Preliminary Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus

Objective. To develop widely acceptable preliminary criteria of global flare for childhood-onset systemic lupus erythematosus (cSLE).Methods. Pediatric rheumatologists (n = 138) rated a total of 358 unique patient profiles with information about the cSLE flare descriptors from 2 consecutive visits: patient global assessment of well-being, physician global assessment of disease activity (MD-global), health-related quality of life, anti-double-stranded DNA antibodies, disease activity index scores, protein: creatinine (P:C) ratio, complement levels, and erythrocyte sedimentation rate (ESR). Based on 2,996 rater responses about the course of cSLE (baseline versus followup), the accuracy (sensitivity, specificity, and area under the receiver operating characteristic curve) of candidate flare criteria was assessed. An international consensus conference was held to rank these candidate flare criteria as per the American College of Rheumatology recommendations for the development and validation of criteria sets.Results. The highest-ranked candidate criteria considered absolute changes (Delta) of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) or British Isles Lupus Assessment Group (BILAG), MD-global, P:C ratio, and ESR; flare scores can be calculated (0.5 x Delta SLEDAI + 0.45 x Delta P:C ratio + 0.5 x Delta MD-global + 0.02 x Delta ESR), where values of >= 1.04 are reflective of a flare. Similarly, BILAG-based flare scores (0.4 x Delta BILAG + Delta 0.65 x Delta P:C ratio + 0.5 + Delta MD-global + 0.02 x Delta ESR) of >= 1.15 were diagnostic of a flare. Flare scores increased with flare severity.Conclusion. Consensus has been reached on preliminary criteria for global flares in cSLE. Further validation studies are needed to confirm the usefulness of the cSLE flare criteria in research and for clinical care.

Biological and molecular characterization of an isolate of Tobacco streak virus obtained from soybeans in Brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

SnO2 nanocrystals synthesized by microwave-assisted hydrothermal method: towards a relationship between structural and optical properties

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ultrastructural evidences of the occurrence of digestion and absorption of organic solutes in bees ileum (Melipona quadrifasciata anthidioides - Hymenoptera, Apidae)

The ultrastructural aspects of the ileum of Melipona quadrifasciata anthidioides, a stingless bee whose workers obtain their protein requirements from pollen, present morphological evidences of digestion and absorption. These evidences are represented by special relationships between food particles and the bacterial nora present and between their assemblage and the ileum wall, mainly in the ileum three anterior fourths. The apical features of the epithelium also are indicative of organic material absorption.

A frágil realidade de plástico: um estudo comparativo da imagem Casa de Bonecas em henrik ibsen e katherine mansfield

Considering the importance of significations in literary works, this paper proposes a comparative study of the image of the Doll's House in Henrik Ibsen's play ADoll's House (1879), and Katherine Mansfield's short story The Doll's House, published in the book The Dove's Nest (1923), based on the theories of Gaston Bachelard and Jean Baudrillard. In both cases, one notices that the presence of this image indicatesnot only the construction of these works' environment, but also a criticism of the bourgeois model of a perfect and flawless society, as the described image refers to. However, even though this image shares the same idea in both works, it will be explored differentlyin each case, whether through the search of Nora's character in escaping social conformity as in Ibsen, or through the subtle childlike game experienced by the Kelvey sisters, asin Mansfield.

Permanent Genetic Resources added to Molecular Ecology Resources Database 1 December 2012-31 January 2013

This article documents the addition of 268 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Alburnoides bipunctatus, Chamaerops humilis, Chlidonias hybrida, Cyperus papyrus, Fusarium graminearum, Loxigilla barbadensis, Macrobrachium rosenbergii, Odontesthes bonariensis, Pelteobagrus vachelli, Posidonia oceanica, Potamotrygon motoro, Rhamdia quelen, Sarotherodon melanotheron heudelotii, Sibiraea angustata, Takifugu rubripes, Tarentola mauritanica, Trimmatostroma sp. and Wallago attu. These loci were cross-tested on the following species: Alburnoides fasciatus, Alburnoides kubanicus, Alburnoides maculatus, Alburnoides ohridanus, Alburnoides prespensis, Alburnoides rossicus, Alburnoides strymonicus, Alburnoides thessalicus, Alburnoides tzanevi, Carassius carassius, Fusarium asiaticum, Leucaspius delineatus, Loxigilla noctis dominica, Pelecus cultratus, Phoenix canariensis, Potamotrygon falkneri, Trachycarpus fortune and Vimba vimba. © 2013 Blackwell Publishing Ltd.

Cadernos íntimos diários publicados: um estudo das práticas da escrita de diários, no âmbito das práticas sociais disseminadas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Notas sobre o conceito de existência autêntica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aspectos mediadores e a identidade docente na sociedade contemporânea: o contexto do ensino de lingua portuguesa

Pós-graduação em Educação - FFC

Patrimônio da humanidade: a edificação discursiva da cidade de São Luis nas políticas de preservação do Estado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Why have land use change models for the Amazon failed to capture the amount of deforestation over the last decade?

Land cover change in the Neotropics represents one of the major drivers of global environmental change. Several models have been proposed to explore future trajectories of land use and cover change, particularly in the Amazon. Despite the remarkable development of these tools, model results are still surrounded by uncertainties. None of the model projections available in the literature plausibly captured the overall trajectory of land use and cover change that has been observed in the Amazon over the last decade. In this context, this study aims to review and analyze the general structure of the land use models that have most recently been used to explore land use change in the Amazon, seeking to investigate methodological factors that could explain the divergence between the observed and projected rates, paying special attention to the land demand calculations. Based on this review, the primary limitations inherent to this type of model and the extent to which these limitations can affect the consistency of the projections will also be analyzed. Finally, we discuss potential drivers that could have influenced the recent dynamic of the land use system in the Amazon and produced the unforeseen land cover change trajectory observed in this period. In a complementary way, the primary challenges of the new generation of land use models for the Amazon are synthesized. (c) 2014 Elsevier Ltd. All rights reserved.

The effect of biomass immobilization support material and bed porosity on hydrogen production in an upflow anaerobic packed-bed bioreactor

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Performance and composition of bacterial communiies in anaerobic fluidized bed reactors for hydrogen production: Effects of organic loading rate and alkalinity

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Memória, História e Patrimônio: perspectivas comtemporâneas da pesquisa histórica

It should be noted that the studies for some time been considering the historical importance of objects and space as components of memory - or “places of memory” in the words of Pierre Nora. The memory would thus be defi ned as an imaginary dimension of society, a mental universe that acquires and social substance that creates the individual with a “social whole” in an open line of work by M. Halbwachs. And this notion of memory allows us to grasp the question sheet. This cult of memory had its place also rise through the delimitation of national heritage - as Françoise Choay, since the establishment of categories of historical monuments in France in 1837. The discussion on equity has progressed in recent decades, as it is conceived as objects, spaces, knowledge and events become “intangible heritage” because it has reference value to the community. It is considered that the references are the property constituting the objects of memory formation, forms of work-life past or present. Anyway, heritage presents itself as the embodiment of a discourse about the past.