The surprising evolutionary history of South American deer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pb-210-derived chronology in sediment cores evidencing the anthropogenic occupation history at Corumbata River basin, Brazil

Activity profiles of excess Pb-210 combined with chemical data determined in two sediment cores from Corumbatai River basin, São Paulo State, Brazil, provided new insights into the reconstruction of historical inputs of anthropogenic constituents, contributing to improving management strategies of the hydrological resources in the basin since most of the municipalities extensively utilize the waters of Corumbatai River and tributaries for drinking purposes, among other uses. Excellent significant relationships between loss on ignition (LOI) and organic matter were found for sediments of both analyzed profiles. Silica was found to be inversely related to organic matter at both analyzed profiles: its decrease accompanied an increase in the specific surface of the sediments. This relationship was confirmed by a great number of inverse significant correlations among silica and oxides Na2O, K2O, CaO, MgO, Al2O3, P2O5, Fe2O3, MnO, and TiO2. It was possible to identify the role of organic matter on adsorption of several oxides/elements in the core sediments profiles. Apparent sediment mass accumulation rates corresponding to 224 and 802 mg cm(-2) year(-1) were obtained, and are compatible with field evidence, indicating a higher value associated with sand mining activities interfering with the natural/normal sedimentation process, due to modifications of the channel drainage.

Transmissable Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage

Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of exposure to ultraviolet light. CTVT is remarkably stable and lacks subclonal heterogeneity despite thousands of rearrangements, copy-number changes, and retrotransposon insertions. More than 10,000 genes carry nonsynonymous variants, and 646 genes have been lost. CTVT first arose in a dog with low genomic heterozygosity that may have lived about 11,000 years ago. The cancer spawned by this individual dispersed across continents about 500 years ago. Our results provide a genetic identikit of an ancient dog and demonstrate the robustness of mammalian somatic cells to survive for millennia despite a massive mutation burden.

Foucault's heraclitism and the concept of history

Deleuze states that Foucault would have created a new relationship between men and history, a relationship other than that established by the philosophers of history. In order to specify the steps Foucault took to accomplish this invention, I shall support, according to Deleuze, Foucault s Heraclitism as the basis for a genuine Foucaultian concept of history. After outlining the risks taken by Foucault s concept of history, I observe this concept at work through the three periods that perform his thought: Archeology, Genealogy and Aesthetics of Existence. The main characters that embody his concept of history through these periods are: a) the discontinuous profile of history; b) the denaturalization of would-be unhistorical objects; c) the historical dimension of body; d) the eddies of subjectivation in history. We shall focus our inspection on the turn made along Foucault s work when he takes into a new account the theme of subjectivity, mostly in the last two volumes of the History of Sexuality. Thus, our attention turns to the subjectivity defined as a process, in order to investigate individual identity as the result of history.

Venomics of the Australian eastern brown snake (Pseudonaja textilis): detection of new venom proteins and splicing variants

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)