33 resultados para Olivari, Nicolás
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Editorial: Una oferta europea. Actualidad Institucional: Nueve Posgrados oficiales adaptados a Europa. Abierta la preinscripción para alumnos de nuevo ingreso. Entrevista: Nicolás Díaz-Saavedra de Morales. Abogado y ex político, es uno de los protagonistas del importante grupo de personas que demandaron y lucharon por la creación de una universidad autónoma y completa en Gran Canaria. La ULPGC investiga: Creado un dispositivo para la identificación por infrarrojos. Nuevo sistema de cultivo que permite regar con agua de mar. Comunidad Universitaria: Viaje al Sáhara de los alumnos de Geografía. Un estudiante, becado en el Centro Europeo de Investigación Nuclear. Agenda
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Programa de doctorado: Avances en medicina interna.
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Programa de doctorado: Cáncer: biología y clínica.
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[EN] The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGN(n), polyglycine) or its transcriptional activity (CAG(n), polyglutamine). Shorter CAG and/or GGN repeats provide stronger androgen signalling and vice versa. To test the hypothesis that CAG and GGN repeat AR polymorphisms affect muscle mass and various variables of muscular strength phenotype traits, the length of CAG and GGN repeats was determined by PCR and fragment analysis and confirmed by DNA sequencing of selected samples in 282 men (28.6 +/- 7.6 years). Individuals were grouped as CAG short (CAG(S)) if harbouring repeat lengths of 21. GGN was considered short (GGN(S)) or long (GGN(L)) if GGN 23, respectively. No significant differences in lean body mass or fitness were observed between the CAG(S) and CAG(L) groups, or between GGN(S) and GGN(L) groups, but a trend for a correlation was found for the GGN repeat and lean mass of the extremities (r=-0.11, p=0.06). In summary, the lengths of CAG and GGN repeat of the AR gene do not appear to influence lean mass or fitness in young men.