Investigació i pesca

Conferencia pronunciada al Saló Fontana d'or de Girona, el Dilluns, día 6 de Maig, a l'acte solemne en honor de Sant Isidor

MVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapy

[EN] Objective: To explore the role of Major Vault Protein (MVP) in oral cavity squamous cell carcinoma patients. Subjects and Methods: 131 consecutive patients suffering from oral cavity squamous cell carcinoma were included in the study. In the whole series, the mean follow-up for survivors was 123.11 ± 40.36 months. Patients in tumour stages I and II were referred to surgery; patients in stage III-IV to postoperative radiotherapy (mean dose = 62.13 ± 7.74 Gy in 1.8–2 Gy/fraction). MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue. Results: MVP expression was positive in 112 patients (85.5%) and no relation was found with clinic pathological variables. MVP overexpression (those tumours with moderate or strong expression of the protein) was related to insulin-like growth factor receptor-1 (IGF-1R) expression (P = 0.014). Tumour stage of the disease was the most important prognostic factor related to survival. Tumours overexpressing MVP and IGF-1R were strongly related to poor disease-free survival (P = 0.008, Exp(B) = 2.730, CI95% (1.302-5.724)) and cause-specific survival (P = 0.014, Exp(B) = 2.570, CI95% (1.215-5.437)) in patients achieving tumour stages III-IV, in multivariate analysis. Conclusions: MVP and IGF-1R expression were related in oral squamous cell carcinoma and conferred reduced long-term survival in patients suffering from advanced stages of the disease.

I Taller de Innovación Educativa de la Escuela de Ingenierías Industriales y Civiles

[ES]Los resúmenes que se incluyen en esta publicación corresponden a las presentaciones efectuadas en el Taller de Innovación Educativa de la Escuela de Ingenierías Industriales y Civiles, llevado a cabo los meses de junio y julio de 2015. Dicho taller estuvo dirigido al personal docente de la Escuela, con objeto de que conocieran de primera mano las experiencias docentes innovadoras llevadas a cabo por compañeros profesores que imparten docencia tanto en la propia Escuela como en otros centros de esta Universidad. Durante las sesiones los participantes tuvieron la oportunidad de compartir los resultados de distintas iniciativas docentes desarrolladas en asignaturas relacionadas con la ingeniería, así como de conocer nuevas técnicas de apoyo al proceso de enseñanza-aprendizaje.