Geographic variations in the composition of myotoxins from Bothrops neuwiedi snake venoms: biochemical characterization and biological activity

(1) Venom pools from Bothrops neuwiedi (Bn) and from two subspecies, namely Bothrops neuwiedi pauloensis (Bnp) and Bothrops neuwiedi urutu (Bnu), collected in the States of São Paulo (SP) and Minas Gerais (MG), Brazil, were electrophoretically examined. Basic toxins with different isoelectric points were identified in the venom collected in São Paulo (BnSP). These toxins were absent in the corresponding pools from Minas Gerais (BnMG, BnpMG and BnuMG). (2) BnSP, but not BnMG, BnpMG or BnuMG, showed two myotoxins (pI congruent to 8.6 and 8.8, respectively) which were isolated by ion-exchange chromatography on CM-Sepharose. (3) From BnMG, three myotoxic isoforms (pI congruent to 8.2 and M-r = 13600) were isolated by chromatography on CM-Sepharose followed by reversed-phase high-performance liquid chromatography. (4) the chemical and biological characterization of these toxins showed a high similarity with the Lys-49 myotoxins from other bothropic venoms. (5) Doses up to 5 LD50 (i.p.) of p-bromophenacyl bromide alkylated BnSP-7 caused a total loss of lethality in 18-22-g mice, thus indicating that the LD50 was increased by greater than 5-fold. At this dose myotoxicity was also not detectable, but the edematogenic activity on the rat paw apparently did not change. (C) 1998 Elsevier B.V. All rights reserved.

Charges and fluxes in Maxwell theory on compact manifolds with boundary

We investigate the charges and fluxes that can occur in higher-order Abelian gauge theories defined on compact space-time manifolds with boundary. The boundary is necessary to supply a destination to the electric lines of force emanating from brane sources, thus allowing non-zero net electric charges, but it also introduces new types of electric and magnetic flux. The resulting structure of currents, charges, and fluxes is studied and expressed in the language of relative homology and de Rham cohomology and the corresponding abelian groups. These can be organised in terms of a pair of exact sequences related by the Poincare-Lefschetz isomorphism and by a weaker flip symmetry exchanging the ends of the sequences. It is shown how all this structure is brought into play by the imposition of the appropriately generalised Maxwell's equations. The requirement that these equations be integrable restricts the world-volume of a permitted brane (assumed closed) to be homologous to a cycle on the boundary of space-time. All electric charges and magnetic fluxes are quantised and satisfy the Dirac quantisation condition. But through some boundary cycles there may be unquantised electric fluxes associated with quantised magnetic fluxes and so dyonic in nature.

Conformal structures and twistors in the paravector model of spacetime

Some properties of the Clifford algebras Cl-3,Cl-0, Cl-1,Cl-3, Cl-4,Cl-1 similar or equal to C circle times Cl-1,Cl-3 and Cl-2,Cl-4 are presented, and three isomorphisms between the Dirac-Clifford algebra C circle times Cl-1,Cl-3 and Cl-4,Cl-1 are exhibited, in order to construct conformal maps and twistors, using the paravector model of spacetime. The isomorphism between the twistor space inner product isometry group SU( 2,2) and the group $pin(+)(2,4) is also investigated, in the light of a suitable isomorphism between C circle times Cl-1,Cl-3 and Cl-4,Cl-1. After reviewing the conformal spacetime structure, conformal maps are described in Minkowski spacetime as the twisted adjoint representation of $ pin(+)(2,4), acting on paravectors. Twistors are then presented via the paravector model of Clifford algebras and related to conformal maps in the Clifford algebra over the Lorentzian R-4,(1) spacetime.We construct twistors in Minkowski spacetime as algebraic spinors associated with the Dirac-Clifford algebra C circle times Cl-1,Cl-3 using one lower spacetime dimension than standard Clifford algebra formulations, since for this purpose, the Clifford algebra over R-4,R-1 is also used to describe conformal maps, instead of R-2,(4). Our formalism sheds some new light on the use of the paravector model and generalizations.

A new proposal for the picture changing operators in the minimal pure spinor formalism

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

STRONG COUPLING LIMITS and QUANTUM ISOMORPHISMS of THE GAUGED THIRRING MODEL

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Immersions in the metastable dimension range via the normal bordism approach

Let f : M --> N be a continuous map between two closed n-manifolds such that f(*): H-*(M, Z(2)) --> H-* (N, Z(2)) is an isomorphism. Suppose that M immerses in Rn+k for 5 less than or equal to n < 2k. Then N also immerses in Rn+k. We use techniques of normal bordism theory to prove this result and we show that for a large family of spaces we can replace the homolog condition by the corresponding one in homotopy. (C) 2001 Elsevier B.V. B.V. All rights reserved.

Remarks on immersions in the metastable dimension range

In this work we present a generalization of an exact sequence of normal bordism groups given in a paper by H. A. Salomonsen (Math. Scand. 32 (1973), 87-111). This is applied to prove that if h : M-n --> Xn+k, 5 less than or equal to n < 2k, is a continuous map between two manifolds and g : M-n --> BO is the classifying map of the stable normal bundle of h such that (h, g)(*) : H-i (M, Z(2)) --> H-i (X x BO, Z(2)) is an isomorphism for i < n - k and an epimorphism for i = n - k, then h bordant to an immersion implies that h is homotopic to an immersion. The second remark complements the result of C. Biasi, D. L. Goncalves and A. K. M. Libardi (Topology Applic. 116 (2001), 293-303) and it concerns conditions for which there exist immersions in the metastable dimension range. Some applications and examples for the main results are also given.

Some remarks on the conformal group

It is shown that the local isomorphism between the conformal group of Minkowski spacetime and the group SO(4,2) makes sense only if one eliminates from SO(4,2) one of the Sitter boosts contained in it. © 1992.

Vozes das formas na poesia concreta do Grupo Noigandres

Pós-graduação em Artes - IA

Formação de professores e avaliação formativa: análise de um projeto de interação universidade-escola

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Some mathematical aspects and scattering amplitudes in the pure spinor formalism

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Grupos wallpaper e sua relação com cohomologia de grupos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O problema do Paralelismo Psicofisiológico segundo a Epistemologia Genética

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O papel dos stakeholders na adoção de práticas de green supply chain management: estudo de caso em uma cadeia de suprimentos do setor de baterias automotivas

Pós-graduação em Engenharia de Produção - FEB

Sobre certas teorias de cohomologia de grupos e aplicações

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)