Effect of isotretinoin on tooth germ and palate development in mouse embryos.

Vitamin A and its derivatives, retinoic acid, tretinoin and isotretinoin, are currently used in dermatological treatments. The administration of high doses of this vitamin provokes congenital malformations in mice: cleft palate, maxillary and mandibular hypoplasia and total or partial fusion of the maxillary incisors. This study compares the tooth germs of the first maxillary and mandibular molars of fetal mice submitted to isotretinoin during organogenesis. Twelve 60-day-old female Mus musculus were divided into two groups on the 7th day of pregnancy: treated group--1 mg isotretinoin per kg body weight, dissolved in vegetable oil, was administered from the 7th to the 13th day of pregnancy; control group--vegetable oil in equivalent volume was administered orally for the same period. On the 16th day of pregnancy, the females were sacrificed, the fetuses were removed and their heads amputated. After standard laboratory procedures, 6-micron thick serial slices were stained with hematoxylin and eosin for optical microscopy examination. The results showed that both groups had closed palates with no reminiscence of epithelial cells; however, the first molar germs of the isotretinoin-treated animals showed delayed development compared to the control animals.

O gênero conto em Lives of Girls and Women: o labirinto de vozes em Heirs of the Living Body

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Quenta Sol: a história e a memória de uma comunidade negra através da sua oralidade

Pós-graduação em História - FCHS

A representação da metamemória no romance brasileiro: um olhar sobre Olho de rei, de Edgard Telles Ribeiro, e Leite derramado, de Chico Buarque

Pós-graduação em Letras - FCLAS

A experiência do idoso com fratura de fêmur

Pós-graduação em Saúde Coletiva - FMB

Arquivo e Memória de Negros

This work analizes the documentation produced by the Municipal Council of Black people in Brazil, both as archival documents and as a rescue innitiative of blacks’ memory. For this purpose, we used the interdisciplinary basis of archival science, the concept of social memory and the history of black movements in Brazil. Legal aspects of Black People Council foundation were raised to provide an understanding of the relations it established with the local government and the municipal city hall. The study of Black movements was fundamental to understand the constitution of this archive, which ensures, in some way, the identity and social participation of black people, beyond the reminiscence of past events from the black people’ group experience. Thus we perceive how the black movement becomes official and legal through the documentation associated to local government; and, in the same way, we observe how their official memory is constituted.