6 resultados para Organon

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Objective: To evaluate changes in mammographic density and Tc-99m-sestamibi scintimammographic uptake in postmenopausal women on hormone replacement therapy (HRT).Methods: Seventy-five postmenopausal women were prospectively studied and allocated into three groups: 50 women were randomized to either Group 1 (G1, n = 25), which received 2 mg of 17 beta-oestradiol continuously combined with 1 mg of norethisterone acetate (E-2/NETA, Kliogest (R), Medley) or Group 2 (G2), which received 2.5 mg/day of tibolone (Livial (R), Organon). The remaining 25 women, who were asymptomatic and had no desire to undergo HRT, constituted the control group (G3). Each patient was submitted to both mammography and scintimammography at baseline and after six months. Mammographic density was evaluated by using the BI-RADS classification system. The classification system of Barros et al. was used in the interpretation of scintimammography. For statistical analysis, the Chi-square test, ANOVA and Pearson's correlation were used.Results: At six months, increased mammographic density was observed in 48% of G1, 12% of G2 and 16% of G3 patients (p < 0.001). The increase in sestamibi uptake was 56% in G1, 28% in G2 and 24% in G3 (p < 0.001). Increases in both density and uptake were significantly higher in the group on E-2/NETA than among tibolone users and the controls.Conclusion: In postmenopausal women, HRT with E-2/NETA was associated with increased mammographic density and increased Tc-99m-sestamibi scintimammographic uptakes, suggesting greater mithochondrial activity in the cells of the mammary duct. This was not observed in users of 2.5 mg of tibolone, demonstrating that the effects on the breast were reduced. The same was observed in the control group. (c) 2005 Elsevier B.V.. All rights reserved.

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This article presents the theoretical and methodological road used to construct the Historical Dictionary of Brazilian Portuguese in the XVI, XVII and XVIII centuries (sponsored by CNPq). Starting with some examples and models of historical and diachronic dictionaries we set the model that structures the Dictionary; it has the purpose of assembling in a single book the Portuguese language lexicon responsible for the construction of the Portuguese language in Brazil. Our reference basis is a data bank with many sorts of sources existing along the three centuries of the Brazilian colonial history. This data bank provides the nomenclature of the historical dictionary and allows the construction of the lexicographical definition through its lexical context that is followed by consecrated examples. This article also presents the contributions of the dictionary to future studies of the Brazilian Portuguese.

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The study of Latin is essentially focused on the receptive writing skills acquisition. For this reason, the teaching of this ancient language should have the readers’ training as its main objective. ! e e" ective understanding of ancient texts depends on a learning process that is based on three competence levels: the language level, the textual level and the intertextual level. As part of this teaching methodology, which seeks to narrow the cultural gap between the ancient and the contemporary world, avoiding anachronistic interpretation of Latin texts, this paper presents strategies that allow students to learn grammar from authentic texts.

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This article provides an analysis of Leminski’s Metaformose that establishes a remarkable re-reading of Ovid’s Metamorphoses. It is a poetic narrative published posthumously in 1994. * is work, which received “Prêmio Jabuti de Poesia” in 1995, was found among the papers of the author along with many essays, short stories, poems and a novel. * rough the author’s own theoretical conceptions, one seeks to interpretating the way the myth of Arachne is approached by him, re' ecting on the reinvention and reinterpretation of both Greek and Latin mythology and Literature in contemporary writing.

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There is a consensus among scholars that the chorus in Menander’s time had become totally detached from stage-action; its performances, marked in the Greek text by the word ΧΟΡΟΥ, separated like interludes the acts from each other within the plays; the chorus had a technical function: provide a break in the action to cover certain off-stage events and indicate the passing of time. This paper, however, examines in Dyskolos, one of Menander’s early comedies, the relation between the chorus and Cnemon present in the old man’s words that makes generalizations about human relationships, and shows that in this comedy the chorus of the followers of the god Pan was exploited by the poet as a source of achieving various dramatic effects.