16 resultados para LBR 200

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The scheme named generator coordinate Hartree-Fock method (GCHF) is used to build (22s14p) and (33s22p16d9f) gaussian basis sets to S ((3)P) and Pt ((3)D) atoms, respectively. Theses basis sets are contracted to [13s10p] and [19s13p9d5f] through of Dunning's segmented contraction scheme and are enriched with d and g polarization functions, [13s10p1d] and [19s13p9d5flg]. Finally, the [19s13p9d5f1g] basis Set to Pt ((3)D) was supplemented with s and d diffuse functions, [20s13p10d5flg], and used in combination with [13s10p1d] to study the effects of adsorption of S ((3)D) atom on a pt ((3)D) atom belonged to infinite Pt (200) surface. Atom-atom overlap population, bond order, and infrared spectrum of [pt(_)S](2 -) were calculated properties and were carried out at Hartree-Fock-Roothaan level. The results indicate that the process of adsorption of S ((3)P) on pt ((3)D) in the infinite Pt (200) surface is mainly caused by a strong contribution of sigma between the 3p(z) orbital of S ((3)P) and the 6s orbital of pt ((3)D). (c) 2004 Elsevier B.V. All rights reserved.

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We investigated near-infrared-to-blue upconversion from thulium (Tm 3+) doped in tellurite glasses upon continuous wave excitation near 800 nm. We observed an enhancement of over two orders of magnitude of the upconverted emission at ∼480nm when neodymium (Nd 3+) ions were codoped with Tm 3+ ions. For comparison, using a Tm 3+:Nd 3+ codoped fluorozirconate glass as a reference material we observed a 40-fold enhancement of the blue emission. Analysis of the blue emission for samples with different doping levels of Nd 3+ ions showed that energy transfer between Nd 3+ and Tm 3+ is the mechanism responsible for the enhancement in upconversion. © 2002 American Institute of Physics. © 2002 American Institute of Physics.

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BACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the degree of sedation, intraocular pressure, and hemodynamic changes with premedication with low doses of oral clonidine, 100 μg and 200 μg, in outpatient cataract surgeries. METHODS: This is a randomized, double-blind, clinical study undertaken at the Universidade Federal de São Paulo with 60 patients of both genders, physical status ASA 1 and 2, ages 18 to 80 years. Patients were separated into three groups: placebo, clonidine 100 μg, and clonidine 200 μg. Intraocular pressure, heart rate, and blood pressure besides assessment of sedation were measured before and 90 minutes after the administration of clonidine. Sedation levels were classified according to the Ramsay sedation scale. RESULTS: Patients who received placebo and 100 μg of clonidine did not show reduction in heart rate, while a reduction in heart rate was observed in patients who received 200 μg of clonidine, and this difference was statistically significant. Patients who received 200 μg of clonidine also had a reduction in systolic and diastolic blood pressure (p < 0.05). One patient who received 200 μg of clonidine developed severe hypotension, with systolic pressure < 80 mmHg. Patients treated with clonidine had a reduction in intraocular pressure (p < 0.05). Ninety minutes after the oral administration of placebo and 100 μg and 200 μg of clonidine, 25%, 60%, and 80% of the patients respectively were classified as Ramsay 3 or 4. CONCLUSIONS: Clonidine 100 μg can be indicated as premedication for fasciectomies, being effective in sedation and reduction of intraocular pressure, without adverse effects on blood pressure and heart rate.

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Constant rate infusion (CRI) shows several advantages in balanced anesthesia, such as reduction of requirement for inhaled anesthetics and control of pain. The most commonly used drugs in these protocols are local anesthetics, dissociative, and opioids, which may be administered alone or in combinations. We evaluated the records of 200 dogs that underwent various surgical procedures with anesthetic or analgesic CRI in the perioperative period during 2011 and 2012 at the Veterinary Hospital of Franca University (Unifran), and identified possible complications during the transoperative period. Records evaluated included clinical state, laboratory tests, drugs used in premedication and induction, and CRI protocol. Acepromazine and morphine were the main drugs used in premedication. Propofol was used to induce anesthesia alone or in combination with other agents. We evaluated records of the 25 different CRI protocols. Fentanyl was the main drug employed in CRI, either alone or in combination. There were 128 episodes of anesthetic complications during CRI;the most common were hypotension, hypertension, and tachycardia, which occurred in 43 (32%), 35 (26.3%), and 19 (14.2%) dogs, respectively. Cardiac arrhythmia was reported in only 4 dogs. Signs of respiratory depression were present in dogs treated with 6 different CRI protocols. The consumption of isoflurane (vol %) reduced between 15.7% and 21.05% after 30minutes of the CRI in the fentanyl and fentanyl-lidocaine-ketamine CRI groups (p<0.05). In conclusion, CRI is a valid component of balanced anesthesia in dogs, safe, and has a low incidence of adverse effects. However, future studies are warranted to describe the results of the clinical use of CRI to better characterize and refine this technique.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em História - FCLAS

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Ligas que compreendem quantidades de metais expressas como porcentagens em peso, incluídas dentro dos seguintes intervalos: 8-20% de Al; 1-20% de Ag; 0-2% (de preferência 0,5-1%) de um metal minoritário (de preferência Co); e o resto até 1005 de Cu. As suas transformações martensíticas têm lugar a temperaturas superiores e aproximadamente 200°C, e próximas aos 400°C em alguns casos, sendo habituais as próximas aos 300°C. Possuem maior resistência à corrosão que as ligas convencionais. São úteis em novos campos de aplicação industrial como, por exemplo, no controle de temperatura em óleos de alto ponto de ebulição e em situações de grande desprendimento de calor por reações exotérmicas ou por grande roçamento.

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The goal of this project is the reproduction, through the simulation code based on the MCNPX (Monte Carlo N-Particle eXtended) v2.50 method, of the proton beam interaction with the material, since, in proton therapy, only the particle ionization and excitation are analyzed and the occurence of nuclear interactive inelastic process are not considered. This work will help the development of studies concerning the contribution to the total dosis of secondary particles generated by nuclear interaction in proton therapy. They are: alpha particles ( ), deuterium(2H), tritium (3H), neutron (n) and helium (3He). A MS20 tissue substitute phantom was used as the target and the energy of the proton beams was within an interest range of 100 to 200MeV. With the results obtained, it was possible to generate graphics which allows the analysis of the dosis deposition relation with and without nuclear interaction, the percentage of secondary particles deposited dosis, the radial dispersion of neutrons in the material, the secondary particles multiplicity, as well as the relation between the secondary particles spectrum with the próton generated spectrum

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In the treatment plans in conventional Proton therapy are considered only the elastic interactions of protons with electrons and/or nuclei, it means, mainly ionization and coulomb excitation processes. As the energy needed to reach the deep tumors should be of several hundred of MeVs, certainly the nuclear inelastic channels are open. Only some previous studies of the contribution of these processes in the full dose have been made towards targets composed of water. In this study will be presented the results of the simulation of the processes of interaction of beams of protons in the range of 100-200 MeV of energy with a cylindrical phantom composed by striated muscle (ICRU), emphasizing in the contribution to total dose due to the deposition of energy by secondary particles alpha (α), deuterium (2H), tritium (3H), neutron (n) and hélio3 (3He), originated by nuclear inelastic processes. The simulations were performed by using the method of Monte Carlo, via the computer code MCNPX v2.50 (Monte Carlo N-Particle eXtended). The results will be shown demonstrated through the graphics of the deposited dose with or without nuclear interaction, the percentual of dose deposited by secondary particles, the radial dispersion of neutrons, as well as the multiplicity of secondary particles

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In proton therapy, the deposition of secondary particles energy originated by nuclear inelastic process (n, 2H, 3H, 3He and α) has a contribution in the total dose that deserves to be discussed. In calculations of plans implemented for routine treatment, the paid dose is calculated whereas the proton loses energy by ionization and or coulomb excitement. The contribution of inelastic processes associated with nuclear reactions is not considered. There are only estimates for pure materials or simple composition (water, for example), because of the difficulty of processing targets consisting of different materials. For this project, we use the Monte Carlo method employing the code MCNPX v2.50 (Monte Carlo N-Particle eXtended) to present results of the contribution to the total dose of secondary particles. In this work, it was implemented a cylindrical phantom composed by cortical bone, for proton beams between 100 and 200 MeV. With the results obtained, it was possible to generate graphics to analyze: the dose deposition relation with and without nuclear interaction, the multiplicity and percentage of deposited dose for each secondary particle and a radial dispersion of neutrons in the material

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In the recent years, the use of proton beams in radiotherapy has been an outstanding progress (SMITH, 2006). Up to now, computed tomography (CT) is a prerequisite for treatment planning in this kind of therapy because it provides the electron density distribution required for calculation of dose and the interval of doses. However, the use of CT images for proton treatment planning ignores fundamental differences in physical interaction processes between photons and protons and is, therefore, potentially inaccurate (SADROZINSKI, 2004). Proton CT (pCT) can in principle directly measure the density distribution needed in a patient for the dose distribution (SCHULTE, et al, 2004). One important problem that should be solved is the implementation of image reconstruction algorithms. In this sense, it is necessary to know how the presence of materials with different density and composition interfere in the energy deposition by ionization and coulomb excitation, during its trajectory. The study was conducted in two stages, was used in both the program SRIM (The Stopping and Range of Ions in Matter) to perform simulations of the interaction of proton beams with pencil beam type. In the first step we used the energies in the range of 100-250 MeV (ZIEGLER, 1999). The targets were set to 50 mm in length for the beam of 100 MeV, due to its interaction with the target, and short-range, and 70 mm for 150, 200 and 250 MeV The target was composed of liquid water and a layer of 6 mm cortical bone (ICRP). It were made 9 simulations varying the position of the heterogeneity of 5 mm. In the second step the energy of 250 MeV was taken out from the simulations, due to its greater energy and less interaction. The targets were diminished to 50 mm thick to standardize the simulations. The layer of bone was divided into two equal parts and both were put in the ends of the target... (Complete abstract click electronic access below)

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The contribution of the total dose due to deposition of secondary energy particles caused by nuclear inelastic processes (n, 2H, 3H, 3He and  ) in proton therapy is an opened problem and in discussion. In the calculations of plans implemented for routine treatment, the paid dose is calculated whereas that the proton loses energy by ionization and or coulomb excitement. The contribution of inelastic processes associated with nuclear reactions is not considered, mainly due to the difficulty of processing targets consisting of various materials. In this sense, there are only estimates for pure materials or simple composition (water, for example).This work presents the results of simulations by the Monte Carlo method employing the code MCNPX v2.50 (Monte Carlo N-Particle eXtended) of the contribution to the total dose of secondary particles. The study was implemented in a cylindrical phantom composed by compact bone, for monochromatic beams of protons between 100 and 200 MeV with pencil beam form

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The present study aimed to determine the susceptibility of 17 Rhipicephalus (Boophilus) microplus populations, originating in the Southeast and Southern regions of Brazil, to different ivermectin concentrations (200, 500 and 630 mu g/kg), administered through subcutaneous or topical (pour-on) routes. R. (B.) microplus populations from the states of Minas Gerais (seven populations), Sao Paulo (seven populations) and Parana (three populations) were chosen for the tests. The selected cattle were allocated to treatment groups on day 0, and block formation was based on the arithmetic mean of female ticks (4.5-8.0 mm long) counted on three consecutive days (-3, -2 and -1). To evaluate the therapeutic and residual efficacies of these formulations, tick counts (females ranging from 4.5 to 8.0 mm long) were performed on days 3,7 and 14 post-treatment, and continued on a weekly basis thereafter until the end of each experiment. The results obtained throughout this study, utilizing field efficacy studies, allowed us to conclude that the resistance of R. (B.) microplus against 200 and 500 mu g/kg ivermectin is widely disseminated because all tick populations that had contact with these specific concentrations were diagnosed as resistant. However, it is possible to infer that R. (B.) microplus resistance against 630 mu g/kg ivermectin was also widespread, diagnosed at six of ten analyzed properties. Resistance of these ectoparasites to 630 mu g/kg ivermectin is most likely emerging in three other populations of R. (B.) microplus. Strategies of resistance management need to be quickly determined to keep the selection pressure at a minimum level in Brazil. (C) 2014 Elsevier B.V. All rights reserved.