The two-loop massless (lambda/4!)phi(4) model in nontranslational invariant domain

We study the (lambda/4!)phi(4) massless scalar field theory in a four-dimensional Euclidean space, where all but one of the coordinates are unbounded. We are considering Dirichlet boundary conditions in two hyperplanes, breaking the translation invariance of the system. We show how to implement the perturbative renormalization up to two-loop level of the theory. First, analyzing the full two and four-point functions at the one-loop level, we show that the bulk counterterms are sufficient to render the theory finite. Meanwhile, at the two-loop level, we must also introduce surface counterterms in the bare Lagrangian in order to make finite the full two and also four-point Schwinger functions. (c) 2006 American Institute of Physics.

Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

eIF5A has a function in the elongation step of translation in yeast

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis

Eukaryotic translation initiation factor 5A (eIF5A) is a protein that is highly conserved and essential for cell viability. This factor is the only protein known to contain the unique and essential amino acid residue hypusine. This work focused on the structural and functional characterization of Saccharomyces cerevisiae eIF5A. The tertiary structure of yeast eIF5A was modeled based on the structure of its Leishmania mexicana homologue and this model was used to predict the structural localization of new site-directed and randomly generated mutations. Most of the 40 new mutants exhibited phenotypes that resulted from eIF-5A protein-folding defects. Our data provided evidence that the C-terminal alpha-helix present in yeast eIF5A is an essential structural element, whereas the eIF5A N-terminal 10 amino acid extension not present in archaeal eIF5A homologs, is not. Moreover, the mutants containing substitutions at or in the vicinity of the hypusine modification site displayed nonviable or temperature-sensitive phenotypes and were defective in hypusine modification. Interestingly, two of the temperature-sensitive strains produced stable mutant eIF5A proteins - eIF5A(K56A) and eIF5A(Q22H,L93F)- and showed defects in protein synthesis at the restrictive temperature. Our data revealed important structural features of eIF5A that are required for its vital role in cell viability and underscored an essential function of eIF5A in the translation step of gene expression.

Is there a role for eIF5A in translation?

The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functional characterization of eIF5A. Although this protein was originally identified as a translation initiation factor, subsequent studies did not support a role for eIF5A in general translation initiation. eIF5A has also been implicated in nuclear export of HIV-1 Rev and mRNA decay, but these findings are controversial in the literature and may reflect secondary effects of eIF-5A function. Next, the involvement of eIF5A and hypusination in the control of the cell cycle and proliferation in various organisms is reviewed. Finally, recent evidence in favor of reconsidering the role of eIF5A as a translation factor is discussed. Future studies may reveal the specific mechanism by which eIF5A affects protein synthesis.

eIF5A binds to translational machinery components and affects translation in yeast

The putative translation factor eIF5A is essential for cell viability and is highly conserved from archebacteria to mammals. Although this protein was originally identified as a translation initiation factor, subsequent experiments did not support a role for eIF5A in general translation. In this work, we demonstrate that eIF-5A interacts with structural components of the 80S ribosome, as well as with the translation elongation factor 2 (eEF2). Moreover, eIF5A is further shown to cofractionate with monosomes in a translation-dependent manner. Finally, eIF5A mutants show altered polysome profiles and are sensitive to translation inhibitors. Our results re-establish a function for eIF5A in translation and suggest a role for this factor in translation elongation instead of translation initiation. (c) 2006 Elsevier B.V. All rights reserved.

Remarks on Duffin-Kemmer-Petiau theory and gauge invariance

Two problems relative to the electromagnetic coupling of Duffin-Kemmer-Petiau (DKP) theory are discussed: the presence of an anomalous term in the Hamiltonian form of the theory and the apparent difference between the interaction terms in DKP and Klein-Gordon (KG) Lagrangians. For this, we first discuss the behavior of DKP field and its physical components under gauge transformations. From this analysis, we can show that these problems simply do not exist if one correctly analyses the physical components of DKP field. (C) 2000 Elsevier B.V. B.V. All rights reserved.

One loop conformal invariance of the superstring in an AdS(5) x S-5 background

It is proven that the pure spinor superstring in an AdS(5) x S-5 background remains conformally invariant at one loop level in the sigma model perturbation theory.

Gauge invariance, color-octet vector resonances and double technieta production at the Tevatron

We show that the usual vector meson dominance method does not apply directly to the mixing of a color-octet vector boson (color-octet technirho) with the gluon because of gauge invariance. We propose a gauge invariant method where one works in a physical basis with mass eigenstate fields, As a result, we show that the physical technirho does not couple to two gluons, contrary to the general belief, Consequences for the production of a pair of color-octet, isosinglet technipions (technietas) at Fermilab is analyzed by means of a simulation of the signal and background, including kinematical cuts. We find that the signal is too small to be observed. (C) 2001 Published by Elsevier B.V. B.V.

Lorentz invariance of the pure spinor BRST cohomology for the superstring

In a previous Letter. The BRST cohomology in the pure spinor formalism of the superstring was shown to coincide with the light-cone Green-Schwarz spectrum by using an SO(8) parameterization of the pure spinor. In this Letter, the SO(9, 1) Lorentz generators are explicitly constructed using this SO(8) parameterization, proving the Lorentz invariance of the pure spinor BRST cohomology. (C) 2001 Published by Elsevier B.V. B.V.

Renormalization group invariance of quantum mechanics

We propose a framework to renormalize the nonrelativistic quantum mechanics with arbitrary singular interactions. The scattering equation is written to have one or more subtraction in the kernel at a given energy scale. The scattering amplitude is the solution of a nth order derivative equation in respect to the renormalization scale, which is the nonrelativistic counterpart of the Callan-Symanzik formalism, Scaled running potentials for the subtracted equations keep the physics invariant fur a sliding subtraction point. An example of a singular potential, that requires more than one subtraction to renormalize the theory is shown. (C) 2000 Published by Elsevier B.V. B.V. All rights reserved.

Conformal invariance of massless Duffin-Kemmer-Petiau theory in Riemannian spacetimes

We investigate the conformal invariance of massless Duffin-Kemmer-Petiau theory coupled to Riemannian spacetimes. We show that, as usual, in the minimal coupling procedure only the spin I sector of the theory - which corresponds to the electromagnetic field - is conformally invariant. We also show that the conformal invariance of the spin 0 sector can be naturally achieved by introducing a compensating term in the Lagrangian. Such a procedure - besides not modifying the spin I sector - leads to the well-known conformal coupling between the scalar curvature and the massless Klein-Gordon-Fock field. Going beyond the Riemannian spacetimes, we briefly discuss the effects of a nonvanishing torsion in the scalar case.

Weak-field approximation of effective gravitational theory with local Galilean invariance

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Charged three-body system with arbitrary masses near conformal invariance

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Statistical properties of a dissipative kicked system: Critical exponents and scaling invariance

A new universal empirical function that depends on a single critical exponent (acceleration exponent) is proposed to describe the scaling behavior in a dissipative kicked rotator. The scaling formalism is used to describe two regimes of dissipation: (i) strong dissipation and (ii) weak dissipation. For case (i) the model exhibits a route to chaos known as period doubling and the Feigenbaum constant along the bifurcations is obtained. When weak dissipation is considered the average action as well as its standard deviation are described using scaling arguments with critical exponents. The universal empirical function describes remarkably well a phase transition from limited to unlimited growth of the average action. (C) 2012 Elsevier B.V. All rights reserved.