Análise retrospectiva da toxicidade de gotas otológicas, medicamentos tópicos nasais e orofaríngeos registrada na Grande São Paulo.

BACKGROUND: Retrospective analysis of human toxicity files involving topical medicines for treatment of upper airways diseases (eardrops, topical nasal medicines, lozenges, drops and sprays for oropharyngeal affections). METHODS: Thirty-four brands of eardrops, 48 of topical nasal medicines and 22 of tablets, lozenges and sprays for oropharyngeal affections were selected, from a total of 104 products available in Brazil. We analyzed the registries in the electronic database from the Poison Control Centre of São Paulo (CCI-Jabaquara), Brazil, for the period from January 1996 through December 2000. The cases related to selected pharmaceuticals were collected. RESULTS: 10,823 cases of human toxicity caused by medicines were voluntarily reported to CCI-Jabaquara. Topical medicines for treatment of upper airways diseases accounted for 291 cases (2.68%), from which 240 (82.5%) represented poisoning; 12 (4.1%) involved ear drops, 268 (92%), topical nasal medicines and 11 (3.9%), topical medicines for oropharyngeal affections. Among topical nasal medicines, vasoconstrictors predominated (233 cases), and among medicines for oropharyngeal affections, it was tetracaine (four cases). Considering age distribution, toxicity predominated significantly in children aged from 1 to 4 years (p=0.0003). The main causes of toxicity were: accidental intake of medicines (43%) and error in drug administration (14.8%). Hypereflexia and vomiting were the most frequent symptoms related to toxicity. CONCLUSIONS: There was significant incidence of systemic toxicity due to eardrops, topical nasal and oropharyngeal medicines in children 1 to 4 years-old, whose main cause was accidental intake of these medicines.

Analgésicos Tópicos

Background and objectives: Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administration of analgesics is an alternative. The objective of this paper is to discuss topical analgesics, the mechanisms of action and clinical efficacy. Content: This is a review paper addressing the usage of the topical local anesthetics: capsaicin, clonidine, tricyclic antidepressants, ketamine, opioids and cannabinoids, discussing mechanism of action and effectiveness. Conclusions: Topical analgesics are promising as a strategy for pain treatment, as they are associated with lower incidence of side effects. The benefit of local anesthetics, NSAID's and capsaicin is well established. However, the efficacy of clonidine, tricyclic antidepressants, ketamine, opioids and cannabinoids is still questionable. Studies have shown that the multimodal approach is an alternative, but studies are needed to confirm this hypothesis. © 2012 Elsevier Editora Ltda.

Paradigmas diversos no campo da assistência social e seus estabelecimentos assistenciais típicos

In order to understand what is the situation of entities that serve children and adolescents today, as well as the institutional plot that comprises these institutions, we aimed to formulate a set of paradigmatic possibilities that would allow us to understand the configuration of the dialectical field of various pulses, in which these entities are located. We detected the subjects we associate with counterparts paradigms of Charity, of Human Promotion, of Philanthropy, of assistentialist government patronage, of Social Work as a State Policy, and finally, another set of events that we propose to designate as the paradigm of Citizen Subjects we associate with the ethical perspective of People Education. These paradigmatic possibilities range from the simply various and contrasting ones, including the similar and competing ones, to the dialectically contradictory ones. Its spectrum oscillates between tutelage and citizenship. The characterization of these didactic paradigms can provide us a compass that is required in a highly complex social field, allowing us to understand the variety of ethical effects promoted by these paradigms in the social field.

Estudo duplo cego com Isoconazol e Terbinafina tópicos no tratamento de um paciente com Tinea nigra plantaris bilateral e sugestões para novos diagnósticos diferenciais

The authors report a case of bilateral Tinea nigra plantaris treated through a double-blind study with the topical antifungal agents Isoconazole and Terbinafine. The objective of the study was to clinically compare the efficacy of these two topical antifungal agents on days 10, 20 and 30 of the treatment. No significant clinical differences were found, as all the plantar lesions regressed completely by the end of the treatment. Our conclusion was that in the case reported, the topical antifungal agents Isoconazole and Terbinafine demonstrated identical efficacy as a clinical cure. We also suggest the inclusion of injuries caused by arthropods of the Diplopoda Class in the differential diagnosis of Tinea nigra plantaris, due to the persistent acral hyperpigmentation.

Tópicos de equações diferenciais parciais elípticas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Transmissão de produtos farmacêuticos tópicos através de energia ultra-sônica na regeneração de lesões da musculatura esquelética - enfoque morfológico

Pós-graduação em Ciências da Motricidade - IBRC

Influência de três hemostáticos tópicos no processo de reparo em feridas de extração dental: análise histológica e histométrica em ratos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Tópicos de equações diferenciais com retardamento: uma abordagem segundo o trabalho do Prof. Nelson Onuchic

Pós-graduação em Matemática Universitária - IGCE

Tópicos da geometria projetiva

Pós-graduação em Matemática Universitária - IGCE

Tópicos de geometria diferencial

Pós-graduação em Matemática Universitária - IGCE

(Des)concerto: o realismo maravilhoso em Concierto Barroco

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Tópicos em teoria quântica de campos

Pós-graduação em Física - IFT

Conflito político-cultural na antiguidade tardia: o levante das estátuas em Antioquia de Orantes (387 d.C.)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Sistema penal e gênero: tópicos para a emancipação feminina

Os artigos que integram este volume, frutos de atividades de pesquisa desenvolvidas na Faculdade de Ciências Humanas e Sociais da Unesp, campus Franca, discutem a emancipação feminina a partir de um mesmo enfoque científico metodológico e, principalmente, ideológico, por meio da investigação da complexa relação entre os sistemas penais e a questão do gênero. O livro discute a persistência no Direito Penal de aspectos discriminatórios e, consequentemente, ilegais, que fazem parte de uma cultura apropriadora da identidade e do corpo femininos como se fossem espaços públicos de discussão. Mostra-se, por exemplo, que na maioria dos presídios femininos descumpre-se o direito de visita íntima, ao contrário do que acontece nos masculinos. E discute-se também a mulher como vítima da exploração sexual em uma acurada análise de perfis de mulheres expostas a essa situação, bem como de aliciadores. Esta obra procura, enfim, preencher uma lacuna nos estudos sobre o Direito Penal relacionados à questão de gênero e que contestem as estruturas institucionais e normativas consolidadas.