Analysis of Factor VIII polymorphic markers as a means for carrier detection in Brazilian families with haemophilia A

Haemophilia A is an X-linked, recessively inherited bleeding disorder of varying severity, which results from the deficiency of procoagulant factor VIII f(8). Linkage diagnosis using polymorphic markers in the f8 gene is widely used to detect carriers. The objective of this study was to verify the informativeness of three polymorphic markers in the Brazilian population, to evaluate the usefulness of such markers in carrier detection procedures. Sixty-three unrelated healthy volunteers and 10 haemophilic families were studied. Two microsatellite repeats and one HindIII RFLP markers were used. Carrier and non-carrier status could be determined in 80% of females investigated. Intron 13 markers presented the highest heterozygosity rate (79%) followed by intron 22 (68%) and intron 19 (57%). When all three markers were used together, linkage analysis informativeness increased significantly. We conclude that these markers are suitable for carrier detection in the Brazilian population and we recommend their use in combination to maximize diagnostic efficiency.

Discurso e história: representações do feminino em Ana Bolena

The central theme of this work is the construction of the identity of the female gender in the light of discourse analysis. To achieve this goal we used three different media productions made during the twentieth and twenty-first century that address the same historical character: Anne Boleyn, the second wife of Henry VIII. From the research and analysis of images carefully selected to represent three different real moments of Anne Boleyn, it was possible to realize how the same scene may have different approaches and how such approaches are influenced not only by the author of the work, but also by a discursive game that coordinates what can or can't be said by a society. The study concludes that the discourse analysis, besides assisting in the understanding of life and speeches of the historical character in question, also provides subsidies to know the society not only at the time that Anne Boleyn lived, but also at the time when the media productions studied here were performed

Metabolite fingerprint of "capim dourado" (Syngonanthus nitens), a basis of Brazilian handcrafts

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Conflitos proféticos: a posição da profecia no campo religioso judaíta do século VIII a.C

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Trends in Brazilian academic production in the History of Mathematics Education: directions from EBRAPEM

The number of papers on History of Mathematics Education presented at EBRAPEM (Brazilian Meeting of Graduate Students in Mathematics Education) has increased significantly between 2003 and 2008. This article presents a study with the aim of identifying themes, periods in focus, and sources and theoretical and methodological references used by the authors of the papers on History of Mathematics Education published in the proceedings of VII, VIII, IX, X, XI and XII EBRAPEM. The study indicates that the approach of ongoing research in History of Mathematics Education in Brazil has been similar to the approach of research in History of Education in general. However, the institutional separation between these two areas of investigation is noted as a factor rendering communication between both groups of researchers difficult.

Memórias Obscuras: o terror nos contos de Henry Evaristo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Cationização de amidos de tuberosas tropicais para fabricação de papéis

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A solidariedade e a cooperação como estratégias para um trabalho eficaz no ambiente escolar

Pós-graduação em Educação Matemática - IGCE

Ocorrência de inibidores de fator de coagulação em pacientes hemofílicos atendidos no hemocentro regional de Maringá-PR

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

O engenheiro Antônio Soares Romêo e a modernização urbana de Ribeirão Preto nos tempos do café (1913-1923)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A expressão da cultura nobiliárquica nos livros de viagens medievais

Pós-graduação em História - FCHS

Contaminação do lençol freático e cultivo de alface sob irrigação com água residuária

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização dos ambientes deposicionais na bacia do Ribeirão Entupido, complexo alcalino do Passa Quatro, estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Suplementação de ração de codornas com vitaminas A, D e E sobre o desempenho e qualidade dos ovos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo fitossociológico e interferência das plantas daninhas na nutrição e produtividade do quiabeiro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)