The Origin of Nonmonotonic Complex Behavior and the Effects of Nonnative Interactions on the Diffusive Properties of Protein Folding

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Frustration and hydrophobicity interplay in protein folding and protein evolution

A lattice model is used to study mutations and compacting effects on protein folding rates and folding temperature. In the context of protein evolution, we address the question regarding the best scenario for a polypeptide chain to fold: either a fast nonspecific collapse followed by a slow rearrangement to form the native structure or a specific collapse from the unfolded state with the simultaneous formation of the native state. This question is investigated for optimized sequences, whose native state has no frustrated contacts between monomers, and also for mutated sequences, whose native state has some degree of frustration. It is found that the best scenario for folding may depend on the amount of frustration of the native structure. The implication of this result on protein evolution is discussed. (c) 2006 American Institute of Physics.

Multiferroicity in an organic charge-transfer salt that is suggestive of electric-dipole-driven magnetism

Multiferroics, showing simultaneous ordering of electrical and magnetic degrees of freedom, are remarkable materials as seen from both the academic and technological points of view. A prominent mechanism of multiferroicity is the spin-driven ferroelectricity, often found in frustrated antiferromagnets with helical spin order. There, as for conventional ferroelectrics, the electrical dipoles arise from an off-centre displacement of ions. However, recently a different mechanism, namely purely electronic ferroelectricity, where charge order breaks inversion symmetry, has attracted considerable interest. Here we provide evidence for ferroelectricity, accompanied by antiferromagnetic spin order, in a two-dimensional organic charge-transfer salt, thus representing a new class of multiferroics. We propose a charge-order-driven mechanism leading to electronic ferroelectricity in this material. Quite unexpectedly for electronic ferroelectrics, dipolar and spin order arise nearly simultaneously. This can be ascribed to the loss of spin frustration induced by the ferroelectric ordering. Hence, here the spin order is driven by the ferroelectricity, in marked contrast to the spin-driven ferroelectricity in helical magnets. © 2012 Macmillan Publishers Limited. All rights reserved.

Thickness dependence of structure and piezoelectric properties at nanoscale of polycrystalline PZT thin films

Lead zirconate titanate Pb(Zr 0.50Ti 0.50)O 3 (PZT) thin films were deposited by a polymeric chemical method on Pt(111)/Ti/SiO2/Si substrates to understand the mechanisms of phase transformations and the effect of film thickness on the structure, dielectric and piezoelectric properties in these films. PZT films pyrolyzed at temperatures higher than 350 °C present a coexistence of pyrochlore and perovskite phases, while only perovskite phase grows in films pyrolyzed at temperatures lower than 300 °C. For pyrochlore-free PZT thin films, a small (100) orientation tendency near the film-substrate interface was observed. Finally, we demonstrate the existence of a self-polarization effect in the studied PZT thin films. Results suggest that Schottky barriers and/or mechanical coupling near the filmsubstrate interface are not primarily responsible for the observed self-polarization effect in our films. © 2012 IEEE.

Entre o êxito e a frustação com a operacionalização da SAE: recursos humanos como componente determinante para a visibilidade do enfermeiro no processo de trabalho

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Estudo do efeito da adição de frustração no enovelamento de proteínas utilizando modelos baseados em estruturas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A gente é nascido e criado aqui.: memória e territorialidade no bairro Boa Vista, Bragança Paulista - SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo do coeficiente de difusão no enovelamento de proteína

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Evasão e evadidos: o discurso dos ex-alunos sobre evasão escolar nos cursos de licenciatura

Pós-graduação em Educação - FFC

Compreendendo o impacto das diretrizes propostas pela Política Nacional de Práticas Integrativas e complementares em serviços de homeopatia do Sistema Único de Saúde

Pós-graduação em Saúde Coletiva - FMB

Estudo da interação não-nativa no enovelamento de proteínas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Relações exteriores da Guiné-Bissau: um estudo das relações bilaterais Guiné-Bissau/Brasil (1974-2014)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Poe, Baudelaire, Huysmans: dândis e malditos

Poe, Baudelaire and Huysmans, voices that bewilder readers due to their literary iconoclastic impulse, knew how to bother society and tradition becoming archetypes of the poèt maudit. Eccentrics, these poets, living exiled to the margins of the frustrated bourgeois society with its moral rules, wish for something beyond world then was offering; so, they turn for the mysterious regions of the obscure, of the sordidness and of the Satanic, finally becoming the poets of the abyss. At the same time maudits and aesthetes, they wish to be sublime and consider the dandyism like the last ray of light of the decadence: it is what this article intends to discuss.

Aspetos da vida universitária e a síndrome de burnout

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Via Láctea: História (parnasiana) de uma paixão

Poesias (1888), Olavo Bilac’s first book, contains Via Láctea, a collection of sonnets of love that, in frank rupture with the romantic sentimentalism, is characterized by neoclassical moderation and contention. Universalizing treatment of the themes results in concealment of the particular circumstances in which the poems were composed. It is intended in these few pages to evidence the links between these texts and known episodes of the courtship of the poet and Amélia de Oliveira, the sister of Alberto de Oliveira, with the goal of providing an understanding of Via Láctea as a “love diary” in which the painful stations of a frustrated passion were registered.