Avaliação Histológica e histomorfométrica do reparo ósseo em tíbias osteotomizadas de ratos (rattus novergicus albinus), submetidos a tratamento com ultrassom, frente à presença e ausência de carga

The response of bone metabolism is directly related to hormonal factors and mechanical stimuli that the bone is exposed. The ultrasonic energy on bone healing have been shown to be crucial for the stimulation and improvement in quality of newly formed tissue. The aim of this study was to analyze the action of low intensity ultrasound on bone healing of tibial osteotomy in rats subjected to tail suspension, through histological analysis and histomorphometry. Eighteen Rattus norvegicus albinos, Wistar, adults were divided into three groups, arranged as follows: G1 (n = 6), who remained free for a period of 15 days, G2 (n = 5), suspended by the tail for a period of 15 days and G3 (n = 7), suspended by the tail for a period of 36 days. In all three groups, both tibias were subjected to mono-cortical bone injury 4X2 mm in the medial region of the diaphysis, and the left limb was used as control and the right limb undergoing treatment with ultrasound (U.S.). The right tibia was treated with pulsed ultrasound at a frequency of 1.5 MHz, duty cycle 1:4, 30mW/cm2, for 12 sessions of 20 minutes each. Samples of tibia were subjected to histological analysis, blindly, with light microscopy and histomorphometric analysis by specific software Image-Pro 6.1. The average percentage of new bone formation were subjected to analysis of variance in subdivided parcels and multiple comparison test "Student-Newman-Keuls (SNK), with a significance level of 5%. The average values and standard deviations of the percentage of newly formed bone for the groups showed the least amount of bone repair G1t (13.62% ± 4.88%) - G1c (8.68% ± 4.16%) compared G2t groups (27.17% ± 11.36%) - G2c (10.10% ± 7.90%) and G3t (23.19% ± 5.61%) - G3c (15.74% ± 7 08%). However, the mean values and standard deviations of the percentage of newly formed bone repair in the tibia treated G2t and G3t were significantly higher when compared to the repair of tibia in the control group (G2c and G3c). Consequently, we conclude that ultrasound has helped to accelerate bone repair in both the presence and absence of cargo.

Osteotomia com brocas de alta e baixa rotação, com e sem refrigeração líquida: estudo histopatológico duplo cego em suínos

Nine swines of the White Large race were used for study of the process of bony repair after osteotomy with rotating instruments of low and high-speed, with and without liquid refrigeration. The authors observed, through double blind histopathological analysis, that in every analyzed operative time, the bony repair was processed more appropriately when the osteotomies were accomplished with liquid refrigeration. In the final postoperative times, of fourteen and twenty-eight days, the best results of bony repair were observed in the osteotomy accomplished with drills of low rotation and with liquid refrigeration, while in the postoperative time of seven days, the results of the bony repair of osteotomy accomplished with drills of high rotation and with liquid refrigeration they were better. The authors consider, still, that the process of bony repair in swine display larger proximity in the histological pictures among the studied variables, when compared with other biological models. As most of the works told in the literature it refers the use of dogs, the authors consider that the present work guarantees your importance in the sense of looking for a closer model of the man.

Opiniões e atitudes dos médicos frente às ações promocionais da indústria farmacêutica

The pharmaceutical industry invests heavily in promoting their products, and studies suggest that these actions influence doctor’s prescribing. Therefore, this study aimed to analyze the opinions and attitudes of doctors when facing promotional activities of the laboratories. To this end, questionnaires were sent to doctors in Araraquara (SP) containing statements on the subject. Data analysis included study of the association by the chi-square. The results indicated that physicians relate to the propagandists (98%) by considering them useful (55%), but not as a main source update (86%). For 62% of them their prescriptions are not influenced by such relationships, while 24% disagree that doctors in general are influenced as well as new graduates (37%). The majority also disagrees that are influenced by amenities (86%) or free samples (70%) but only 38% believe their colleagues are not influenced by the samples. As for the ethics of these receipts, 57% considered to be appropriate when benefit patients, but only 32% while for personal use. The results show that doctors are vulnerable to the influences of marketing. Therefore, mechanisms and interventions are needed for prescribing drugs solely by criteria of effectiveness, safety, convenience and accessibility to the patient.