Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients

The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being recognized in Brazilian and French patients, respectively. The GPGR (P) motif was predominant in French but not in Brazilian patients (53.5% vs 31.0%), whereas the GWGR (W) motif was frequent in Brazilian patients (23.0%) and absent in French patients. Three tip motif groups were considered: P, W, and non-P non-W groups. The distribution of HIV-1 isolates into the three groups was significantly different between isolates from Botucatu and from Montpellier (P < 0.001). A higher proportion of CXCR4-using HIV-1 (X4 variants) was observed in the non-P non-W group as compared with the P group (37.5% vs 19.1%), and no X4 variant was identified in the W group (P < 0.001). The higher proportion of X4 variants in the non-P non-W group was essentially observed among the patients from Montpellier, who have been infected with HIV-1 for a longer period of time than those from Botucatu. Among patients from Montpellier, CD4+ cell counts were lower in patients belonging to the non-P non-W group than in those belonging to the P group (24 cells/µL vs 197 cells/µL; P = 0.005). Taken together, the results suggest that variability of the V3 loop tip motif may be related to HIV-1 coreceptor usage and to disease progression. However, as analyzed by a bioinformatic method, the substitution of the V3 loop tip motif of the subtype B consensus sequence with the different tip motifs identified in the present study was not sufficient to induce a change in HIV-1 coreceptor usage.

A realidade-ficção do discurso televisivo

Pós-graduação em Estudos Linguísticos - IBILCE

Docweb: análise do documentário on-line HayMotivo.com

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Benjamin torto na vida: o personagem gauche no romance de Chico Buarque

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Presença do naturalismo francês no romance epistolar O marido da adúltera, de Lúcio de Mendonça

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Indivisíveis, intangíveis, impossíveis: mundos ficcionais em I nostri antenati, de Italo Calvino

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Folhetins do século XIX: uma prática de leitura apaixonada

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Polymorphic Sites at the 3 ' Untranslated Region of the HLA-G Gene Are Associated with Differential hla-g Soluble Levels in the Brazilian and French Population

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aboutness in Fiction: Methodological Perspectives for Knowledge Organization

The subject analysis of narrative texts of fiction is complex; the methodological model of identification of concepts as elaborated for scientific texts is not applicable to fiction. It is proposed here that theoretical and methodological use of the Generative Trajectory of Meaning postulated by Greimas may contribute to the identification of aboutness in narrative texts of fiction.

L'Arrière-pays de Yves Bonnefoy, viagem e escrita de si

This essay attempts to approach the book L’Arrière-pays by Yves Bonnefoy from two central ideas: the notion of travel and autobiographical writing. They belong to the poet’s project, according to which, since L’Improbable published in 1959, and with reference to Baudelaire, “poetry and travel are of the same substance”. Invited by Albert Skira to participate in the collection  Sentiers de la création, Yves Bonnefoy produces in  L’Arrière-pays  a long essay in which he combines art criticism, philosophical reflection and personal narrative. With narrative projects abandoned or transformed into poems, as in the case of L’Ordalie, incorporated into the book Du Mouvement et de l’immobilité de Douve (1953), Yves Bonnefoy in L’Arrière-pays establishes a first path to reconsider the association between narrative and fiction and, for that reason, is the central text of what the poet called his «conversion».

Prostituição e morte em Maggie: a girl of the streets: uma leitura feminista sobre a Slum fiction norte-americana de Stephen Crane

Pós-graduação em Letras - FCLAS

O narrador de Helena de Machado de Assis: ethos modernizador em matéria literária acanhada

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)