1 resultado para Inducers of resistance
em Universidade Federal do Pará
Filtro por publicador
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- Aquatic Commons (3)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (3)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Aston University Research Archive (34)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (16)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (9)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bioline International (5)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (48)
- Boston University Digital Common (1)
- Brock University, Canada (10)
- CaltechTHESIS (2)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (55)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (7)
- Cochin University of Science & Technology (CUSAT), India (3)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (8)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Deakin Research Online - Australia (68)
- Digital Commons - Michigan Tech (4)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (10)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (21)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (6)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (67)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Glasgow Theses Service (3)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (5)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (36)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico do Porto, Portugal (3)
- National Center for Biotechnology Information - NCBI (52)
- Portal de Revistas Científicas Complutenses - Espanha (4)
- Publishing Network for Geoscientific & Environmental Data (1)
- QSpace: Queen's University - Canada (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (82)
- Queensland University of Technology - ePrints Archive (65)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (2)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (10)
- Repositório Institucional da Universidade de Aveiro - Portugal (3)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (138)
- Research Open Access Repository of the University of East London. (4)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- SAPIENTIA - Universidade do Algarve - Portugal (3)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (2)
- Universidad Politécnica de Madrid (3)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade do Algarve (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (2)
- Universidade Federal do Pará (1)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Lausanne, Switzerland (1)
- Université de Montréal (3)
- Université de Montréal, Canada (11)
- University of Michigan (4)
- University of Queensland eSpace - Australia (24)
- University of Washington (2)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Resistance of Helicobacter pylori to clarithromycin is characterised by simple point mutations in the 23S ribosomal RNA (rRNA) gene and is responsible for the majority of cases of failure to eradicate this bacterium. In this paper, we characterised the variability of the 23S rRNA gene in biopsies of patients with gastric pathologies in the eastern Amazon (Northern Region of Brazil) using PCR and sequencing. A total of 49 sequences of H. pylori strains were analysed and of those, 75.6% presented nucleotide substitutions: A2142G (3.3%), T2182C (12.9%), G2224A (6.45%), T2215C (61.3%), A2192G (3.3%), G2204C (6.4%) and T2221C (6.4%). Of the mutations identified, four are known mutations related to cases of resistance and 16.1% are not yet described, revealing a high prevalence of mutations in the H. pylori 23S rRNA gene among the strains circulating in the in the eastern Amazon. The high prevalence in individuals with gastric pathologies in the Northern Region of Brazil demonstrates the need for characterising the profile of these strains to provide correct therapy for patients, considering that mutations in this gene are normally associated with resistance to the primary medication used in controlling H. pylori infection.