicides in the european population

[EN] Global pollution has become one of the most important problems of the modern societies and pesticides play a major role among the chemical contaminants that are released to the environment every year. Organochlorine compounds have been widely used in the past all over the world as pesticides and some of them are still used for the control of vectors of infectious diseases. Due to their high lipophilicity, stability and resistance to degradation, most of them have been banned or strictly regulated but their levels remain high in the environment as persistent organic pollutants (POPs). Their presence in the environment leads to their introduction into the food chain, especially affecting food of animal origin with higher fat content. Due to their liposolubility, these substances tend to be bioaccumulated into the fat tissues of living beings along their entire lives, and to be biomagnificated across trophic levels in the food chain. Thus, the main human source of these pesticides comes from the daily intake of contaminated food from environmental sources. It has been established the role of many of the POPs as endocrine disruptors and even as carcinogenic agents, being thus considered as important risk factors for health. Moreover, chronic exposure to pesticides, even at very low levels, has been related with cancer, fertility problems, immunosuppression and other diseases. For this reason, it is important to know the level of POPs contamination and to identify the main sources contributing to it. Fish, meat and dairy products are the food groups with the highest levels of pollution. However, the residue levels vary by geographic area, and are influenced by several factors as food security policies, local pesticide use patterns, environmental practices, or the time when the study is conducted. Food habits, conditioned by different social and economic factors, as well as several biological factors (i.e. gender, sex and age), determine the levels of POPs exposure in the population. The purpose of this chapter is to give an overview of the dietary intake of environmentally persistent pesticides by the European population, and the potential adverse consequences of this exposure on human health.

Contaminantes tóxicos persistentes: nivel de exposición de la población canaria a través del consumo de productos lácteos

Programa de doctorado: Clínica e investigación terapéutica.

Mixtificaciones. Reciclajes Urbanos

[ES] El siguiente trabajo se centra en el extremo norte del Polígono de Viviendas de la Vega de San Jose, en las Palmas de Gran canaria, un área residencial que representa bien el estado comun de deterioro y problemática social de estos barrios construidos en nuestras ciudades durante los años 60/70. En muchos casos los desfases entre las necesidades de aquellos años y las condiciones actuales ha dejado a esa importante población habitante de los polígonos en condiciones de habitabilidad y desarrollo social inadecuados".La propuesta nace de la necesidad de "liberar" espacio en el lugar,optar por un consumo mínimo del suelo, actualmente es un lugar donde no existen espacios libres o areas verdes como tal, el uso excesivo del coche en el sitio conlleva a la falta de implicación del usuario con los mismos, para ello se limita el uso del coche a un anillo perimetral en el que se plantean "bolsas de aparcamientos" que estarán conectadas directamente con la zona de actuación. Para un menor consumo del suelo, nace la idea de crear una CIUDAD ESPACIAL, estructuras tridimensionales que se apoyan en las edificaciones existentes para su desarrollo; liberando de esta forma la planta baja y dotando el lugar de un gran espacio verde de realaciones-actividades, crear un "pulmon" en el lugar. Planteo por tanto rehabilitar lo existente, reconstruir y mejorar las edificaciones que han quedado obsoletas con el paso del tiempo y aportarle las distintas necesidades que han ido surgiendo y que surgiran; pensar en un sistema de crecimiento mas que en una solución inmediata, si planteamos esas estructuras flotantes la ciudad podra seguir avanzando y generando espacios nuevos en la misma, sin tener que optar por un mayor consumo del suelo. Este tipo de intervención es adaptable a cualquier soporte urbano, ya que parte de dos principios fundamentales, pensar en las necesidades de los habitantes y mejorar la calidad espacial de las ciudades existentes.

Complex organochlorine pesticide mixtures as determinant factor for breast cancer risk: a population-based case-control study in the Canary Islands (Spain)

[EN] Background: All the relevant risk factors contributing to breast cancer etiology are not fully known. Exposure to organochlorine pesticides has been linked to an increased incidence of the disease, although not all data have been consistent. Most published studies evaluated the exposure to organochlorines individually, ignoring the potential effects exerted by the mixtures of chemicals. Methods: This population-based study was designed to evaluate the profile of mixtures of organochlorines detected in 103 healthy women and 121 women diagnosed with breast cancer from Gran Canaria Island, and the relation between the exposure to these compounds and breast cancer risk.Results: The most prevalent mixture of organochlorines among healthy women was the combination of lindane and endrin, and this mixture was not detected in any affected women. Breast cancer patients presented more frequently a combination of aldrin, dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD), and this mixture was not found in any healthy woman. After adjusting for covariables, the risk of breast cancer was moderately associated with DDD (OR = 1.008, confidence interval 95% 1.001-1.015, p = 0.024).Conclusions: This study indicates that healthy women show a very different profile of organochlorine pesticide mixtures than breast cancer patients, suggesting that organochlorine pesticide mixtures could play a relevant role in breast cancer risk.

Relationship between body image disturbance and incidence of depression: the SUN prospective cohort

[EN] Background: Body image disturbance is an increasing problem in Western societies and is associated with a number of mental health outcomes including anorexia, bulimia, body dysmorphia, and depression. The aim of this study was to assess the association between body image disturbance and the incidence of depression. Methods: This study included 10,286 participants from a dynamic prospective cohort of Spanish university graduates, who were followed-up for a median period of 4.2 years (Seguimiento Universidad de Navarra – the SUN study). The key characteristic of the study is the permanently open recruitment that started in 1999. The baseline questionnaire included information about body mass index (BMI) and the nine figure schemes that were used to assess body size perception. These variables were grouped according to recommended classifications and the difference between BMI and body size perception was considered as a proxy of body image disturbance. A subject was classified as an incident case of depression if he/she was initially free of depression and reported a physician-made diagnosis of depression and/or the use of antidepressant medication in at least one of the follow-up questionnaires. The association between body image disturbance and the incidence of depression was estimated by calculating the multivariable adjusted Odds Ratio (OR) and its 95% Confidence Interval (95% CI), using logistic regression models. Results: The cumulative incidence of depression during follow-up in the cohort was 4.8%. Men who underestimated their body size had a high percentage of overweight and obesity (50.1% and 12.6%, respectively), whereas women who overestimated their body size had a high percentage of underweight (87.6%). The underestimation exhibited a negative association with the incidence of depression among women (OR: 0.72, 95% CI: 0.54 – 0.95), but this effect disappeared after adjusting for possible confounding variables. The proportion of participants who correctly perceived their body size was high (53.3%) and gross misperception was seldom found, with most cases selecting only one silhouette below (42.7%) or above (2.6%) their actual BMI. Conclusion: We found no association between body image disturbance and subsequent depression in a cohort of university graduates in Spain.

Morphogenesis of the Ourense plains:(NW of Spain)

[EN] We present a geomorphological analysis of Ourense Province (NW Spain) characterized by: a general narrowing of the fluvial network, highlands with smooth reliefs partially eroded and lowlands with residual reliefs, several extensive plains of erosion frequently limited by fractures -among which Tertiary grabens are inserted-, some ?Hollow Surface?-type morphology, absence of sedimentary deposits outside the grabens, and a generalized outcrop of the Hercynian Massif substratum. Traditionally, this ?piano?s keyboard morphology? has been interpreted as expression of block tectonics in tensile regimen; instead we suggest the existence of: an isostatic upheaval simultaneous to a sequence of tectonic pulses of compressive regimen with activity in favour of transcurrent faults, a General Surface (R600), several plains that present a ?Hollow Surface?-type morphology (R1600 R1400 R1000), a generalized alteration that correspond to a same process of decomposition associated to fluctuating conditions of redox equilibrium, a erosional terraces related principaly to the palaeo-fluvial nets; moreover, we propose the existence of two morphoestructural lineament: the first one represented by the Fault of Vila Real (NE-SW) -a ramification of the ?Basal Pyrenean Overthrust?-, that would have been active at an early moment of the tectonic sequence with a left transcurrent fault, secondly the lineament represented by the Fault of Maceda (NNW-SSE) that would be related to the ?Fault System NW-SE? and would have produced a right transcurrent fault during a late tectonic pulse.

Nuevas investigaciones en torno a los grabados rupestres del Barranco de Balos (Agüimes, Gran Canaria)

[ES] Thirty six years have happened since A. Beltrán carried the first study out in depth of the archaeological area of the Massif of Balos. A study that adheres strictly to this emplacement, without never one alludes to the cultural context of these representations or to the existence of other sets in the same space. The recent studies have made clear not only that the Lomo de los Letreros is not the only rock existing station in this territory but in the same one there is located a nourished representation of places that award to this place an unusual interest to realize an approach to the meaning of this pre-hispanic engravings.