Abuso sexual infantil e incesto: a ética da escuta na clínica de Françoise Dolto

This paper will discuss some aspects of the problem of child sexual abuse, specifically incest, drawing on psychoanalysis and in particular the psychoanalytic proposed by Françoise Dolto allowing their concepts of castration simboligênica, symbolic function, image and body language unconsciously take incest as the object of study to propose a psychoanalytic clinic devoted to listening to the subject, going beyond the legal concerns of policies on reporting and complaints, but not meddle in them, reflecting on the role of the psychologist and psychoanalyst in the clinic for children of sexual abuse.

Cigarette smoking and high-risk HPV DNA as predisposing factors for high-grade cervical intraepithelial neoplasia (CIN) in young Brazilian women

Background. This cross-sectional study was designed to evaluate the role of cigarette smoking and high-risk HPV types as risk factors of CIN 2 and 3 in young, sexually active Brazilian women. Materials and method. A series of 100 consecutive women with abnormal Pap smears were recruited, subjected to colposcopy, punch biopsy, and questionnaire for their social, sexual and reproductive factors. Of these, 77 women between 20 and 35 years of age (median 26.5 years) with biopsy-confirmed CIN 1 or CIN 2 and 3, were enrolled in this study. Representative samples from the exocervix and endocervix were obtained for HPV testing with the Hybrid Capture HPV-DNA assay, including the probes for the oncogenic HPV types (16, 18, 31, 33, 35, 45, 51, 52 and 56). Results. The overall rate of CIN 2 and 3 was 23/77 (29.8%). The women with CIN 1, 2 and 3 did not differ from each other with regard to their age, race, schooling, marital status, life-time number of sexual partners, age at first intercourse, use of oral contraceptives, or parity. However, current cigarette smoking was strongly associated with CIN 2 and 3 (p < 0,001), and among smokers, the risk of high-grade CIN increased in parallel with the time of exposure (years of smoking) p = 0.07), HPV-DNA of the oncogenic types was detected in 43 (56%) women, the risk of being HPV DNA-positive was significantly higher in CIN 2 and 3 as compared with CIN 1 (p = 0.037). Importantly, the prevalence of high-risk HPV types was significantly higher in cigarette smokers than in non-smokers (p = 0.046). Conclusions. The results indicate that the severity of CIN lesions was clearly related to two fundamental risk factors: 1) high-risk HPV types, and 2) current cigarette smoking. These two risk factors were closely interrelated in that the high-risk HPV types were significantly more frequent in current smokers than in non-smokers, suggesting the possibility of a synergistic action between these two risk factors in cervical carcinogenesis.

Chitosan nanoparticles for non-viral gene therapy

The cationic polysaccharide chitosan has been widely used for non-viral transfection in vitro and in vivo and has many advantages over other polycations. Chitosan is biocompatible and biodegradable and protects DNA against DNase degradation. However following administration the ChitosanDNA polyplexes must overcome a series of barriers before DNA is delivered to the cell nucleus. This paper describes the most important parameters involved in the chitosan-DNA interaction and their effects of on the condensation, shape, size and protection of DNA. Strategies developed for chitosanDNA polyplexes to avoid non-specific interaction with blood components and to overcome intracellular obstacles as the crossing of die cell membrane, endosomal escape and nuclear import are presented. © 2006 American Chemical Society.

Clinical and molecular phenotype of Aicardi-Goutières syndrome

Aicardi-Goutières syndrome (AGS) is a genetic encephalopathy whose clinical features mimic those of acquired in utero viral infection. AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3′→5′ exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex. To define the molecular spectrum of AGS, we performed mutation screening in patients, from 127 pedigrees, with a clinical diagnosis of the disease. Biallelic mutations in TREX1, RNASEH2A, RNASEH2B, and RNASEH2C were observed in 31, 3, 47, and 18 families, respectively. In five families, we identified an RNASEH2A or RNASEH2B mutation on one allele only. In one child, the disease occurred because of a de novo heterozygous TREX1 mutation. In 22 families, no mutations were found. Null mutations were common in TREX1, although a specific missense mutation was observed frequently in patients from northern Europe. Almost all mutations in RNASEH2A, RNASEH2B, and RNASEH2C were missense. We identified an RNASEH2C founder mutation in 13 Pakistani families. We also collected clinical data from 123 mutation-positive patients. Two clinical presentations could be delineated: an early-onset neonatal form, highly reminiscent of congenital infection seen particularly with TREX1 mutations, and a later-onset presentation, sometimes occurring after several months of normal development and occasionally associated with remarkably preserved neurological function, most frequently due to RNASEH2B mutations. Mortality was correlated with genotype; 34.3% of patients with TREX1, RNASEH2A, and RNASEH2C mutations versus 8.0% RNASEH2B mutation-positive patients were known to have died (P = .001). Our analysis defines the phenotypic spectrum of AGS and suggests a coherent mutation-screening strategy in this heterogeneous disorder. Additionally, our data indicate that at least one further AGS-causing gene remains to be identified. © 2007 by The American Society of Human Genetics. All rights reserved.

Caracterização de cultivares de uvas para vinho sobre porta-enxertos, em Jundiaí-SP

Pós-graduação em Agronomia (Horticultura) - FCA

Memória, História e Patrimônio: perspectivas comtemporâneas da pesquisa histórica

It should be noted that the studies for some time been considering the historical importance of objects and space as components of memory - or “places of memory” in the words of Pierre Nora. The memory would thus be defi ned as an imaginary dimension of society, a mental universe that acquires and social substance that creates the individual with a “social whole” in an open line of work by M. Halbwachs. And this notion of memory allows us to grasp the question sheet. This cult of memory had its place also rise through the delimitation of national heritage - as Françoise Choay, since the establishment of categories of historical monuments in France in 1837. The discussion on equity has progressed in recent decades, as it is conceived as objects, spaces, knowledge and events become “intangible heritage” because it has reference value to the community. It is considered that the references are the property constituting the objects of memory formation, forms of work-life past or present. Anyway, heritage presents itself as the embodiment of a discourse about the past.

Atendimento psicoterapêutico para crianças vítimas de violência sexual: projeto Sarauzinho

This experiment report refers to the project named “Sarauzinho”, which is linked to the extension “Workshops of Psychoanalysis and Artistics Gatherings” project. “Sarauzinho” was a partnership between UNESP and CREAS, created with the aim to assist children victims of sexual violence though a playful and artistic method and to implement a psychoanalytic listening of demands that appeared during the working group implementation. At the same time, the parents/responsible person who took the children to the meetings also received psychotherapeutic service at the waiting room, in an operative group format with psychoanalytic listening. The project has happened in 11 sessions (once a week, two hours each), with 4 kids and 4 caregivers participating. The service for the kids was organized in workshop models (open and free) and in little gatherings, with preprogrammed contents (playful and artistic). The initiative was inspired by the “Green houses”, a creation of the French psychoanalyst Françoise Dolto, and by the Museum “Imagens do Inconsciente do Centro Psiquiátrico Pedro II”, in Nise da Silveira, Rio de Janeiro city. This university extension activity has enabled the students to access some of the children’s traumas, as well as to obtain a better understanding of an infantile group psychotherapeutic service, with psychoanalytic listening. Besides, it has provided a playful and artistic environment to listen to the children and enable them to create new meanings of their traumas. For the adult participants, the meetings were moments to talk about their anxieties and to receive new guidance and instructions about their children’s education, especially about sexuality. The results, either related to the children’s meeting, as to the adult’s meeting, were favorable to the continuity of the project.

A inserção social do banco dos cocais no município de São João do Arraial - PI

Pós-graduação em Geografia - IGCE