Application of molecular markers on genetic improvement and reproduction in the post-genomic Era: Emerging biotechnologies and perspectives in livestock

Background: New challenges are rising in the animal protein market, and one of the main world challenges is to produce more in shorter time, with better quality and in a sustainable way. Brazil is the largest beef exporter in volume hence the factors affecting the beef meat chain are of major concern in countrýs economy. An emerging class of biotechnological approaches, the molecular markers, is bringing new perspectives to face these challenges, particularly after the publication of the first complete livestock genome (bovine), which has triggered a massive initiative to put in practice the benefits of the so called the Post-Genomic Era. Review: This article aimed at showing the directions and insights in the application of molecular markers on livestock genetic improvement and reproduction as well at organizing the progress so far, pointing some perspectives of these emerging technologies in Brazilian ruminant production context. An overview on the nature of the main molecular markers explored in ruminant production is provided, which describes the molecular bases and detection approaches available for microsatellites (STR) and single nucleotide polymorphisms (SNP). A topic is dedicated to review the history of association studies between markers and important trait variation in livestock, showing the timeline starting on quantitative trait loci (QTL) identification using STR markers and ending in high resolution SNP panels to proceed whole genome scans for phenotype/genotype association. Also the article organizes this information to reveal how QTL prospection using STR could open ground to the feasibility of marker-assisted selection and why this approach is quickly being replaced by studies involving the application of genome-wide association using SNP research in a new concept called genomic selection. Conclusion: The world's scientific community is dedicating effort and resources to apply SNP information in livestock selection through the development of high density panels for genomic association studies, connecting molecular genetic data with phenotypes of economic interest. Once generated, this information can be used to take decisions in genetic improvement programs by selecting animals with the assistance of molecular markers.

Triplet entropy analysis of hemagglutinin and neuraminidase sequences measures influenza virus phylodynamics

The influenza virus has been a challenge to science due to its ability to withstand new environmental conditions. Taking into account the development of virus sequence databases, computational approaches can be helpful to understand virus behavior over time. Furthermore, they can suggest new directions to deal with influenza. This work presents triplet entropy analysis as a potential phylodynamic tool to quantify nucleotide organization of viral sequences. The application of this measure to segments of hemagglutinin (HA) and neuraminidase (NA) of H1N1 and H3N2 virus subtypes has shown some variability effects along timeline, inferring about virus evolution. Sequences were divided by year and compared for virus subtype (H1N1 and H3N2). The nonparametric Mann-Whitney test was used for comparison between groups. Results show that differentiation in entropy precedes differentiation in GC content for both groups. Considering the HA fragment, both triplet entropy as well as GC concentration show intersection in 2009, year of the recent pandemic. Some conclusions about possible flu evolutionary lines were drawn. © 2013 Elsevier B.V.

Análise ergonômica e intervenções nos postos de trabalho de operadores de caixa de supermercado (checkout)

Pós-graduação em Design - FAAC

Tradução comentada de artigos de Stephen Gray (1966-1736) e reprodução de experimentos históricos com materiais acessíveis: subsídios para o ensino de eletricidade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Programa de gestão única da rede pública de ensino de Mato Grosso: acesso ao sistema único pela via neoliberal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Rede urbana, cidade de porte médio e cidade média: estudos sobre Guarapuava no estado do Paraná

Pós-graduação em Geografia - FCT

Avaliação espaço-temporal da ictiofauna na área de influência do Reservatório de Tucuruí, PA

Pós-graduação em Aquicultura - FCAV

Princípios teóricos de Cutter, Kaiser e Ranganathan como elementos de interlocução na Organização do Conhecimento

The research universe of knowledge organization requires a consistent theoretical conception that promotes an effective application of its tools. In this sense, a dialogical basis is established among the theoretical principles of Cutter’s Subject Cataloguing, Kaiser’s Systematic Indexing and Ranganathan’s Faceted Classification, as a basis for a theoretical timeline of the epistemology of knowledge organization. It is possible to conclude that those three theoretical approaches can be organized in a chronological and conceptual row, showing the growing importance of facets in knowledge organization theory.

Jornalismo no ciberespaço: estudo de caso do portal UOL

The aim of this paper is to analyze the development of the Internet through the shifts that it has brought to the field of journalism and social communication. With the view of doing so, I describe a timeline of the creation and expansion of the network of computers in Brazil and in the world; and then, finally, I give an account of a new paradigm of communication, the alleveryone communication. In the end, it will have a case study of the portal UOL, which will apply all the concepts

As representações de Medeia nas Metamorfoses de Ovídio e na Argonáutica de Apolônio de Rodes

This paper focuses on how the ancient roman poet Ovid’s approach on the mythical character Medea in Metamorphoses Book VII relates to the presence of the character in the Hellenistic greek epic poem Argonautica of Apollonius Rhodius, once the Greek author is known to influence the Roman. Although Ovid’s narrative goes further and focuses on events subsequent to the Argonauts travel, the relationship between the two works allows to address two aspects: the inner monologue and the anxieties of Medea which, by their turn, draw a timeline of the historical influence of Euripedes’ tragedy Medea; going through Apollonius and eventually arriving at Ovid; and the description of Medea’s magical practices and powers, used in Argonautica to protect Jason, which are widely described in Metamorphoses when she rejuvenates Aeson, the hero’s father. It is intended not only to point out aspects of character related to these topics, but primarily to address the mechanisms that can identify the direct influence of Apollonius on Ovid

A fotografia amadora e fotoclubista no Brasil e no México: trajetórias e conexões latino-americanas (1940-1950)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Padronagem visual e cultural japonesa: cerâmica e kimono

Pós-graduação em Artes - IA

A atuação internacional do Brasil para as mudanças climáticas: as COP de 2009 a 2015

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)