Metodologia para germina����o de sementes de Leonurus sibiricus L

O objetivo do trabalho foi investigar a influ��ncia de diferentes temperaturas, o comportamento fotobl��stico e a absor����o de ��gua de sementes de Leonurus sibiricus L. Essa esp��cie medicinal �� origin��ria da ��ndia, distribu��da pela ��sia, ��frica e Am��rica, utilizada no tratamento de reumatismo, problemas dermatol��gicos e respirat��rios. Para tanto, as sementes foram submetidas a temperaturas entre 5 a 40��C, com intervalos de 5��C, e alternadas de 20/30, 20/25 e 25/30��C, com 5 repeti����es de 50 sementes cada, em condi����es de luz e escuro. No estudo da absor����o de ��gua as sementes foram colocadas para germinar na temperatura de 20��C e na presen��a da luz e pesadas para avaliar o ganho de ��gua durante todo o processo germinativo, at�� a protrus��o da rad��cula. Pelos resultados verificou-se que os maiores porcentuais de germina����o e ��ndice de velocidade de germina����o ocorreram na temperatura constante de 20��C, e nas temperaturas alternadas 20/25, 25/30, 25/30��C sob luz. Houve germina����o na temperatura m��nima de 10��C e na m��xima 40��C. No ensaio de absor����o de ��gua verificou-se que as sementes iniciam a protrus��o da rad��cula com 65 horas de exposi����o e seguem padr��o trif��sico na curva de absor����o. O modelo estat��stico ajustado para a esp��cie foi y = 1,869 (1 - 0,414 exp ( -0,201t) + exp [-2,397 + 0,037 (t - 65)], com R��= 0,9998.

Avalia����o do efeito da expans��o r��pida da maxila na via a��rea superior, por meio da nasofibroscopia: descri����o da t��cnica e relato de caso

A finalidade deste artigo �� avaliar o efeito da expans��o r��pida da maxila (ERM) na via a��rea superior. Por interm��dio de um caso cl��nico, ser�� relatado como indiv��duos com atresia da maxila e com comprometimento da fun����o naso-respirat��ria podem beneficiar-se com a ERM. Para entender melhor as altera����es morfol��gicas decorrentes do paciente com problemas respirat��rios, deve-se conhecer a anatomia e a fisiologia do sistema respirat��rio. Entretanto, n��o se pode esquecer que o tratamento deste paciente �� multidisciplinar, envolvendo o ortodontista, otorrinolaringologista e a fonoaudi��loga.

Monitoriza����o ambulatorial da press��o arterial (MAPA) em crian��as com dist��rbios respirat��rios obstrutivos pr�� e ap��s adenotonsilectomia

P��s-gradua����o em Bases Gerais da Cirurgia - FMB

Correlation between sleep and quality of life in cerebral palsy

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

S��ndrome da apn��ia obstrutiva do sono: diagn��stico e tratamento

The Syndrome Obstructive Sleep Apnea (OSA) is defined by recurrent episodes of a total or partial obstruction of the airway during sleep, considered apnea and hypopnea respectively. Considered to be increasing by increasing the number of individuals with a disorder breathing, Being continually increasing the number of individuals with a respiratory disorder, OSA can be considered a public health problem that deserves greater attention in relation to diagnoses and treatments that are being conducted. The objective of this study is through a literature review which should be evaluated during the diagnosis and etiology, consequences and treatment of respiratory disorders not adequately treated. The etiology is multifactorial and may be associated with exogenous factors or pathological and anatomical factors. In addition to the own symptoms interfere with the quality of life of the individual, depending on the intensity, OSA can trigger more serious complications. This is a complex syndrome which may have varying degrees and irreversible consequences to the body. The choice of treatment should be based on clinical conditions, the severity of the apnea, the degree of urgency of treatment and the patient's preferences, but the treatments available will not be fully effective if there are no changes in lifestyle of it. The respiratory disorders can range from a simple nasal obstruction and intermittent obstruction more severe, emphasizing the importance of a complete diagnosis, which must be multidisciplinary, through a team relationship between doctor and dentist.

Cardiovascular risk and mortality in end-stage renal disease patients undergoing dialysis: sleep study, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life: a prospective, double blind, randomized controlled clinical trial

Background: Chronic kidney disease (CKD) is one of the most serious public health problems. The increasing prevalence of CKD in developed and developing countries has led to a global epidemic. The hypothesis proposed is that patients undergoing dialysis would experience a marked negative influence on physiological variables of sleep and autonomic nervous system activity, compromising quality of life.Methods/Design: A prospective, consecutive, double blind, randomized controlled clinical trial is proposed to address the effect of dialysis on sleep, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life in patients with CKD. The measurement protocol will include body weight (kg); height (cm); body mass index calculated as weight/height(2); circumferences (cm) of the neck, waist, and hip; heart and respiratory rates; blood pressures; Mallampati index; tonsil index; heart rate variability; maximum ventilatory pressures; negative expiratory pressure test, and polysomnography (sleep study), as well as the administration of specific questionnaires addressing sleep apnea, excessive daytime sleepiness, depression, anxiety, stress, and quality of life.Discussion: CKD is a major public health problem worldwide, and its incidence has increased in part by the increased life expectancy and increasing number of cases of diabetes mellitus and hypertension. Sleep disorders are common in patients with renal insufficiency. Our hypothesis is that the weather weight gain due to volume overload observed during interdialytic period will influence the degree of collapsibility of the upper airway due to narrowing and predispose to upper airway occlusion during sleep, and to investigate the negative influences of haemodialysis in the physiological variables of sleep, and autonomic nervous system, and respiratory mechanics and thereby compromise the quality of life of patients.

Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)

The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities

It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial pressure levels. Sympathetic oscillations coupled to the respiratory activity have been suggested as an important homeostatic mechanism optimizing tissue perfusion and blood gas uptake/delivery. This respiratory-sympathetic coupling is strengthened in conditions of blood gas challenges (hypoxia and hypercapnia) as a result of the synchronized activation of brainstem respiratory and sympathetic neurons, culminating with the emergence of entrained cardiovascular and respiratory reflex responses. Studies have proposed that the ventrolateral region of the medulla oblongata is a major site of synaptic interaction between respiratory and sympathetic neurons. However, other brainstem regions also play a relevant role in the patterning of respiratory and sympathetic motor outputs. Recent findings suggest that the neurons of the nucleus of the solitary tract (NTS), in the dorsal medulla, are essential for the processing and coordination of respiratory and sympathetic responses to hypoxia. The NTS is the first synaptic station of the cardiorespiratory afferent inputs, including peripheral chemoreceptors, baroreceptors and pulmonary stretch receptors. The synaptic profile of the NTS neurons receiving the excitatory drive from afferent inputs is complex and involves distinct neurotransmitters, including glutamate, ATP and acetylcholine. In the present review we discuss the role of the NTS circuitry in coordinating sympathetic and respiratory reflex responses. We also analyze the neuroplasticity of NTS neurons and their contribution for the development of cardiorespiratory dysfunctions, as observed in neurogenic hypertension, obstructive sleep apnea and metabolic disorders.

Respiratory immunohistochemical study in rats exposed to cigarette smoke and alcohol

Funda����o de Amparo �� Pesquisa do Estado de S��o Paulo (FAPESP)