Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats

We investigated the behavioral and molecular interactions between cocaine and nicotine, through evaluating locomotor activity, nicotine intravenous self-administration and gene expression. Locomotor sensitization was induced in male Wistar rats by repeated cocaine (20 mg/kg; i.p.) or saline injections once a day over 7 days. Three days after the last injection, rats were challenged with either saline or cocaine (15 mg/kg; i.p.) and the locomotor activity was measured. The very next day animals received either saline or nicotine (0.4 mg/kg; s.c.) and the locomotor cross-sensitization was tested. Animals were then prepared with intrajugular catheters for nicotine self-administration. Nicotine self-administration patterns were evaluated using fixed or progressive ratio schedules of reinforcement and a 24-h unlimited access binge. Immediately after the binge sessions animals were decapitated, the brains were removed and the nucleus accumbens was dissected. The dynorphin (DYN), μ-opioid receptor (mu opioid), neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), tropomyosin-related tyrosine kinase B receptor (TrkB) and corticotropin- releasing factor receptor type 1 (CRF-R1) gene expression were measured by the reverse transcription-polymerase chain reaction (RT-PCR). Pretreatment with cocaine caused sensitization of cocaine motor response and locomotor cross-sensitization with nicotine. In the self-administration experiments repeated cocaine administration caused an increase in the nicotine break point and nicotine intake during a 24 h binge session. © 2013 Elsevier Inc.

Information Search Behavior: Proposal of Study with Investors in the Stock Market

With the aim of analyzing the information search behavior of investors working in the stock market, this research sought to raise the aspects related to this behavior with focus on the cognitive and causal aspects which pervade the need for information of these investors. For that, the general pattern of informational behavior proposed by Wilson [10], and also the analysis of a report from an investor of the stock market area were used as basis for the analysis and reflection. The report of only one investor was used as basis for investigation, turning it impossible to extrapolate such result to a greater universe. The objective of this research was to investigate the need for information, the context and the intervenient variables which might interfere or not in the information search behavior of investors, in an attempt to get a deeper comprehension about the subject, as well as to propose the continuity of studies with basis on this study proposal.

O comportamento informacional de advogados: um estudo com profissionais que atuam na cidade de Marília e região

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comportamento de busca da informação ambiental por pesquisadores da área de meio ambiente

Pós-graduação em Ciência da Informação - FFC

O uso da informação no âmbito acadêmico: o comportamento informacional de pós-graduandos da área de Educação

This study reports part of a broader research about information behavior of graduate students in Education. The research´s participants were nine masters and doctoral students from a graduate program in Education at a public university. The focus group technique was used to collect the data. The focus group sessions were observed and recorded. The recorded data were transcribed, categorized and then analyzed using the technique of content analysis. The main aspects achieved were: i) Identification’s forms of information resources for research; ii) Internet as source of information; iii) Academic Library’s services and resources use; iv) Training to use of electronic data base; v) Difficulties to perform the search; vi) Advisor’s influence on research development; and vii) Environmental factors that affect information seeking behavior. The main results reveal that the identification of information sources occurs, mainly, through references quoted on studies of the researched area; as well as the advisors’ influence in the information seeking behavior of the participants. The results, also, disclose some environmental aspects, as example, lack of time to search and discomfort caused by the libraries’ environment that influenced negatively the information behavior of the studied group.

Comportamento informacional de pós-graduandos de educação: estudo sobre as variáveis intervenientes

Pós-graduação em Ciência da Informação - FFC

Inteligência competitiva organizacional: um modelo apoiado nos comportamentos de busca, compartilhamento e uso de informação e de TIC

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Tecnologias de Informação e Comunicação no cotidiano dos adolescentes: enfoque no comportamento e na competências informacionais da geração Google

Introduction: Individuals born from the 1990’s to accompany technological change course and learn how to use the technological resources that have access before they even learn to read or write. In this sense, the literature considers the digital natives or even 'Google generation'. However, it has been questioned their skills to identify information needs and seeking and use of information in the most varied environments digital information available on the Web. Objectives: To characterize the behavior of information seeking in everyday life of a group of teenage students from a private school in Marilia, Sao Paulo. Methodology: A qualitative study with 30 adolescent students of a private school in Marilia, Sao Paulo. Data collection was accomplished at first by means of a questionnaire, based on the research of Hughes-Hussell and August (2007), containing questions about age, gender, hobbies and everyday tasks, and issues the use of computers and the internet, which allowed determination of the social, economic and cultural rights of respondents. Results: have focused on the use of Information and Communication Technologies (ICT) to search access and use information. It was suggested that the "Brotherhood of Informatics', an incentive for students to (re) learn the tools of digital communication and make appropriate use of the resources, products and services on the web to search and effective use of information compatible with their needs and that is tied to the ethical and responsible use of technology environments. Conclusions: The results arising from this study will continue through the continuation of the Confraternity of Computing, which became a "thermometer" on the use of digital information environments and the attitude of the students in front of Information and Communication Technologies in the College “Cristo Rei”.

Stress-induced reinstatement of amphetamine-conditioned place preference and changes in tyrosine hydroxylase in the nucleus accumbens in adolescent rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors

An involvement of the transient receptor potential vanilloid (TRPV) 1 channel in the regulation of body temperature (T b) has not been established decisively. To provide decisive evidence for such an involvement and determine its mechanisms were the aims of the present study. We synthesized a new TRPV1 antagonist, AMG0347 [(E)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1- yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide], and characterized it in vitro. We then found that this drug is the most potent TRPV1 antagonist known to increase T b of rats and mice and showed (by using knock-out mice) that the entire hyperthermic effect of AMG0347 is TRPV1 dependent. AMG0347-induced hyperthermia was brought about by one or both of the two major autonomic cold-defense effector mechanisms (tail-skin vasoconstriction and/or thermogenesis), but it did not involve warmth-seeking behavior. The magnitude of the hyperthermic response depended on neither T b nor tail-skin temperature at the time of AMG0347 administration, thus indicating that AMG0347-induced hyperthermia results from blockade of tonic TRPV1 activation by nonthermal factors. AMG0347 was no more effective in causing hyperthermia when administered into the brain (intracerebroventricularly) or spinal cord (intrathecally) than when given systemically (intravenously), which indicates a peripheral site of action. We then established that localized intra-abdominal desensitization of TRPV1 channels with intraperitoneal resiniferatoxin blocks the T b response to systemic AMG0347; the extent of desensitization was determined by using a comprehensive battery of functional tests. We conclude that tonic activation of TRPV1 channels in the abdominal viscera by yet unidentified nonthermal factors inhibits skin vasoconstriction and thermogenesis, thus having a suppressive effect on T b. Copyright © 2007 Society for Neuroscience.

Vasectomia no sistema público de saúde: Características dos candidatos e variáveis associadas

Objective: This study aimed to characterize candidates undergo vasectomy in the public health system, Araçatuba- SP and to study related variables. Methods: We surveyed 300 medical patients and vasectomized contacted by telephone to assess several characteristics. The variables analyzed for the study were age, marital status, education, religion, monthly family income and per capita, number of living children, reason for seeking treatment method, contraceptive use, marital relationship quality, decision time (date of intent to perform the procedure) and not because of the procedure. Data were pooled for the analysis of results. Results: The age of the candidates ranged from 23 to 65 years (mean 36.86 years) and average 2.56 living sons. The average monthly family income was R$ 1.079,15, with average per capita income of R$ 249,07. The couple's contraception before the procedure was on account of the woman who used oral anti-conception (84%). The complication rate with the method was around 6.04%, the biggest complication was dehiscence (77.7% of cases of complications), these being mainly during the first 100 cases. Conclusion: Vasectomy is a very effective contraceptive method, with low complication rate and low cost, should be encouraged by the public health system as a means of family planning policy.

A comunicação interna em departamentos jornalísticos: um estudo em emissoras de redes de televisão sob o enfoque da gestão da informação

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Modelos de comportamento de busca de informação: contribuições para a organização da informação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)