Qualidade microbiológica de rações para cães comercializadas no varejo em embalagem fechada e a granel

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Regulamentação Sanitária de Medicamentos

A regulamentação sanitária de medicamentos é uma das oito diretrizes da Política Nacional de Medicamentos. Trata-se da fiscalização e regulamentação de registro de medicamentos e da autorização de funcionamento desde os produtores até o varejo de medicamentos, bem como das restrições àqueles sujeitos a controle especial. A regulamentação sanitária de medicamentos tem como objetivo garantir eficácia, segurança, qualidade e custo aos produtos farmacêuticos. Os estudos clínicos dos medicamentos de Referência, a bioequivalência ou biodisponibilidade relativa e testes de equivalência dos medicamentos similares e genéricos são meios de avaliar a eficácia e a segurança. A qualidade é garantida lote a lote pelas Boas Práticas de Fabricação e Controle dos produtos farmacêuticos e a certificação da empresa pela ANVISA. O custo é avaliado pela câmara técnica de medicamento (CMED), que estabelece os critérios para fixação e ajuste de preços dos produtos farmacêuticos. No pós-registro, a efetividade, segurança e qualidade dos produtos são avaliadas por meio das comprovações exigidas na renovação do registro e, principalmente, pelo programa de farmacovigilância. Palavras-chave: Registro de Produtos. Medicamentos de Referência. Medicamentos Similares. Medicamentos Genéricos. Alteração de Registro de Produtos. ABSTRACT Health Regulations for Drugs The health regulation of drugs is one of eight guidelines issued within the National Drug Policy. It refers to the supervision and regulation of drug registration and the approval of operations, from the manufacturers to the retailers of medicines, as well as the restrictions that apply to drugs under special control. The health regulation of medicines is aimed at controlling the effectiveness, safety, quality and cost of pharmaceutical products. Clinical studies of brand-name (innovator) medicines, bioequivalence or relative bioavailability and the equivalence tests of generic and ‘similar’ brand-name drugs are means used to assess efficacy and safety. Quality is assured on a batch-to-batch basis by compliance with the Good Manufacturing Practices and Control of pharmaceutical products and by the certification of companies offered by ANVISA. The cost of a medicine is assessed by the Technical Chamber of Medicine (CMED), which establishes the criteria for setting and adjusting the prices of pharmaceutical products. After registration, the effectiveness, safety and quality of products are monitored by means of the tests required on renewal of registration and especially by the pharmacovigilance program. Keywords: Product Registration. Original Brand-name Drugs. Similar Drugs. Generic Drugs. Modification of Product Registration.

Transição para um novo centro de distribuição logístico em uma indústria de confecção

In a highly competitive environment for manufacturers and retailers in the garment sector, flexible solutions for warehousing, distribution and exhibition of products directly influence the cost and responsiveness to market demands. This work refers to a Textile/Clothing, which undergoes a process of restructuring and growth, where we evaluated the need for professionalism in all its processes, so that the high demands were met in a sales perennial. Thus, this study aims to identify and analyze possible improvements in the process of transition from a logistics/manufacturing force in a Textile/Clothing in existence since 1998, located in São Paulo, a framework for a new logistics Center Distribution Logistics. The theoretical basis of the research literature addresses as Distribution Center and its basic functions, layout and performance indicators. As result it was mapped the current logistics processes, contributing directly to the development of the layout of the new Distribution Center. Have also been established KPI,s ( Key Performance Indicator) and Logistics Performance Indicators showing the actual process performance, helping professionals in make decisions

Análise do clima organizacional na integração de duas empresas do setor varejista: identificando dificuldades e possibilidades de melhoria

In 2010 two retailers signed an association agreement to gain an advantage in the market, however this association has promoted many changes within the companies. So this study had the objective to analyze the organizational climate, in the integration of companies context, in order to early detect deficiencies that could pose risks to the process of integration. The results collected from the questionnaires revealed the perceptions and expectations of employees regarding the integration of companies and their level of satisfaction with the organization, in addition, the data obtained from interviews allowed us to understand and to find some causes to the level of satisfaction presented by employees. The results made possible to identify strengths as the company‟s image, points of failure in communication and training and dissatisfaction with the workload, then some actions were suggested with the intention to achieve greater engagement and commitment of employees and consequently contribute to the success of the Integration Program. The conclusion of this study is that the changes promoted by the integration of companies impacted in the organizational climate and increased employees dissatisfaction

Mudanças estruturais nas cadeias de valor na indústria do vestuário: um estudo de caso

In the early 1990 Gary Gereffi and Miguel Korzeniewicz published the book Commodity Chains and Global Capitalism. In the two decades prior to the publication, industrialization worldwide, had undergone significant changes, made more segmented and dispersed in certain regions. In the book, the authors produce a new set of categories to analyze the new standards for establishment and operation of global value chains, their organization, the new geography of manufacturing and the role of the countries in this scenario. Today, in the middle of the second decade of this century, world trade has expanded and multiplied continuously throughout this period, encouraged by reducing barriers and national borders promoted by 'peddlers' of this new era. The purpose of this study is to show that retailers are establishing purchasing offices in producing countries - or in nearby regions - to directly hire outsourced production

Validação de protocolo sensorial para avaliação de carne bovina

Beef quality control, particularly its sensory characteristics, is an important factor for producers and retailers in order to satisfy consumer’s choices. Sensory analysis is an important tool to evaluate attributes that cannot be measured by easily available instrumental techniques, as well as texture – tenderness and juiciness – whose human perception is more complete, through trained panels. The aim of this study was evaluate the use of a beef sensory analysis protocol in three different laboratories. Six commercial samples of different brands of aged beef and 14 samples from crossbred animals (Bonsmara × Nelore - 7 and Canchim × Nelore - 7), aged during 14 days were analyzed. The samples were distributed to each participant laboratory, where 7 to 12 panelists were trained. A sheet containing a 9 cm non-structured scale with 14 attributes was used. The attributes were brown colour (CMAR); aponevrosis (PNAP); hydration degree (GH); characteristic beef aroma (SCCB); salty taste (SS); liver flavour (SF); fat flavour (SG); metallic flavour (SM); tenderness (MZ); juiciness (SL); fibrosity (FBS) and liver texture (SF). Obtained data was analyzed using analysis of variance and principal component analysis (PCA). The results showed that there was no interaction between samples and laboratories, indicating that all of them responded in a similar manner in relation to the samples, except PNAP attribute, which was expected as meat is very non-uniform normally. Samples were well differentiated in all laboratories as it could be observed in PCA graphs. With proper training it is possible to use a standard protocol for beef sensory analysis.