Expression of nonclassical molecule human leukocyte antigen-G in oral lesions

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expression of the nonclassical HLA-G and HLA-E molecules in laryngeal lesions as biomarkers of tumor invasiveness

Introduction: HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate and adaptive immune responses, and the expression of these molecules in virus infected cells has been associated with subversion of the immune response. Objective: In this study we performed a cross-sectional study, systematically comparing the expression of HLA-G and HLA-E in benign, premalignant and malignant laryngeal lesions, correlating with demographic and clinical variables and with the presence of high-risk and low-risk HPV types. Materials and methods: Laryngeal lesions were collected from 109 patients and stratified into 27 laryngeal papillomas, 17 dysplasias, 10 in situ laryngeal carcinomas, 27 laryngeal carcinomas without metastases, 28 laryngeal carcinomas with metastasis along with their respective draining cervical lymph nodes, and 10 normal larynx specimens. The expression of HLA-G and HLA-E molecules was determined by immunohistochemistry. HPV DNA detection and typing was performed using generic and specific primers. Results: HLA nonclassical molecules showed a distinct distribution pattern, according to the larynx lesion grade. HLA-G expression increased in benign and premalignant lesions, and gradually decreased in invasive carcinomas and in respective draining cervical lymph nodes. Conversely, HLA-E expression increased as far as lesion grade increased, including increased molecule expression in the draining lymph nodes of malignant lesions. Only 17 (15.6%) patients were HPV DNA positive. Conclusions: Overexpression of HLA-E and underexpression of HLAG appear to be good markers for malignant larynx lesion.

A metaficção e as entrelinhas em O doente Molière (2000), de Rubem Fonseca

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Reinações na Jecatatuásia: aspectos estético-sociológicos da arte segundo Monteiro Lobato

Pós-graduação em Letras - FCLAS

Confinamento e vastidão: a representação feminina e a subversão em The magic toyshop

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Balada da praia dos cães: o desafiante romance policial de Cardoso Pires

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

De corixos e de veredas: a alegada similitude entre as poéticas de Manoel de Barros e de Guimarães Rosa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A Estética do Silêncio no Livro do Desassossego: um estudo da escritura em Fernando Pessoa

Pós-graduação em Letras - IBILCE

Homo Risibilis: ensaio sobre o processo de construção do humor nas obras infantis de Monteiro Lobato

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Regimes Militares e a Segurança Nacional no Cone Sul

The implantation of military regimes in South America, from the mid-1960s, happened in the context of the Cold War. As a result, both the occurrence of military coups and the plans and actions for the national defense of the Southern Cone States occurred following the logic of that period and the concept of hemispheric defense preached by the United States, with priority in combating the so-called internal subversion. Thus, the need to combat the “internal enemy” has led these countries to participate in hemispheric mechanisms or create his own arrangements for coordination. The article starts from the conflict hypothesis used by the military governments in their military planning to analyze the actions carried out against leftist movements, including coordination between the governments of the Southern Cone. The understanding of the defense concepts against Soviet communism allows us to understand that the groups placed against the military governments were seen as a danger to the State and, in that “state of war”, the means justified the ends.

Livros da subversão: imprensa comunista e a coleção História Nova do Brasil

The colection História Nova do Brasil, produced and published in the early 1960s by a group of intellectuals of the Instituto Superior de Estudos Brasileiros (ISEB), has become a field of discussion and debate among military and the left after 1964. Accused of promoting communist subversion, the collection had a new methodology to analyze the history of Brazil, with marxist approach. For this and other reasons, copies were seized by military agencies and the authors were indicted in military investigations, accused of violating the National Security Law.

Vivencias de sujetos en procesos transexualizadores y sus relaciones con el espacio urbano de Santiago de Chile

Pós-graduação em Geografia - FCT

Conversa de senhoras: a performance do feminino em Ana Cristina Cesar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A representação do salazarismo em Afirma Pereira, de Antonio Tabucchi

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)