El papel del óxido nítrico en la modulación del proceso inflamatorio de la enfermedad periodontal

Nitric oxide (NO) is a free radical with participation in almost all physiologic host processes; however, in high concentrations it may damage the tissues. Its immunoregulatory action is present in the inflammation and in auto-immune mechanisms, being intensively studied in the medical area. Recently, some studies have also reported that NO could play a role as etiopathogenic factor of the periodontal disease, which shows inflammatory and multifactorial course. Due to beneficial or damage effects of NO, according to its concentrations, some studies have been focused in the evaluation of inhibitor of NO-Synthase (NOS) as therapeutic agents in inflammatory processes. In this context, the aim of this study was to report the role of NO and NOS inhibition in the periodontal disease modulation process. In conclusion, it could be suggested that NO seems to play an essential role in evolution of inflammatory periodontal disease, and that the NOS inhibition may be considered as a promising therapeutic in modulation of inflammatory process.

Palimpsestos: Ana Miranda y la lectura de la historia literarria brasileña

We can notice in Brazilian literature —both past and contemporary— the presence of the historical novel in its several modalities which include traditional models but also contemporary formulations that break old models with irreverence. Among them are the historiographical metafictions (Hutcheon, 1991), which propose the rereading not only of history but also of literature itself. Therefore, in the large number of historical characters which are fictionalized by contemporary Brazilian historical novel in the last decades, this essay intends to discuss how Ana Miranda engages in reading the history of Brazilian literature through fiction in three of her novels. The first is Boca do inferno (1989), whose protagonists are two of the main representatives of Brazilian colonial barroque, Father Antônio Vieira and poet Gregório de Matos. Following the chronological order of protagonist writers, the next novel to be discussed is Dias & dias (2002), whose action is centered in Gonçalves Dias, a well known poet of national Romanticism. The third is A última quimera (1995), which makes an outline of Brazilian literature at the beginning of the 20th century, dealing with Augusto dos Anjos and Olavo Bilac. By inverting some traditional viewpoints, Ana Miranda proposes, as in a palimpsest, the rereading and discussion of the national literary cânon and its construction.