3 resultados para radicales

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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The curricula study allows the verification of trends, concepts and the identification of teaching practices, enabling the planning and implementation of changes when necessary. The material presented here is part of the results obtained in a postgraduate research that deals with the training of psychologists to work with people with disabilities, which appealed to the document analysis. To accomplish this task it was used a methodological procedure named searching through radical, which allowed greater agility to the search, enabling the quick identification of the courses containing topics of interest for research, facilitating their selection to study. The use of document analysis as a methodology allowed both the collection and organization of information that were diffused, providing them new configuration as source of information, as the processing and interpretation of the raw data, giving them direction and adding them value. In 36 courses, 35 had at least one subject related to persons with disabilities, and the sum of these resulted in 85 subjects for analysis. The interpretation of data obtained through reading the menus brought information about prevalent intentions on the menus of the subjects, to research in the area, teaching procedures, techniques and possibilities of action and insertion of psychologists in different contexts in which they can deal with disability. In a positive perspective, the results showed that there seems to be a tendency to enhance the interface of psychology with other knowledge areas to understand the issues related to disability.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Introduction: skeletal muscles are dynamic tissue that can change their phenotypic characteristics providing a better functional adaptation to different stimuli. L-thyroxine is a hormone produced by the thyroid gland and has been used as an experimental model for stimulation of oxidative stress in skeletal muscle. Coenzyme Q10 (CoQ10) is a fat-soluble provitamin endogenously synthesized and found naturally in foods such red meat, fish, cereals, broccoli and spinach. It has antioxidant properties and potential in the treatment of degenerative and neuromuscular diseases. Objective: to evaluate the protective effect of CoQ10 in the soleus muscle of rats against the oxidative damage caused by L-thyroxine. Methods: the rats were divided in four groups of six animals each: Group 1 (control); Group 2 (coenzyme Q10); Group 3 (L-thyroxine), and Group 4 coenzyme Q10 and L-thyroxine). After euthanasia, blood was collected and serum activity of the enzymes creatine kinase (CK) and aspartate aminotransferase (AST) was analyzed. In the soleus muscle homogenates the factors related to oxidative stress were assessed. Results: CoQ10 protected the soleus muscle against the damage caused by L-thyroxine and favored the maintenance of the antioxidant enzymes glutathione reductase and glutathione peroxidase, the concentration of decreased and oxidized glutathione, and prevented lipid peroxidation. Conclusion: the results indicate that CoQ10 protects rat soleus muscle from oxidative damage caused by L-thyroxine.