Expression of nonclassical molecule human leukocyte antigen-G in oral lesions

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expression of the nonclassical HLA-G and HLA-E molecules in laryngeal lesions as biomarkers of tumor invasiveness

Introduction: HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate and adaptive immune responses, and the expression of these molecules in virus infected cells has been associated with subversion of the immune response. Objective: In this study we performed a cross-sectional study, systematically comparing the expression of HLA-G and HLA-E in benign, premalignant and malignant laryngeal lesions, correlating with demographic and clinical variables and with the presence of high-risk and low-risk HPV types. Materials and methods: Laryngeal lesions were collected from 109 patients and stratified into 27 laryngeal papillomas, 17 dysplasias, 10 in situ laryngeal carcinomas, 27 laryngeal carcinomas without metastases, 28 laryngeal carcinomas with metastasis along with their respective draining cervical lymph nodes, and 10 normal larynx specimens. The expression of HLA-G and HLA-E molecules was determined by immunohistochemistry. HPV DNA detection and typing was performed using generic and specific primers. Results: HLA nonclassical molecules showed a distinct distribution pattern, according to the larynx lesion grade. HLA-G expression increased in benign and premalignant lesions, and gradually decreased in invasive carcinomas and in respective draining cervical lymph nodes. Conversely, HLA-E expression increased as far as lesion grade increased, including increased molecule expression in the draining lymph nodes of malignant lesions. Only 17 (15.6%) patients were HPV DNA positive. Conclusions: Overexpression of HLA-E and underexpression of HLAG appear to be good markers for malignant larynx lesion.

Explanations and Representations of Violence by School-age Brazilian Youths

The violence staged by young people has often been subjected to scientific analysis. The way youths speak, in their role as aggressors or as victims, is examined to determine how they experience violence in a number of different spheres. Repeated group interviews are used to analyze how violence is explained and depicted within the family, at school and in the neighbourhood by two groups of young people (14-17 years old) attending the same school on the outskirts of Rio Claro, Sao Paulo, Brazil. One of the groups involved is identified by the school as violent, and the other, as non-violent. Discourse analysis leads to two conclusions. First, the different contexts of violence infuse a mistrust of institutions, the environment and personal relationships into the subjects' experience, forming a fabric that clouds future prospects. Second, the group of youths identified as violent have a more simplistic, pessimistic view of reality: They see the world in black and white, and they lay no stock in the possibility that violence can be avoided. Consequently, they use violence and understand violence as a defensive strategy that gives one identity. On the other hand, the group identified as nonviolent feels it possible to intervene in situations with nonviolent tools like words. For the young subjects, violence is a context that they assume; it cancels their ability to identify rules and institutions, but it does not generate an effective interaction strategy. Violence causes their social microcontext (in which action prevails over meaning or meaning equals action) to assume overblown dimensions. Any intervention strategy must take into account this indissoluble unity between meaning and action.

Construction of the dispositions of institutional habitus in the academic field

This paper describes the main phases of development of an Institute of Chemistry in relation with national policy from the academic field. Its history begins with a proposal to meet the demand for chemistry teacher education and goes on to become a major center for research, education and extension. Throughout its 50 years of history, the Institution has faced numerous challenges by adopting strategies that have established and revealed its institutional habitus. To this end, we use some of René Kaës’s concepts about the development of groups and institutions, highlighting mainly the origins, expectations and covenants that underpinned its foundation, and the entire process of its expansion and institutionalization. Our main focus, also interpreted based on the theory of Pierre Bourdieu and followers, is the establishment of its institutional habitus, i.e., how it interprets and organizes its institutional teaching, research and extension activities within the context of the academic field. The peculiarity of the process has been the mismatch between internal and external pressures. Even though presenting the results of a case study, in general, our methodology can improve the understanding of institution’s development in relation with educational policy.

Estudos de avaliação quantitativa e qualitativa de linguagens documentárias: uma síntese bibliográfica

Este estudo apresenta uma síntese bibliográfica sobre as metodologias de avaliação que foram propostas por pesquisadores internacionais e nacionais e utilizadas por indexadores de instituições de ensino e/ou pesquisas atuantes em unidades de informação e/ou centros de documentação, bem como aquelas que foram analisadas pelas opiniões dos próprios usuários da informação registrada e disponibilizada em inúmeros sistemas de informações, com enfoques nas abordagens quantitativa, qualitativa e qualitativa/cognitiva, respectivamente.

Atividades psiquiátricas no campo dos transtornos devidos ao uso de substâncias psicoativas

There are a large number of institutions, proposals and publications in the field of disorders resulting from the use of psychoactive substances. There is no corresponding progress in results obtained in clinical treatments. Concepts and appropriate points of view are indispensable. The vision of the world drug addicts is not only determined by the biochemical effects of intoxication, but also by the experience they go through, by their own way of living. By accepting such postulate, we may conceptualize the problem, thus benefiting research studies and more efficient treatments. Preventing intoxication, upon the onset of dependence, depends on educational, social, legal and other measures, which can neither be studied nor practiced by medicine.

Using remote lab networks to provide support to public secondary school education level

The advantages of networking are widely known in many areas (from business to personal ones). One particular area where networks have also proved their benefits is education. Taking the secondary school education level into account, some successful cases can be found in literature. In this paper we describe a particular remote lab network supporting physical experiments accessible to students of institutions geographically separated. The network architecture and application examples of using some of the available remote experiments are illustrated in detail. ©2008 IEEE.

História da Matemática em contextos da Educação Matemática: contribuições do GPHM

In this article we tried to show the paths outlined during the past years by the Research Group on History of Mathematics and/or its relations with Mathematics Education (GPHM) at UNESP in Rio Claro - Brazil, as well as the contributions we believe we have made to Mathematics Education. The group's production has focused on issues that address the history of institutions and characters, linked to the history of disciplines, concepts and learning materials. Also, in broader terms of mathematics education, this article presents results from research that supports the understanding of teachers' conceptions about the use of History of Mathematics in the classroom; material on the history of mathematics accessible to the teacher; the presence of the history of mathematics in textbooks; proposed introductions of real numbers; and the subject of Analysis in teacher education and training.

Monitoramento de hosts em redes tcp/ip sobre base georreferenciada com métricas de qualidade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Os descaminhos da bem-aventurança: um estudo sobre a origem e os desdobramentos da concepção de crise paradigmática de Boaventura de Sousa Santos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O atendimento público e privado concenssionário na educação infantil: um olhar sobre as condições de oferta

Pós-graduação em Educação - IBRC

Educação ambiental e temas controversos: os conflitos socioambientais no contexto de um processo de formação continuada

Pós-graduação em Educação - IBRC

Candido Mota e a política de atendimento a menores delinquentes no Estado de São Paulo, 1894-1909

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O demonio renitente: demonologia e colonização no vice reinado do Peru, séculos XVI e XVII

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Reinações na Jecatatuásia: aspectos estético-sociológicos da arte segundo Monteiro Lobato

Pós-graduação em Letras - FCLAS