Participación politica y derechos humanos, una questión de genero en la escuela

Este texto trae consideraciones respecto de una investigación que se está desarrollando en escuelas públicas Marília (SP). El objetivo es observar cómo la democracia es experimentada en la existencia cotidiana de vida escolar y cómo los derechos humanos y la cuestión de género aparecen en las relaciones sociales y en su proyecto político-pedagógico. Se supone que la educación democrática sólo se concretará en la escuela si dos dimensiones de la educación escolar son trabajados: la escuela como locus de participación democrática y los estudios basados en la ética y los derechos humanos, que no podrán descartar la cuestión del género. Hemos elaborado que la educación para la ciudadanía no puede descartar la ciudadanía política, además de los derechos humanos y cuestiones de género, de lo contrario, no niños y niñas sensibles a ellos.

Efeito das baixas concentrações de agentes antineoplásicos sobre linfócitos humanos de sangue periférico

Our previous studies have shown that low concentrations (noncytotoxics) of antineoplastic agents modulate positively the dendritic cells, favoring their in vitro maturation and improving their antigen presenting function. The effects on colorectal cancer cells (HCT-116) were also investigated and we have observed an increased immunogenicity and susceptibility to cytotoxic T cells. Thereby, this study aimed to investigate the effect of 5-fluorouracil (5-FU) an azacitidine (AZA), in minimum effective and noncytotoxic concentrations on lymphocytes of healthy donors. In this study we have analyzed the cytotoxic effect of drugs at these concentrations as well as the proliferative ability of lymphocytes. In vitro production of IL-10 and IFN-γ has been also evaluated. We have observed that low concentrations of those chemotherapeutic agents are not cytotoxic for lymphocytes. However, the minimum effective concentrations (5-FU: 0,410±0,088 e AZA: 0,757±0,233; p<0, 05) have reduced the cell number. Proliferative activity of allogeneic lymphocytes in a mixed reaction (MLR) was not affected by the treatment. The cytokine production was not affected by the treatments, either. In conclusion, low concentrations of 5-FU and AZA has no deleterious effects on human peripheral blood lymphocytes and seems to be safe for combinatory administration with DC vaccines