Decreased Sperm Motility in Rats Orally Exposed to Single or Mixed Pesticides

The Brazilian Agency of Sanitary Vigilance (ANVISA) conducted a study that demonstrated the presence of residues of several pesticides in fresh fruits and vegetables that were available for purchase by the general populace. In order to evaluate potential adverse health effects of low-level exposure to agrochemicals, the reproductive toxicity of the pesticides dicofol, dichlorvos, permethrin, endosulfan, and dieldrin was evaluated in rats dosed with these chemicals individually or as mixtures. Sixty male Lewis rats (6 wk old, 200 x g) were randomly allocated to 8 groups: (1) control group, received basal diet; (2) 5 groups designated a to e received the diet containing each pesticide individually, at the respective effective doses: lowest-observed-adverse-effect level (LOAEL) for dieldrin and endosulfan, lowest-observed-effect level (LOEL) for dicofol, and lowest effect level (LEL) for dichlorvos and permethrin, respectively, depending on the published data; (3) effective dose group, which received a mixture of pesticides added to basal diet at the respective doses reported to produce adverse effects; and (4) low dose group, which received a pesticide mixture added to the basal diet, where each pesticide was at its no-observed-effect level (NOEL). After 8 wk of treatment, reproductive parameters were evaluated. Sperm morphology, daily sperm production (DSP), sperm transit time through the epididymis, hormonal levels, and histopathological evaluation of testis and epididymis did not differ significantly among the groups. However, sperm motility was significantly decreased in animals that received a mixture of dieldrin, endosulfan, dicofol, dichlorvos, and permethrin, as well as in the group receiving dicofol alone. Exposure to the individual pesticides endosulfan, dichlorvos, and permethrin did not markedly affect sperm motility. The impairment of sperm motility in the mixture of pesticides at the NOEL level indicates that reproductive effects not seen with individual pesticides may occur in presence of several pesticides due to an additive effect. However, the pesticide mixtures did not appear to affect DSP or spermatogenesis despite reduced sperm motility.

Lima, uma cidade entre a aristocracia e a plebe (1950-1980)

The city of Lima has undergone serious changes over the past sixty years. Until the middle of the last century, Lima retained an urban structure similar to that built in the 18th century, during the final decades of its colonial period. This reality began to change with the abrupt onset of migration from the mountain ranges to the coast in 1946. However, rather than changes in its urban plan, Lima underwent a ethnic and social reconfiguration that would bring new color and new cultural and behavioral norms to the Peruvian capital. The arrival of migrants to the city caused a conservative reaction in the local elites, but it also sparked a need for the intelligentsia to develop new ways of thinking about the place of migrants in the space of the city, and on the other hand, to create new representations of the city itself. From being a city isolated from the rest of the country, Lima came to live with a range of cultural and ethnic references. It did so, however, without creating greater opportunities for the integration of the masses within the urban and social logic of the city, thus making clear the separation between the aristocracy and the general populace.

Garimpo do Araras/RO depois do Eldorado

Pós-graduação em Geociências e Meio Ambiente - IGCE