Biocompatibility of a chlorhexidine local delivery system in a subcutaneous mouse model

Objective: This study aimed evaluating histologically and histomorphometrically the response of the conjunctive tissue face to the implant of chlorhexidine chips in the subcutaneous tissues of rats. Study Design: In this research 35 male rats Wistar were used to analyze the biocompatibility and the degradation process of chlorhexidine chip. In each animal, it was made 2 incisions for subcutaneous implantation of chlorhexidine chip (test group) and a polytetrafluorethylene membrane (control group). The morphological changes in subcutaneous implantations were assessed after 1, 3, 5, 7, 10, 14, 21 days. The data were submitted to Friedman nonparametric test to analyze the comparisons among observation periods and to allow the comparison among groups. Results: Differences were found in the analysis of the inflammatory response when comparing the tested materials (p values <= 0.05). In test group was observed hemorrhage, edema and intense inflammatory infiltrate predominantly neutrophilic around material. From 3-day and subsequent periods was verified granulation tissue externally at this infiltrate. From 10-day on was observed crescent area of degradation of chlorhexidine chip, associated with neutrophilic and macrophagic infiltrate, that maintained until 21-day. In the control group, moderate inflammatory infiltrate was observed initially, predominantly polymorphonuclear, edema and granulation tissue 3-day period. The inflammatory infiltrate was gradually replaced for granulation tissue, culminating in a fibrous capsule. Giant multinucleate cells situated at contact interface with the coating was examined since 3-day and persisted until 21-day. Conclusion: The chlorhexidine chip induces an intense acute inflammatory response at subcutaneous tissue of rats. Therefore, at conditions of this study was not biocompatible.

Absence motivated by illness: A non-concurrent prospective study of physical education teachers in the municipal education system of the city of Campinas, São Paulo, Brazil

The object of this investigation was to identify and analize aspects of the health status related to absenteism in physical education teachers in the municipal education system of the city of Campinas, Brazil, as related to the medical leave program. The non-concurrent prospective study was accomplished by means of a comparison with teachers who work only in the classroom, refering to a three year period. In the variables of greatest interest, the Pearson non-parametric chi-square (X2) statistical test was adopted. Calculations of relative risk and level of confidence were made using the Epi-info computer program. Significant differences were observed in the following diagnostic groups favoring the not exposed group: i) Supplementary Classification of factors that exercise influence over the health status and access to health services and ii) Digestive system illness; while the physical education teachers showed a significant difference in: i) diseases of the musculoskeletal and connective tissue system and ii) Injuries and poisoing. Possible explications for some of the adverse effects as well as the protective ones that were observed include physical activity as a way of life along with being a physical education teacher and on the other side, peculiar behavior of epidemiological descriptive characteristics, like sex and age, within the socio-economic context of the country. © Copyright Moreira Jr. Editora.

Efeitos da política de avaliação do PDE no sistema municipal de ensino

Pós-graduação em Educação - FFC

Uso do Google mapas como recurso didático para mapeamento do espaço local por crianças do ensino fundamental I da cidade de Ouro Fino/MG

Pós-graduação em Geografia - IGCE

Modulation of Maternal Immune System During Pregnancy in the Cow

There is a molecular crosstalk between the trophoblast and maternal immune cells of bovine endometrium. The uterine cells are able to secrete cytokine/chemokines to either induce a suppressive environment for establishment of the pregnancy or to recruit immune cells to the endometrium to fight infections. Despite morphological differences between women and cows, mechanisms for immune tolerance during pregnancy seem to be conserved. Mechanisms for uterine immunesuppression in the cow include: reduced expression of major histocompatability proteins by the trophoblast; recruitment of macrophages to the pregnant endometrium; and modulation of immune-related genes in response to the presence of the conceptus. Recently, an eGFP transgenic cloned embryo model developed by our group showed that there is modulation of foetal proteins expressed at the site of syncytium formation, suggesting that foetal cell can regulate not only by the secretion of specific factors such as interferon-tau, but also by regulating their own protein expression to avoid excessive maternal recognition by the local immune system. Furthermore, foetal DNA can be detected in the maternal circulation; this may reflect the occurrence of an invasion of trophoblast cells and/or their fragment beyond the uterine basement membrane in the cow. In fact, the newly description of exosome release by the trophoblast cell suggests that could be a new fashion of maternal-foetal communication at the placental barrier. Additionally, recent global transcriptome studies on bovine endometrium suggested that the immune system is aware, from an immunological point of view, of the presence of the foetus in the cow during early pregnancy.

Gestão da comunicação no arranjo produtivo local de brinquedos: Laranjal Paulista

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Provão: o impacto de sua implantação nos cursos superiores de Presidente Prudente - SP

Pós-graduação em Educação - FCT

Desafios para construção da autonomia dos sistemas municipais de ensino de Catanduva, Lins e Mauá

Pós-graduação em Educação - FFC

Políticas públicas em educação: contribuições para análise da oferta educacional no âmbito municipal (Araraquara/SP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Attitudes about inclusion by educators and physical educators: Effects of participation in an inclusive adapted physical education program

This study assessed the attitudes about the inclusion of students with disability by professionals in education and health, relative to their experience and training. We compared three groups: 20 teachers and trainees who worked in an adapted physical education program (GI); 75 professionals from the municipal education system of Rio Claro subdivided according to their experience-CGyes e CGno, respectively, with and without experience. We used the inventory adapted by Palla (2001) to assess participants' attitudes and self-concepts. Overall, individuals in the group that participated in the intervention maintained their tendency of being favorable toward inclusion. Teachers in regular school settings in the municipal school system of Rio Claro (Sao Paulo, Brazil), regardless of their experience with inclusive settings, remain mostly indecisive about the benefits of inclusion.

Microartefatos e processo de esculturação de vertentes: um estudo de caso do sítio arqueológico Lagoa do Camargo - Rio Claro-SP

This work discusses the analysis of microartifacts as a means to study the process of sculpturing of slopes actants of slopes actants of sculpturing in the archaeological site Lagoa do Camargo. Microartifacts have specific characteristics of transportation and deposition, that helps identifying shaping and sculpturing processes of slopes. The methogology used for analysis of microartifacts is based in Dunnel and Stein's theory (1989) that defines microartifacts as artifacts with reduced size - between 2mm and 0,25mm. According to the authors, an artifact is any object that presents attributes consequent of human activity, in other words, artificial. Also is used the protocol of Vance (1989), that proposed the analysis only the fraction between 0,5mm and 0,250 mm. For disclosure and preservation of archaeological patrimony in the city of Rio Claro, is intended development activities with schools of municipal education system, abour the subject Patrimonial Education, with the methodology adopted by the Institute for National Artistic and Historical Patrimony (IPHAN). Demonstrate and emphasize the importance of cultural patrimony within the local community provides the (re) cognition of these areas as conservation areas, which can be incorporated by this population as areas of collective interest

A Educação Não-Formal a partir dos relatórios da UNESCO

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Políticas públicas em educação ambiental no contexto da Conferência Nacional de Educação - CONAE 2010

n this paper I pose some questions that I systematized after taking part in a colloquium proposed by the National Conference on Education (CONAE 2010) to discuss the theme “Environmental Education and Curriculum Contextualization”. Regarding public environmental education policies, I try to indicate some perspectives that are both coherent with what Brazilian educators and environmentalists have been proposing and considered necessary for the consolidation of an Articulated National Education System. I present a synthesis of the environmental education proposals systematized in the CONAE Reference Document, which was designed as a guide to state and local conferences. I make an effort to carry out a preliminary analysis of both the process and the content of the public environmental education proposals systematized in the Essential Documents (Volumes I and II), Thematic Plenary Meeting Documents, and Final Document. Furthermore, I try to present a short synthesis of the prevailing tendencies of educational policies in Brazil in the last decades, pointing out the meaning and need of social activism for the construction of public policies for education, in general, and for environmental education, specifically.

Sala de recursos multifuncionais: um estudo de caso

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As parcerias entre prefeituras paulistas e o setor privado na política educacional: expressão de simbiose?

L'article présente les résultats finaux de l'enquête inter-institutionnelle qui a eu pour objet d'analyser la nature et les conséquences de partenariats conclus entre des secteurs privés et des gouvernements municipaux de la métropole de São Paulo pour le service de l'éducation à la maternelle et à l'enseignement élémentaire. La période a correspondu aux années 1996 à 2006, sachant que la perception d'une augmentation des responsabilités des municipalités pour l'offre éducationnelle, suite à la municipalisation de l'enseignement élémentaire, pourrait stimuler la sous-traitance de l'offre et la privatisation de l'éducation municipale. L'étude présente des tendances en relation avec trois modalités de partenariat: subvention publique pour l'offre de places en institutions privées de l'éducation élémentaire; acquisition de systèmes privés de l'enseignement et recours à des cabinets de conseil privés pour la gestion de l'éducation municipale. Les tendances perçues dans l'analyse indiquent que les actuelles relations entre les sphères publiques et privées dans le champ de l'éducation, suite à la décentralisation survenue dans le secteur, représentent un mouvement dans le sens de sa privatisation.