Intravenous procedural sedation: an alternative in the treatment of patients with intellectual disability

Conscious sedation has become established as an important alternative to general anesthesia (GA) in dental treatment of patients with intellectual disability (ID). Aim: to investigate dental patients undergoing sedation using a mean dose of 0.6 mg/kg intravenous midazolam and the adverse events of sedation in patients with ID. Methods: This study analyzed the records of 163 dental patients with ID aged between 2 and 76 years who had undergone conscious intravenous sedation (CIV) using a mean dose of 0.61 mg/kg of midazolam at Araçatuba Dental School, São Paulo State University, Brazil. The efficacy and complications induced by CIV were evaluated in each subject. Results: CIV was effective for dental treatment in 80% of the cases. A total of 626 dental procedures were performed. The mean treatment time was 33.9 minutes. There was statistically significant difference (p<0.05) between absence and presence of adverse reactions. Adverse reactions were observed in 21.47% of the cases. Conclusions: The results of this study showed that CIV is a useful method for dental treatment of patients with ID and these patients can need higher doses of sedative to reach an adequate level of sedation.

Hermit crabs as bioindicators of recent tributyltin (TBT) contamination

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of recombinant bovine somatotropin (bST) on follicular population and on in vitro buffalo embryo production

The objective of this study was to evaluate the effect of bovine somatotropin (bST) on ovarian follicular population in buffalo heifers and its influence on oocyte quality, recovery rates and in vitro embryo production. We tested the hypothesis that bST treatment in buffalo females submitted to an ovum pick-up (OPU) program Would improve the number of follicles recruited, oocyte quality and in vitro embryo production. A total of 10 heifers were assigned into two treatment groups: group bST (n = 5; receiving 500 mg of bST in regular intervals) and control group (n = 5; without additional treatment). Both groups were subjected to OPU sessions twice a week (every 3 or 4 days), for a total of 10 sessions per female, although due to procedural problems, only the first five OPU sessions produced embryos. The number of follicles and the diameters were recorded at all OPU sessions. The harvested oocytes were counted and classified according to their quality as either A, B, C, D or E, with A and B considered good quality. Cleavage and blastocyst production rates were evaluated 2 and 7 days after in vitro fertilization, respectively. The bST treatment increased the total number of antral follicles (> 3 mm in diameter; 12.2 compared with 8.7: p, < 0.05) and of small antral follicles (< 5 mm; 9.1 compared with 6.5; p < 0.05) per OPU session. The bST also tended to increase the number of oocytes recovered per session (5.2 compared with 4.1; p = 0.07), and enhanced the percentage of good quality oocytes (48.8% compared with 40.6%; p = 0.07), bST showed no effect on cleavage and blastocyst production rates (p > 0.05). The significant effects of performing repeated OPU sessions were decreasing the follicular population (p < 0.001) as well as the number of follicles aspirated (p < 0.001), and oocytes recovered (p < 0.02). In conclusion, bST treatment improves the follicular population, demonstrating its possible application in buffalo donors submitted to OPU programs. (c) 2008 Elsevier B.V. All rights reserved.

Resiliência no trabalho contemporâneo: promoção e/ou desgaste da saúde mental

Este estudo teórico resgata a concepção processual e contextual de resiliência, a qual compreende esse fenômeno enquanto relação complexa entre indivíduo e ambiente na produção de fatores de risco e no provimento de fatores protetores da subjetividade do indivíduo, buscando aplicá-la à realidade organizacional, haja vista que o mundo do trabalho contemporâneo demanda uma força de trabalho específica, qual seja, o trabalhador flexível, polivalente, sujeito a mudanças - portanto, um trabalhador resiliente. A partir dessas considerações, realiza-se um processo de reflexão sobre as situações em que a resiliência pode ser promotora de saúde mental, bem como acerca dos contextos que contribuem para o processo de adoecimento do trabalhador, buscando aventar possibilidades de atuação do profissional psicólogo diante de um contexto de trabalho adverso, considerando-se que o principal objetivo dessa atuação profissional é garantir a proteção/promoção da saúde e qualidade de vida no ambiente de trabalho.

Modelos de tomada de decisão e sua relação com a informação orgânica

O processo decisório compreende a aplicação de diferentes modelos de tomada de decisão, cada um deles pertinente a uma determinada situação. Entre eles, destacamos como principais os modelos racional, processual, anárquico e político. Para este trabalho, utilizamos os conceitos de Choo (2003), por se tratar de uma das principais obras a respeito do tema existente na literatura e, assim, analisamos cada um dos modelos propostos pelo autor. A partir da análise dos modelos, foi possível estabelecer relações entre eles e maneira pela qual a informação orgânica - produzida internamente à organização, participa do processo decisório, mais especificamente no âmbito de cada modelo. Por último, a partir das inferências realizadas, propomos um novo modelo de tomada de decisão, cuja base de sustentação é a informação orgânica.

Avaliação: um contrato de trabalho

Este artigo apresenta, tendo em vista perplexidades constituídas a partir de uma leitura acerca do funcionamento do modelo tradicional de ensino, considerações sobre a Proposta Pedagógica Assimilação Solidária, AS (Baldino, 1995a). Proposta interventora, a AS muda o conceito de mérito, pois considera, ao lado do prêmio ao saber, o justo prêmio ao trabalho coletivo produzido em sala de aula. O instrumento fundamental da AS é um contrato de trabalho, negociado entre professor e alunos, que vincula a avaliação e o trabalho em grupos na sala de aula.

Use of the elevated T-maze to study anxiety in mice

We have recently suggested that the elevated T-maze (ETM) is not a useful test to study different types of anxiety in mice if a procedure similar to that originally validated for rats is employed. The present study investigated whether procedural (five exposures in the enclosed arm instead of three as originally described for rats) and structural (transparent walls instead of opaque walls) changes to the ETM leads to consistent inhibitory avoidance acquisition (IAA) and low escape latencies in mice. Results showed that five exposures to the ETM provoked consistent IAA, an effect that was independent of the ETM used. However, the ETM with transparent walls (ETMt) seemed to be more suitable for the study of conditioned anxiety (i.e. IAA) and unconditioned fear (escape) in mice, since IAA (low baseline latency with a gradual increase over subsequent exposures) and escape (low latency) profiles rendered it sensitive to the effects of anxiolytic and anxiogenic drugs. In addition to evaluation of drug effects on IAA and escape, the number of line crossings in the apparatus were used to control for locomotor changes. Results showed that whereas diazepam (1.0-2.0 mg/kg) and flumazenil (10-30 mg/kg) impaired IAA, FG 7142 (10-30 mg/kg) did not provoke any behavioral change. Significantly, none of these benzodiazepine (BDZ) receptor ligands modified escape latencies. The 5-HT1A partial receptor agonist buspirone (1.0-2.0 mg/kg) and the 5-HT releaser fenfluramine (0.15-0.30 mg/kg) impaired IAA and facilitated escape, while the full 5-HT1A receptor agonist, 8-OH-DPAT (0.05-0.1 mg/kg) and the 5-HT2B/2C receptor antagonist, SER 082 (0.5-2.0 mg/kg) failed to modify either response. mCPP (0.5-2.0 mg/kg), a 5-HT2B/2C receptor agonist, facilitated IAA but did not alter escape latency. Neither antidepressant utilized in the current study, imipramine (1.0-5.0 mg/kg) and moclobemide (3.0-10 mg/kg) affected IAA or escape performance in mice. The well-known anxiogenic drugs yohimbine (2.0-8.0 mg/kg) and caffeine (10-30 mg/kg) did not selectively affect IAA, although caffeine did impair escape latencies. Present results suggest the ETMt is useful for the study of conditioned anxiety in mice. However, upon proximal threats (e.g. open arm exposure), mice do not exhibit escape behavior as an immediate defensive strategy, suggesting that latency to leave open arm is not a useful parameter to evaluate unconditioned fear in this species. (C) 2003 Elsevier B.V. All rights reserved.

Orçamento participativo e gestão democrática no poder local

The end of the authoritarian regime in Brazil resulted in new forms of democratization of politics and its institutions, with the strenghtening of the civil society. The Participatory Budgeting is an important experience of that new way, characterized by the assumption of the new responsibilities by the local governments. The comparative approach of those experiences, conducted from different party coalitions - in Piracicaba (1989-1992) and in Santa Bárbara d'Oeste (1997-2000) -, allows a test of their powers and limits from a procedural conception of democracy and the complementary role of the participation. In contrast to a view that gives priority to representation, the analysis discusses the range of the new civil society actions from the perspective of the democratization process in the scope of the Local Government. © 2007 CEDEC.

The Owner Share scheduler for a distributed system

In large distributed systems, where shared resources are owned by distinct entities, there is a need to reflect resource ownership in resource allocation. An appropriate resource management system should guarantee that resource's owners have access to a share of resources proportional to the share they provide. In order to achieve that some policies can be used for revoking access to resources currently used by other users. In this paper, a scheduling policy based in the concept of distributed ownership is introduced called Owner Share Enforcement Policy (OSEP). OSEP goal is to guarantee that owner do not have their jobs postponed for longer periods of time. We evaluate the results achieved with the application of this policy using metrics that describe policy violation, loss of capacity, policy cost and user satisfaction in environments with and without job checkpointing. We also evaluate and compare the OSEP policy with the Fair-Share policy, and from these results it is possible to capture the trade-offs from different ways to achieve fairness based on the user satisfaction. © 2009 IEEE.

Context-sensitive analysis of obfuscated x86 executables

A method for context-sensitive analysis of binaries that may have obfuscated procedure call and return operations is presented. Such binaries may use operators to directly manipulate stack instead of using native call and ret instructions to achieve equivalent behavior. Since definition of context-sensitivity and algorithms for context-sensitive analysis have thus far been based on the specific semantics associated to procedure call and return operations, classic interprocedural analyses cannot be used reliably for analyzing programs in which these operations cannot be discerned. A new notion of context-sensitivity is introduced that is based on the state of the stack at any instruction. While changes in 'calling'-context are associated with transfer of control, and hence can be reasoned in terms of paths in an interprocedural control flow graph (ICFG), the same is not true of changes in 'stack'-context. An abstract interpretation based framework is developed to reason about stack-contexts and to derive analogues of call-strings based methods for the context-sensitive analysis using stack-context. The method presented is used to create a context-sensitive version of Venable et al.'s algorithm for detecting obfuscated calls. Experimental results show that the context-sensitive version of the algorithm generates more precise results and is also computationally more efficient than its context-insensitive counterpart. Copyright © 2010 ACM.

Context-sensitive analysis without calling-context

Since Sharir and Pnueli, algorithms for context-sensitivity have been defined in terms of 'valid' paths in an interprocedural flow graph. The definition of valid paths requires atomic call and ret statements, and encapsulated procedures. Thus, the resulting algorithms are not directly applicable when behavior similar to call and ret instructions may be realized using non-atomic statements, or when procedures do not have rigid boundaries, such as with programs in low level languages like assembly or RTL. We present a framework for context-sensitive analysis that requires neither atomic call and ret instructions, nor encapsulated procedures. The framework presented decouples the transfer of control semantics and the context manipulation semantics of statements. A new definition of context-sensitivity, called stack contexts, is developed. A stack context, which is defined using trace semantics, is more general than Sharir and Pnueli's interprocedural path based calling-context. An abstract interpretation based framework is developed to reason about stack-contexts and to derive analogues of calling-context based algorithms using stack-context. The framework presented is suitable for deriving algorithms for analyzing binary programs, such as malware, that employ obfuscations with the deliberate intent of defeating automated analysis. The framework is used to create a context-sensitive version of Venable et al.'s algorithm for analyzing x86 binaries without requiring that a binary conforms to a standard compilation model for maintaining procedures, calls, and returns. Experimental results show that a context-sensitive analysis using stack-context performs just as well for programs where the use of Sharir and Pnueli's calling-context produces correct approximations. However, if those programs are transformed to use call obfuscations, a contextsensitive analysis using stack-context still provides the same, correct results and without any additional overhead. © Springer Science+Business Media, LLC 2011.

Avaliação de acessibilidade e informações sobre políticas públicas para pessoas com deficiência em portais eletrônicos de governo paulistas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Responsabilidade do Estado e do magistrado frente à concessão ou denegação de tutelas de urgência

Pós-graduação em Direito - FCHS

Danos morais: compensabilidade e quantificação

Pós-graduação em Direito - FCHS

Inovações do Código de Processo Civil e seus reflexos no Direito Processual do Trabalho: uma análise crítica das leis n.10352/01, n.10358/01, n.10444/02, n.11187/05, 11232/05, n.11276/06, n.11277/06, n.11280/06 e n.11382/06

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)