Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus

Objective: The objective of this study was to compare the expression of proteins p53, MDM2, and SUMO-1 in oral lichen planus (OLP) lesions, epithelial dysplasia, and squamous cell carcinoma. Materials and Methods: The sample consisted of the following five groups of cheek mucosa lesions: normal mucosa (NM), inflammatory fibrous hyperplasia (IFH), lichen planus, epithelial dysplasia, and squamous cell carcinoma. The tissue samples were stained with hematoxylin-eosin and submitted to immunohistochemistry using anti-p53, anti-MDM2, and anti-SUMO-1 antibodies. Results: The results of this study demonstrated similar expression of p53 and MDM2 between OLP, oral epithelial dysplasia and, to a lesser extent, between OLP and oral squamous cell carcinoma (OSCC). However, for SUMO-1 a similar expression was observed in OLP, NM, and IFH. Conclusions: The results demonstrated overexpression of important proteins (p53 and MDM2) related to regulatory mechanisms of apoptosis in OLP, suggesting that there is a favorable environment for malignant transformation. The expression of SUMO-1 in OLP was similar to NM and IFH, suggesting that alterations of this protein occur at later stages of carcinogenesis, because important overexpression occurred in oral epithelial dysplasia and OSCC. © 2013 John Wiley & Sons A/S.

Avaliação da expressão das proteínas p53, MDM2 e SUMO-1 em líquen plano bucal, displasia epitelial bucal e carcinoma de células escamosas bucal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Expressão dos genes Vip3Aa e Cry1Ia em Escherichia coli efetivos no controle de Spodoptera frugiperda

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Clonagem e expressão do gene da nucleoproteína (np) do vírus da doença de newcastle em Escherichia coli para aplicação no imunodiagnóstico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Produção de antígenos recombinantes do vírus da doença de Newcastle para aplicação no imunodiagnóstico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Construção linguístico-computacional de um ontoglossário inglês-português do domínio léxico-conceitual LOVE LIFE

Pós-graduação em Linguística e Língua Portuguesa - FCLAR

Caracterização funcional da proteína MxA: estudo do seu envolvimento com a mauinaria de SUMOilação

Pós-graduação em Biotecnologia - IQ

Arquivo e literatura: perspectivas de acesso e difusão da memória literária no Brasil

Besides storing, the culture and science institutions in charge of the of Brazilian writers’ personal archives play such an important role on the organization and representation of the country’s literary information. In general, the target public for these collections is composed by researchers from the field of Literature once the documents produced by the writers throughout his/her life and career constitute primary research source for the artistic, historical and literary investigation. However, it is still convenient to stand out those users with no academic instruction, whose interest in such collections is justified by their looking up to the individual. In this sense, literary memory places, such as the Brazilian Literature Archive Museum – AMLB (RJ) -, the Brazilian Literature Academy – ABL – (RJ) and the Brazilian Studies Institute – IEB – (SP) turn out to be responsible for offering access to the literary archives and literary information. Thus, it is necessary to consider that databases demonstrate themselves as utter disseminators of the preservation and diffusion of the literary memory, coming up with several possibilities for cultural and scientific action in Literature. This study focuses on showing the contributions of databases towards the literary archives, the challenges and perspectives observed according to the mentioned institutions’ reality, in whose missions the discourse of the literary memory preservation is inserted.

Caracterização funcional da proteína XAC1201 envolvida na patogenicidade de Xanthomonas citri subsp. citri

Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV

Interação de proteínas Vip3A e Cry1la10 de Bacillus thuringiensis com atividade inseticida a lepidópteros-praga

Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV

Os sentidos da cirurgia estética: utilidade, futilidade, agência e/ou incorporação

This article aims to reflect on the growth of the practice of plastic surgery for cosmetic purposes and its relationship with the contemporary consumer culture. In other words, we discuss how this practice expresses the values and principles for consumer culture and configures itself differently in different contextsin, as the cities of Sao Paulo and London, where he held field work involving the collection of information in press materials, data files, interviews and observation in clinical aes‐ thetic.

Produção da nucleoproteína recombinante do vírus da influenza aviária para aplicação no imunodiagnóstico

Pós-graduação em Microbiologia Agropecuária - FCAV

MxA interacts with and is modified by the SUMOylation machinery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise isotópica do gás carbônico de espumantes comercializados no Brasil

Pós-graduação em Agronomia (Energia na Agricultura) - FCA