Sistema inteligente híbrido intercomunicativo para detecção de perdas comerciais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise filogenética entre Citrus spp. e Guignardia spp

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Clíticos pronominais no português de São Paulo: 1880 a 1920: uma análise sócio-histórico-linguística

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Hemera: sistematizar textualizações, possibilitar narrativas

Pós-graduação em Educação para a Ciência - FC

Análise comparativa de redes interfirmas de instituições de ensino superior

Organizations have been facing several challenges to survive in a world in constant transformation. In light of that, new management models need to be incorporated to the organizational dynamics in order to achieve competitive advantages. The inter-firm networks establish a particular form means of cooperation as a fundamental element, as there can be ties of diverse nature to justify the relationships. These are interorganizations or inter-firms, formed by people who maintain the relationships to improve the overall performance of the network and of the participants. Thus, the Education Institutions, considered as organizations, which have the objective to disseminate knowledge and form professionals who contribute to the growth of a nation, also make use of this type of arrangement. Considering the raised questions, this article aims to demonstrate the applicability of a business network mapping technique at Higher Education Institutions. It also presents the possibility to perform the comparative analysis of the intensity of the relationship observed in a private and in a public institution, in the State of São Paulo. By applying the comparative analysis, this study also presents the relationship among the people involved at strategic and tactical levels of each institution, taking into account each one s peculiarities.

Exploring the multifactorial nature of autism through computational systems biology: Calcium and the Rho GTPase RAC1 under the spotlight

Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication accompanied with repetitive behavioral patterns and unusual stereotyped interests. Autism is considered a highly heterogeneous disorder with diverse putative causes and associated factors giving rise to variable ranges of symptomatology. Incidence seems to be increasing with time, while the underlying pathophysiological mechanisms remain virtually uncharacterized (or unknown). By systematic review of the literature and a systems biology approach, our aims were to examine the multifactorial nature of autism with its broad range of severity, to ascertain the predominant biological processes, cellular components, and molecular functions integral to the disorder, and finally, to elucidate the most central contributions (genetic and/or environmental) in silico. With this goal, we developed an integrative network model for gene-environment interactions (GENVI model) where calcium (Ca2+) was shown to be its most relevant node. Moreover, considering the present data from our systems biology approach together with the results from the differential gene expression analysis of cerebellar samples from autistic patients, we believe that RAC1, in particular, and the RHO family of GTPases, in general, could play a critical role in the neuropathological events associated with autism. © 2013 Springer Science+Business Media New York.