Biomolecular information, brain activity and cognitive functions

Molecular neurobiology has provided an explanation of mechanisms supporting mental functions as learning, memory, emotion and consciousness. However, an explanatory gap remains between two levels of description: molecular mechanisms determining cellular and tissue functions, and cognitive functions. In this paper we review molecular and cellular mechanisms that determine brain activity, and then hypothetize about their relation with cognition and consciousness. The brain is conceived of as a dynamic system that exchanges information with the whole body and the environment. Three explanatory hypotheses are presented, stating that: a) brain tissue function is coordinated by macromolecules controlling ion movements, b) structured (amplitude, frequency and phase-modulated) local field potentials generated by organized ionic movement embody cognitive information patterns, and c) conscious episodes are constructed by a large-scale mechanism that uses oscillatory synchrony to integrate local field patterns. © by São Paulo State University.

Efeitos do exercício físico multimodal nas concentrações plasmáticas de biomarcadores, funções cognitivas e funcionalidade em pacientes com doença de Alzheimer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Contribuições da teoria histórico-cultural para o processo de avaliação psicoeducacional

Cet article a comme objectif présenter la contribution de la Psychologie Historique-Culturelle pour l'analyse critique de l'évaluation psychoéducationnel traditionnel et postuler les fondements pour la nouvelle modalité évaluative. Cette proposition se justifie à cause de l'actuelle révitalisation de l'usage des testes padronisés pour la mensuration des fonctions psychologiques, dues à la vulgarisation de la neuropsychologie. Historiquement les testes padronisés servent comme instrument pour attester cientifiquement l'idéologie de l'égalité entre les hommes dans la societé capitaliste que se maintient à travers de l'expropriation et de l'exclusion. En outre, il existe une forte tendence à attendre que les résultats expliquent l'intelligence comme inée ou considèrent les prédispositions héréditaires pour apprendre, ce qu'on oppose à la comprehénsion que les fonctions mentales sont formées dans le proccès de développement historique-social à travers l'appropriation de la culture humaine. Il est nécessaire donc une évaluation qui considère les médiations sociales (des instruments et des signes) comme constituants des fonctions psychologiques encourageant le développement de tous les individus et la non légitimation de l'exclusion sociale.

Taenia solium DNA is present in the cerebrospinal fluid of neurocysticercosis patients and can be used for diagnosis

Neurocysticercosis is the most frequent parasitic infection of the CNS and the main cause of acquired epilepsy worldwide. Seizures are the most common symptoms of the disease, together with headache, involuntary movements, psychosis and a global mental deterioration. Absolute diagnostic criteria include the identification of cysticerci, with scolex, in the brain by MRI imaging. We demonstrate here, for the first time, that T. solium DNA is present in the cerebrospinal fluid of patients. The PCR amplification of the parasite DNA in the CSF enabled the correct identification of 29/30 cases (96.7 %). The PCR diagnosis of parasite DNA in the CSF may be a strong support for the diagnosis of neurocysticercosis.

Controle aproximado para sistemas não-lineares de equações diferenciais ordinárias

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Lineamentos da atividade mediadora em Vygotski

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fundamentos teóricos da atividade de estudo como modelo didático para o ensino das disciplinas científicas

Pós-graduação em Educação para a Ciência - FC

A reorganização do espaço da sala de educação infantil: uma experiência concreta à luz da teoria histórico-cultural

Pós-graduação em Educação - FFC

Dificuldades referidas por pessoas com deficiência física em um inquérito de saúde no município de Botucatu

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O papel da professora no desenvolvimento humano da criança pré-escolar sob o enfoque da teoria histórico-cultural

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Desenvolvimento da memória em crianças pré-escolares por meio de atividades literárias: contribuições da Teoria Histórico-Cultural

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Effects of square-stepping exercise on cognitive functions of older people

Aim: Cognitive functions can decline with age, and interventions focusing on stimulating them may have positive results. Previous studies have shown that square-stepping exercise (SSE) has a good influence on balance, but this exercise also seems to promote cognitive stimulation. Therefore, the purpose of the present study was to analyse the effect of 16 weeks of SSE on cognitive functions in non-demented community-dwelling older people. Methods: This was a longitudinal, non-randomized study. Forty-one older adults (60 years and older) were recruited, and 21 participated in the SSE group (practised only SSE sequences) and 20 were in the control group (continued with their activities of daily living). Both groups were evaluated using the Mini-Mental State Examination, the Digit Span test, the Toulouse-Pierón Attention Test and the Modified Card Sorting Test. Results: The SSE group showed a significant improvement in global cognitive status, concentrated attention and mental flexibility after 16 weeks of the SSE intervention. Conclusion: Evidence shows that SSE is a physical activity that positively influences cognitive functions in non-demented older people. © 2013 Japanese Psychogeriatric Society.

A controlled clinical trial on the effects of motor intervention on balance and cognition in institutionalized elderly patients with dementia

Purpose: To analyse the effects of two interventions on the cognition and balance of institutionalized elderly people with mixed dementia.Methods: Fifty-four participants were allocated into three groups. Group 1 was assisted by an interdisciplinary programme comprising physiotherapy, occupational therapy and physical education. A physiotherapist alone carried out the intervention in group 2. Group 3 was considered as control. Assessors were blinded to guarantee the absence of bias. Cognitive functions were analysed with the Mini-Mental State Examination and the Brief Cognitive Screening Battery. Balance was assessed with the Berg Balance Scale and the Timed Get-Up-and-Go Test. Multiple analysis of variance (MANOVA) was used to test possible main effects of the interventions.Results: The results showed benefits on the balance of subjects in both groups 1 (F=3.9, P < 0.05) and 2 (F= 3.1, P < 0.05), compared with group 3. MANOVA did not indicate benefits on the cognitive functions between groups 1 and 3 (F= 1.1, P > 0.05) and groups 2 and 3 (F= 1.6, P > 0.05). However, univariate analysis indicated some benefits of the interdisciplinary intervention on two specific domains measured by the Brief Cognitive Screening Battery (F=26.5, P < 0.05; F= 4.4, P < 0.05).Conclusion: Six months of multidisciplinary or physiotherapeutic intervention were able to improve a person's balance. Although global cognition did not improve through treatment, when the intervention was carried out on a multidisciplinary basis we observed an attenuation in the decline of global cognition on two specific cognitive domains. Exercises applied in different contexts may have positive outcomes for people with dementia.

A common Tabu search algorithm for the global optimization of engineering problems

A novel common Tabu algorithm for global optimizations of engineering problems is presented. The robustness and efficiency of the presented method are evaluated by using standard mathematical functions and hy solving a practical engineering problem. The numerical results show that the proposed method is (i) superior to the conventional Tabu search algorithm in robustness, and (ii) superior to the simulated annealing algorithm in efficiency. (C) 2001 Elsevier B.V. B.V. All rights reserved.

Relationship between global structural parameters and Enzyme Commission hierarchy: Implications for function prediction

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)