An open-label, comparative study of the efficacy and safety of once-daily dose of enoxaparin versus unfractionated heparin in the treatment of proximal lower limb deep-vein thrombosis

Background: Treatment of deep-vein thrombosis (DVT) with a once-daily regimen of enoxaparin, rather than a continuous infusion of unfractionated heparin (UFH) is more convenient and allows for home care in some patients. This study was designed to compare the efficacy and safety of these two regimens for the treatment of patients with proximal lower limb DVT. Methods: 201 patients with proximal lower limb DVT from 13 centers in Brazil were randomized in an open manner to receive either enoxaparin [1.5 mg/kg subcutaneous (s.c.) OD] or intravenous (i.v.) UFH (adjusted to aPTT 1.5-2.5 times control) for 5-10 days. All patients also received warfarin (INR 2-3) for at least 3 months. The primary efficacy endpoint Was recurrent DVT (confirmed by venography or ultrasonography), and safety endpoints included bleeding and serious adverse events. The rate of pulmonary embolism (PE) was also collected. Hospitalization was at the physician's discretion. Results: Baseline patient characteristics were comparable between groups. The duration of hospital stay was significantly shorter with enoxaparin than with UFH (3 versus 7 days). In addition, 36% of patients receiving enoxaparin did not need to be hospitalized, whereas all of the patients receiving UFH were! hospitalized. The treatment duration was slightly longer with enoxaparin (8 versus 7 days). There was a nonsignificant trend toward a reduction in the rate of recurrent DVT with enoxaparin versus UFH, and similar safety. Conclusions: A once-daily regimen of enoxaparin 1.5 mg/kg subcutaneous is at least as effective and safe as conventional treatment with a continuous intravenous infusion of UFH. However, the once daily enoxaparin regimen is easier to administer (subcutaneous versus intravenous), does not require aPTT monitoring, and leads to both a reduced number of hospital admissions and an average 4-day-shorter hospital stay. (C) 2004 Elsevier Ltd. All rights reserved.

O sentido da autoridade nas destituições do poder familiar em Marília a partir dos relatos dos operadores do direito na perspectiva do gênero

Pós-graduação em Ciências Sociais - FFC

Características da interface dos sites de notícias: um estudo do design e da usabilidade de jornais impressos e eletrônicos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Teorias do agrupamento sonoro: propriedades e condições de existência de elementos sonoros temporalmente discrimináveis e o essencialismo na construção de conceitos da teoria musical

Pós-graduação em Música - IA

A corte interamericana de Direitos Humanos e a implementação de políticas públicas brasileiras

Pós-graduação em Direito - FCHS

Entre permanências e descontinuidades: o levante “constitucionalista” de 1932 e a batalha contra o esquecimento

Problematizar a memória do levante “constitucionalista” de 1932 gravada materialmente nas ruas e praças de São Paulo, refletir sobre os lastros históricos que a compõem, intentando aferir as mudanças e permanências que o tempo e a sociedade se encarregaram de fomentar, são algumas das questões abordadas neste artigo. Para levá-las a efeito, as trilhas abertas pelo marco aos voluntários de 32, no município de Assis, parecem alvissareiras, – seja pelos traços que conserva de seu período de fundação, pela leitura histórica nele inscrita ou, ainda, o estado atual em que se encontra – desvelando os complexos meandros dos processos de “enquadramento da memória”, da luta pela preservação e o arbítrio do esquecimento.

Sobre o controle jurisdicional da política externa - notas acerca do caso Battisti no STF

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Mulheres e tatuagens: valores e intenções impregnados na construção do corpo feminino

Pós-graduação em Educação Sexual - FCLAR

Julgamento de adolescentes sobre pessoas fumantes e não fumantes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Perda de carga em reduções concêntricas de PVC

In the pumping pipelines the located load losses are very important since they have direct influence on hydraulic design of an irrigation system, especially regarding the concentric reducers used in the distribution lines. Hence this work was conducted in the Laboratório de Hidráulica do Centro Federal de Educação Tecnológica de Uberaba. We analyzed 03 concentric reducers PVC 75 x 50 mm, 50 mm and 35 x 35 x 1 "operating at different flow rates. The performance of the tests with the variation of flow in every situation possible to obtain equations to estimate the loss. The equation models presented a high setting, thus enabling the determination of the localized head loss in a situation closer to field reality. For the reduction of 75 x 50 x 35 mm and 50 mm at a flow rate 16.97 m³ h-1 the pressure drop reduction was obtained respectively 0.9263 and 2.7408 mca. To the reduction of 35 x 1 "at a flow rate of 6.02 m³ h-1 was obtained 2.9304 mca pressure drop reduction. The located losses produced by these reductions are relatively high and should be considered with great discretion in hydraulic design of the irrigation system.