A natural combinatorial chemistry strategy in acylpolyamine toxins from Nephilinae orb-web spiders

The present study shows how nature combined a small number of chemical building blocks to synthesize the acylpolyamine toxins in the venoms of Nephilinae orb-web spiders. Considering these structures in four parts, it was possible to rationalize a way to represent the natural combinatorial chemistry involved in the synthesis of these toxins: an aromatic moiety is connected through a linker amino acid to a polyamine chain, which in turn may be connected to an optional tail. The polyamine chains were classified into seven subtypes (from A to G) depending on the way the small chemical blocks are combined. These polyamine chains may be connected to one of the three possible chromophore moieties: 2,4-dihydroxyphenyl acetic acid, or 4-hydroxyindole acetic acid, or even with the indole acetic group. The connectivity between the aryl moiety and the polyamine chain is usually made through an asparagine residue; optionally a tail may be attached to the polyamine chain; nine different types of tails were identified among the 72 known acylpolyamine toxin structures. The combinations of three chromophores, two types of amino acid linkers, seven sub-types of polyamine backbone, and nine options of tails results in 378 different structural possibilities. However, we detected only 91 different toxin structures, which may represent the most successful structural trials in terms of efficiency of prey paralysis/death.

SISTAX - An intelligent tool for recovering information on natural products chemistry

This work describes the development of a new program, named SISTAX, for the expert system SISTEMAT. This program allows anyone interested in chemotaxonomy to carry out an intelligent search for organic compounds in databases through chemical structures. When coupled with can efficient encoding system, the program recognizes skeletal types and can find any substructural constraints demanded by the user. An example of an application of the program to the diterpene class found in plants is described.

Interdisciplinaridade: concepções de professores da área ciências da natureza em formação em serviço

O objetivo do presente estudo foi investigar como os docentes da área de Ciências Naturais concebem o conceito de interdisciplinaridade e de que forma desenvolveriam um trabalho interdisciplinar a partir de um tema comum sugerido: o Efeito Estufa. Através de questionários dissertativos, os professores-alunos participantes de um projeto de formação em serviço (Pró-Ciências), expressaram suas concepções iniciais a respeito do tema. A análise das respostas obtidas levou-nos às seguintes conclusões: os professores entrevistados têm apenas concepções rudimentares de interdisciplinaridade e confundem este conceito com o de multidisciplinaridade. Afirmam que é possível trabalhar o conceito de Efeito Estufa de maneira interdisciplinar, mas não indicam metodologias adequadas para fazê-lo, devido à carência conceitual apontada anteriormente.

Mechanical behavior of natural fiber composites

The use of natural fibers as reinforcement in polymeric composites for technical applications has been a research subject of scientists during the last decade. There is a great interest in the application of sisal fiber as substitutes for glass fibers, motivated by potential advantages of weight saving, lower raw material price, and ecological advantages of using green resources which are renewable and biodegradable.Castor oil, a triglyceride vegetable that has hydroxyl groups, was reacted with 4,4' diphenylmethane diisocyanate (MDI) to produce the polyurethane matrix. Woven sisal fibers were used untreated and thermal treated at 60 C for 72h, and the composites were processed by compression molding.The present work study tensile behavior at four composites: dry sisal/polyurethane, humid sisal/polyurethane, dry sisal/phenolic and humid sisal/phenolic resin. The moisture content influences of sisal fibers on the mechanical behaviors were analyzed.Experimental results showed a higher tensile strength for the sisal/phenolic composites followed by sisal/polyurethane, respectively. In this research, sisal composites were also characterized by scanning electron microscopy. (C) 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of ICM11

Formação continuada na perspectiva da racionalidade comunicativa: possibilidades de articulação entre literatura infantil e o ensino de ciências da natureza

Pós-graduação em Educação para a Ciência - FC

Ensino e aprendizagem de avaliação funcional descritiva na atuação profissional de professores de ciências no ensino fundamental

Pós-graduação em Educação para a Ciência - FC

O cientificismo como obstáculo à compreensão ético-política da Psicologia

In separating the phenomena of their social, human, and ecological contexts, and by not taking into account intentional and valorative categories, natural-scientific methodologies impede the comprehension of some human activities which include values, chiefly ethical and political. In this context, scientism is the dogmatic and non-thematized acceptance of natural-scientific methods. From this point on, in the context of psychology, the aim of this paper is to demonstrate how scientism can function as an epistemological and methodological obstacle to an ethical and political understanding of psychology. Thus, at first, through reflections based on problems encountered in the literature on the subject, scientism's dogmas and some counterpoints are presented; some of its consequences are addressed, by taking up two examples from current literature - the labeling and the racial interpretations, and, finally, a program of research which deals with these problems is presented as an alternative: critical psychology.

Educação ambiental e educação em valores em livros didáticos de ciências naturais

Os valores têm sido considerados importante conteúdo de ensino, sobretudo ao tratarmos de certas temáticas, como a ambiental. Procurando analisar o tratamento dado à dimensão valorativa da temática ambiental em três coleções de Ciências Naturais voltadas às séries finais do Ensino Fundamental verificamos a predominância da visão antropocêntrica, sendo a natureza valorizada em função de sua utilidade para o ser humano. O predomínio da valorização do conhecimento científico em detrimento de outras formas de conhecimento, da ação humana individual em detrimento da coletiva e a simples apresentação de leis ambientais foram outros aspectos problemáticos encontrados. Uma das coleções, entretanto, além de valorizar o trabalho coletivo dos alunos, também se destacou pela maior ênfase dada à dimensão estética, implicando uma visão de mundo menos utilitarista e um tratamento mais adequado do conteúdo valorativo da temática ambiental.

Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae

In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 mu g of glucan by i.p. route, were assayed. In vivo mu-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work.

APPLICATIONS OF ARTIFICIAL-INTELLIGENCE IN ORGANIC-CHEMISTRY .17. NEW PROGRAMS IN THE SISTEMAT PROJECT

This work describes the new improvements of the SISTEMAT project, one system for structural elucidation mainly in the field of Natural Products Chemistry. Some examples of the resolution of problems using C-13 Nuclear Magnetic Resonance and Mass Spectroscopy are given. Programs to discover new heuristic rules for structure generation are discussed. The data base contains about 10000 C-13 NMR spectra.

Effects of food quality on growth and biochemical composition of a calanoid copepod, Argyrodiaptomus furcatus, and its importance as a natural food source for larvae of two tropical fishes

Growth, reproduction and biochemical composition were analyzed for the copepod Argyrodiaptomus furcatus fed on the alga Ankistrodesmus gracilis grown in different media. The ingestion of this copepod by larvae of two species of tropical fishes was also evaluated. The mean peak density of the copepod population was 1369 individuals 1-1 for all four diets used, and the highest was 1387 individuals 1-1 on diet ARV (algae + ration + vitamins). A small copepod, A. furcatus tends to have a short life span. The smallest females did not attain maturity in the shortest time on all diets used. Food quality may play a major role in the dynamics of the biochemical composition of this copepod. Argyrodiaptomus furcatus was a more important food item for larvae of tambaqui (Colossoma macropomum) than of pacu (Piaractus mesopotamicus). However, it made up a large part of the gut contents of larvae of both species.

Interplanetary natural routes via Moon and Lagrangiam points L1 and L2

Swing-by techniques are extensively used in interplanetary missions to minimize fuel consumption and to raise payloads of spaceships. The effectiveness of this type of maneuver has been proven since the beginning of space exploration. According to this premise, we have explored the existence of a natural and direct links between low Earth orbits and the lunar sphere of influence, to obtain low-energy interplanetary trajectories through swing-bys with the Moon and the Earth. The existence of these links are related to a family of retrograde periodic orbits around the Lagrangian equilibrium point L1 predicted for the circular, planar, restricted three-body Earth-Moon-particle problem. The trajectories in these links are sensitive to small disturbances. This enables them to be conveniently diverted reducing so the cost of the swing-by maneuver. These maneuvers allow us a gain in energy sufficient for the trajectories to escape from the Earth-Moon system and to stabilize in heliocentric orbits between the Earth and Venus or Earth and Mars. On the other hand, still within the Earth sphere of influence, and taking advantage of the sensitivity of the trajectories, is possible to design other swing-bys with the Earth or Moon. This allows the trajectories to have larger reach, until they can reach the orbit of other planets as Venus and Mars.(3σ)Broucke, R.A., Periodic Orbits in the Restricted Three-Body Problem with Earth-Moon Masses, JPL Technical Report 32-1168, 1968.

Dez anos dos Parâmetros Curriculares Nacionais: contribuições para o ensino de ciências naturais nos anos iniciais do ensino fundamental I

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)