1 resultado para Age 15 Years
em Academic Archive On-line (Stockholm University
Filtro por publicador
- Academic Archive On-line (Jönköping University; Sweden) (3)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- Aquatic Commons (9)
- ARCA - Repositório Institucional da FIOCRUZ (1)
- Archive of European Integration (5)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Aston University Research Archive (13)
- B-Digital - Universidade Fernando Pessoa - Portugal (2)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (22)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (2)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (7)
- Bioline International (6)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (96)
- Brock University, Canada (5)
- CentAUR: Central Archive University of Reading - UK (9)
- Center for Jewish History Digital Collections (1)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (4)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Dalarna University College Electronic Archive (3)
- Deakin Research Online - Australia (80)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (3)
- Digital Commons - Montana Tech (1)
- Digital Commons at Florida International University (9)
- DigitalCommons@The Texas Medical Center (19)
- Duke University (3)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (18)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (3)
- Helda - Digital Repository of University of Helsinki (15)
- Hospitais da Universidade de Coimbra (1)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico de Santarém (1)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (2)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Publishing Network for Geoscientific & Environmental Data (10)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (54)
- Queensland University of Technology - ePrints Archive (189)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- REPOSITÓRIO ABERTO do Instituto Superior Miguel Torga - Portugal (5)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (3)
- Repositório Científico do Instituto Politécnico de Santarém - Portugal (1)
- Repositorio de la Universidad de Cuenca (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (2)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (2)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (1)
- Repositório Institucional dos Hospitais da Universidade Coimbra (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (105)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Scielo España (1)
- Scientific Open-access Literature Archive and Repository (1)
- Universidad del Rosario, Colombia (22)
- Universidad Politécnica de Madrid (3)
- Universidade Complutense de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade de Madeira (1)
- Universidade Federal do Pará (9)
- Universidade Federal do Rio Grande do Norte (UFRN) (12)
- Universidade Metodista de São Paulo (7)
- Universitat de Girona, Spain (2)
- Université de Lausanne, Switzerland (6)
- Université de Montréal (3)
- Université de Montréal, Canada (11)
- University of Michigan (7)
- University of Queensland eSpace - Australia (18)
- University of Washington (4)
- WestminsterResearch - UK (1)
Resumo:
We investigated whether a physiological marker of cardiovascular health, pulse pressure (PP), and age magnified the effect of the functional COMT Val158Met (rs4680) polymorphism on 15-years cognitive trajectories [episodic memory (EM), visuospatial ability, and semantic memory] using data from 1585 non-demented adults from the Betula study. A multiple-group latent growth curve model was specified to gauge individual differences in change, and average trends therein. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val158Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by statistical control for PP. Further, PP moderated the effects of COMT on 15-years EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (diabetes, stroke, and hypertension), and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in normal cognitive aging, as the addition thereof may place healthy individuals at greater risk for memory decline.