Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports

Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition characterized by the presence of exposed bone in the maxillofacial region. Its pathogenesis is still undetermined, but may be associated with risk factors such as rheumatoid arthritis (RA). The aim of this paper is to report two unpublished cases of BRONJ in patients with RA and to conduct a literature review of similar clinical cases with a view to describe the main issues concerning these patients, including demographic characteristics and therapeutic approaches applied.Methods: Two case reports of BRONJ involving RA patients were discussedResults: Both patients were aging female taking alendronate for more than 3 years. Lesions were detected in stage II in posterior mandible with no clear trigger agent. The treatment applied consisted of antibiotics, oral rinses with chlorhexidine, drug discontinuation and surgical procedures. Complete healing of the lesions was achieved.Conclusions: This paper brings to light the necessity for rheumatologists to be aware of the potential risk to their patients of developing BRONJ and to work together with dentists for the prevention and early detection of the lesions. Although some features seem to link RA with oral BRONJ and act as synergistic effects, more studies should be developed to support the scientific bases for this hypothesis.

Reference Gene Selection for Gene Expression Analysis of Oocytes Collected from Dairy Cattle and Buffaloes during Winter and Summer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cytoskeletal organization of bee ovarian follicles during oogenesis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Comment on Time-reversal symmetry-breaking superconductivity

It is pointed out that erroneous Bardeen-Cooper-Schrieffer model equations have been used by Haranath Ghosh in his recent treatment of time-reversal symmetry-breaking superconductivity. Consequently, his numerical results are misleading, and his conclusions are not to the point.

Influenza among the elderly in the Americas: A consensus statement

Influenza exacts a heavy burden on the elderly, a segment of the population that is estimated to experience rapid growth in the near future. In the past decade most developed and several developing countries have recommended influenza vaccination for those > 65 years of age. The World Health Organization (WHO) set a goal of 75% influenza vaccination coverage among the elderly by 2010, but it was not achieved. In 2011, the Technical Advisory Group at the Pan American Health Organization, Regional Office of WHO for the Americas, reiterated the influenza vaccine recommendation for older adults. Relatively little information has been compiled on the immunological aspect of aging or on reducing its impact, information particularly relevant for clinicians and gerontologist with firsthand experience confronting its effects. To fill this data gap, in 2012 the Americas Health Foundation (Washington, D.C., United States) and the nonprofit, Fighting Infectious Diseases in Emerging Countries (Miami, Florida, United States), convened a panel of Latin American clinicians and gerontologists with expertise in influenza to discuss key issues and develop a consensus statement. The major recommendations were to improve influenza surveillance throughout Latin America so that its impact can be quantified; and to conduct laboratory confirmation of influenza for all patients who have flu-like symptoms and are frail, immunosuppressed, have comorbidities, are respiratory compromised, or have been admitted to a hospital. The panel also noted that: since evidence for antivirals in the elderly is unclear, their use should be handled on a case-by-case basis; despite decreased immunological response, influenza vaccination in older adults is still crucial; indirect immunization strategies should be encouraged; and traditional infection control measures are essential in long-term care facilities.

Da responsabilidade do Estado quanto ao erro judiciário na sentença penal absolutória

Pós-graduação em Direito - FCHS

A qualidade dos serviços educacionais e a proteção do código de defesa do consumidor

Pós-graduação em Direito - FCHS

Educação prisional no estado de São Paulo: passado, presente e futuro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação dos registros de profilaxia anti-rábica humana pós-exposição no Município de Jaboticabal, são Paulo, no período de 2000 a 2006

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Componentes da síndrome metabólica preditores da capacidade aeróbica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A interlocução do Serviço Social com os movimentos sociais no Brasil: uma análise a partir da produção teórica com enfoque no trabalho profissional

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Responsabilidade do estado no combate à corrupção

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Variabilidade genética em progênies de meios-irmãos de eucalyptus dunnii maiden para resistência a ferrugem (Puccinia psidii winter) em diferentes ambientes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Enxerto alógeno de ligamento patelar conservado em glicerina e fixado com parafusos de interferência como substituto do ligamento cruzado cranial em cães

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Microbiota intestinal em pacientes com infecções bacterianas do trato respiratório tratados com amoxicilina

Pós-graduação em Doenças Tropicais - FMB