Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients

The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being recognized in Brazilian and French patients, respectively. The GPGR (P) motif was predominant in French but not in Brazilian patients (53.5% vs 31.0%), whereas the GWGR (W) motif was frequent in Brazilian patients (23.0%) and absent in French patients. Three tip motif groups were considered: P, W, and non-P non-W groups. The distribution of HIV-1 isolates into the three groups was significantly different between isolates from Botucatu and from Montpellier (P < 0.001). A higher proportion of CXCR4-using HIV-1 (X4 variants) was observed in the non-P non-W group as compared with the P group (37.5% vs 19.1%), and no X4 variant was identified in the W group (P < 0.001). The higher proportion of X4 variants in the non-P non-W group was essentially observed among the patients from Montpellier, who have been infected with HIV-1 for a longer period of time than those from Botucatu. Among patients from Montpellier, CD4+ cell counts were lower in patients belonging to the non-P non-W group than in those belonging to the P group (24 cells/µL vs 197 cells/µL; P = 0.005). Taken together, the results suggest that variability of the V3 loop tip motif may be related to HIV-1 coreceptor usage and to disease progression. However, as analyzed by a bioinformatic method, the substitution of the V3 loop tip motif of the subtype B consensus sequence with the different tip motifs identified in the present study was not sufficient to induce a change in HIV-1 coreceptor usage.

As mulheres de Klaxon: o universo feminino a partir dos modernistas

Pós-graduação em Artes - IA

Nacionalismo, cosmopolitismo e afrancesamento em Mon coeur balance e Leur âme, de Oswald de Andrade e Guilherme de Almeida

Pós-graduação em História - FCLAS

Arte-experimento: o bailado narrativo de Cara-de-Bronze

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Chanson polifônica francesa: um estudo nas obras corais a capella de Claude Debussy e Maurice Ravel

Pós-graduação em Música - IA

Discurso, resistência e identidade: o rock brasileiro dos anos 1980

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O pop rock e a escritura poética em Voyages de l’Autre Côté, de Jean-Marie Gustave Le Clezio

A literatura contemporânea expressa o rompimento das fronteiras entre a cultura erudita e a cultura de massa ou comercial, criando formas híbridas que convivem no interior do texto. No romance Voyages de l’autre cote (1975), de Jean-Marie Gustave Le Clézio, as canções do pop rock embalam as viagens da fada Naja Naja e de seus amigos em busca do ‘outro lado’. Desta forma, a impregnação da música popular à escritura poética, parece ajudar a libertar a imaginação, preparando as personagens para o encontro do infinito sensível.

A contribuição do canto para a voz falada do ator

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Polymorphic Sites at the 3 ' Untranslated Region of the HLA-G Gene Are Associated with Differential hla-g Soluble Levels in the Brazilian and French Population

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)