Detection of cytokines and nitric oxide synthase in skin lesions of Jorge Lobo's disease patients

Studies investigating the immunopathological aspects of Jorge Lobo's disease have shown that the inflammatory infiltrate consists mainly of histiocytes and multinucleated giant cells involving numerous yeast-like cells of Lacazia loboi, with the T lymphocytes more common than B lymphocytes and plasma cells. The quantification of cytokines in peripheral blood mononuclear cells culture supernatant has revealed alterations in the cytokines profile, characterized by predominance of a Th2 profile. In view of these findings and of the role of cytokines in cell interactions, the objective of the present study was to investigate the presence of the cytokines IL-10, TGF-ss 1 and TNF-alpha, as well as iNOS enzyme in granulomas induced by L. loboi. Histological sections obtained from skin lesions of 16 patients were analyzed by immunohistochemistry for the presence of these cytokines and iNOS. The results showed that TGF-ss 1 was the cytokine most frequently expressed by cells present in the inflammatory infiltrate, followed by IL-10. There was a minimum to discrete positivity of cells expressing TNF-alpha and iNOS. The results suggest that the presence of immunosuppressive cytokines in skin lesions of patients with the mycosis might be responsible for the lack of containment of the pathogen as demonstrated by the presence of numerous fungi in the granuloma.

Doença de Jorge Lobo e sua relação com os antígenos do sistema HLA

Pós-graduação em Doenças Tropicais - FMB

O simbolismo na poesia de Jorge de Lima

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A formação do tecido discursivo em A Árvore das palavras, de Teolinda Gersão, e em A Manta do soldado, de Lídia Jorge

Pós-graduação em Estudos Literários - FCLAR

Traços romanescos e épicos em Jubiabá de Jorge Amado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Os jesuítas e a escravidão africana no Brasil colonial: um estudo sobre os escritos de Antonio Vieira, André João Antonil e Jorge Benci: sécs. XVII e séc. XVIII

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Jorge Amado e a consciência discursível em A morte e a morte de Quincas Berro D'água

Pós-graduação em Letras - FCLAS

O leitor nas trilhas do texto: um diálogo entre a teoria de Umberto Eco e a poética da leitura de Jorge Luis Borges

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A metamorfose seniana: poesia e crítica na obra de Jorge de Sena

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

De autor a personagem: Jorge Luis Borges na mira de romancistas latino-americanos

Pós-graduação em Letras - FCLAS

Construção da memória a partir dos lugares, instituições e documentos: um estudo do Centro de Documentação e Memória Pe. Antão Jorge do Santuário Nacional de Aparecida

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As representações do intelectual na correspondência entre Jorge de Sena e Vergílio Ferreira ― (1950‐1975)

The purpose of this article is to discuss the representations of intellectual in the epistolary production of Jorge de Sena (1919‐1978), more specifically in correspondence with Virgil Ferreira (1916‐1997), which occurred between the years 1950 to 1975. Some topics, such as the condition of intellectual dictatorship, the position of the writer and his relations with the aesthetics of Neo‐Realism and the condition of exile, are important topics that make up most of the concerns of both writers.

Duas poéticas da leitura: radição e invenção de precursores nos projetos literários de Jorge Luis Borges e Haroldo de Campos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Nutritional status and immune response in murine experimental Jorge Lobo's disease

There are no studies investigating the role of nutritional status and immunity associated with Jorge Lobo's disease. The objective of this study was to evaluate the effects of protein-calorie malnutrition on the immune response of BALB/c mice inoculated with Lacazia loboi. In this study,the animals were divided into four groups: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. The animals of groups G1 and G2 were submitted to malnutrition for 20 days and once installed the animals were inoculated intradermally into the footpad. After 4 months, they were euthanised for the isolation of peritoneal lavage cells and removal of the footpad. The production of IL-2, IL-4, IL-10, IL-12, IFN-γ, TNF-α, H2 O2 and nitric oxide (NO) was evaluated in the peritoneal lavage cells. The footpad was evaluated regarding the size of macroscopic lesions, number of fungi and viability index. The results showed that the infection did not exert great influence on the body weight of the mice and previous malnutrition was an unfavourable factor for viability index, number of fungi, macroscopic lesion size in the footpad and production of H2 O2 , NO, IL-12, IL-10 and IFN-γ, suggesting that malnutrition significantly altered fungal activity and peritoneal cells. The results suggest considerable interaction between nutrition and immunity in Jorge Lobo's disease.