A genômica funcional no âmbito da produção animal: estado da arte e perspectivas

Os últimos vinte anos caracterizaram-se pela proliferação de tecnologias que tornaram possível decifrar o genoma das espécies, localizar e identificar particularidades na sua seqüência, elucidar as suas funções dentro dos sistemas biológicos e, sobretudo, começar a entender os mecanismos que controlam as interações entre os genótipos e os estímulos ambientais, que são responsáveis pela diversidade fenotípica. Estes estudos sobre as bases moleculares da variabilidade fenotípica abriram uma nova abordagem científica, caracterizada pela multiplicidade das questões envolvidas, que resultou no surgimento de novas áreas de pesquisa, cujos conhecimentos estão sendo aplicados em diversos campos da biologia, inclusive na zootecnia. Tendo em vista o grande impacto que tais conhecimentos estão tendo sobre a compreensão dos fenômenos biológicos, parece ser oportuno fazer uma avaliação das potencialidades de aplicação das abordagens de Genômica Funcional em pesquisas de nutrição e alimentação de ruminantes. Nesse contexto, este artigo está focado na descrição das principais ferramentas genômicas disponíveis e na discussão sobre a viabilidade de se utilizar as informações por elas geradas em benefício da produção animal.

Do diagnóstico à conservação da biodiversidade: o estado da arte do programa BIOTA/FAPESP

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Solução cardioplégica polarizante: estado da arte

A exegese do termo cardioplegia remete aos significados de lesão, golpe, ataque ou ferimento, bem diferente, portanto, do sentido em que o termo é empregado na maior parte dos centros de cirurgia cardíaca do Brasil e do mundo, ou seja, como correspondendo à proteção miocárdica. Daí a melhor denominação de solução cardioplégica, para caracterizar as soluções empregadas com finalidade de promover a parada cardíaca controlada do coração. A parada cardíaca induzida por solução cardioplégica pode acontecer por hiperpolarização, despolarização ou com bloqueadores da bomba de cálcio. No presente trabalho, discorreremos sobre os principais agentes que promovem a parada cardíaca por hiperpolarização da membrana miocárdica. Com a solução hiperpolarizante, o coração pára no período diastólico, havendo uma redução ainda maior no seu gasto energético, o que propicia melhores condições ao coração quando este reinicia sua contração ao final do procedimento cirúrgico.

Varistores à base de SnO2: estado da arte e perspectivas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estado da arte da obtenção de crédito de carbono via adoção de veículo elétrico

This paper aims to highlight the state of the art of obtaining carbon credits through the use of electric vehicles. This is one of the solutions to significantly reduce the emission of GHG (Greenhouse Gas) emissions in the case of CO 2, NOx, SOx, and CH 4 (thermochemical reactions arising from the combustion of gasoline with ethanol) in motor vehicles. For this quantitative study was done based on the survey of bibliographic data available and the development of basic calculations considering the car fleet of the Country of Brazil and the CO 2 emissions generated by the same. Thus explaining the considerable gain in air quality and reduction of vectors of greenhouse gases in the case of replacing the current fleet of vehicles combustion of hydrocarbon aliphatic chain, for an eco-efficient fleet consists of electric vehicles and/or hybrids.

O estado da arte da ecologia da restauração e sua relação com a restauração de ecossistemas florestais no bioma Mata Atlântica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Metabolômica, uma abordagem otimizada para exploração da biodiversidade brasileira: estado da arte, perspectivas e desafios

Brazilian biodiversity is a colossal source of secondary metabolites with remarkable structural features, which are valuable in further biodiscovery studies. In order to fully understand the relations and interactions of a living system with its surroundings, efforts in natural product chemistry are directed toward the challenge of detecting and identifying all the molecular components present in complex samples. It is plausible that this endeavor was born out of recent technological sophistication in secondary metabolite identification with sensitive spectroscopic instruments (MS and NMR) and higher resolving power of chromatographic systems, which allow a decrease in the amount of required sample and time to acquire data. Nevertheless, the escalation of data acquired in these analyses must be sorted with statistical and multi-way tools in order to select key information. Chromatography is also of paramount importance, more so when selected compounds need to be isolated for further investigation. However, in the course of pursuing a greener environment, new policies, with an aim to decrease the use of energy and solvents, are being developed and incorporated into analytical methods. Metabolomics could be an effective tool to answer questions on how living organisms in our huge biodiversity work and interact with their surroundings while also being strategic to the development of high value bio-derived products, such as phytotherapeutics and nutraceuticals. The incorporation of proper phytotherapeutics in the so-called Brazilian Unified Health System is considered an important factor for the urgent improvement and expansion of the Brazilian national health system. Furthermore, this approach could have a positive impact on the international interest toward scientific research developed in Brazil as well as the development of high value bio-derived products, which appear as an interesting economic opportunity in national and global markets. Thus, this study attempts to highlight the recent advances in analytical tools used in detection of secondary metabolites, which can be useful as bioproducts. It also emphasizes the potential avenues to be explored in Brazilian biodiversity, known for its rich chemical diversity.

Escolarização formal e dimensões curriculares para alunos com autismo: o estado da arte da produção acadêmica brasileira

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A produção em sexualidade, gênero e educação sexual na ANPED: estudo analítico-descritivo a partir do estado da arte como opção metodológica

Pós-graduação em Educação Escolar - FCLAR

Estado da arte sobre sexualidade e educação sexual: estudo analítico-descritivo de teses e dissertações produzidas na Universidade Estadual Paulista

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Neuróbica, ginástica para o cérebro: levantamento do atual estado da arte deste tema

This paper presents a brief review of theoretical studies on the stimulation and brain development. We also addressed questions about its plasticity, its influence on learning and behavior of the individual in interaction with the environment. Studies clearly show that the brain does not go into decline as we age. In this sense, a new discovery in neuroscience has revealed that the brain maintains the ability to grow and change the pattern of its connections to death. Findings such as these form the basis of neurobics. Demonstrating the importance of a relevant application of appropriate stimuli to change the morphology and function of neurons, the technique can be applied in different ways, ie, clinical, behavioral and neurological. Furthermore it can be applied during all phases of human development

O estado da arte das vocalizações de anfíbios anuros da Mata Atlântica

The vocals are the most conspicuous means of communication between frogs and can express evolutionary relationships among species. Call descriptions of frogs, in general, not standard acoustic parameters which are greatly diversified and usually restricted to comparisons between closely related taxa. The Atlantic Forest is considered one of the biodiversity hotspots of the world, however, it appears that the number of species to be known is still very large. To anurans from this Brazilian Domain, vocalizations are complex and can vary intra and interpopulations. Thus, we presented a quantitative and qualitative analysis of the work descriptions of anuran advertisement call from the Atlantic Forest, available in the literature so far. The frog species from this Domain and their descriptions of the advertisement call have been raised in the literature, organized into families and threat category IUCN Red List Threatened Species. The analysis of the descriptions were made based on the presence of preset parameters. It was observed that the species which the advertisement call is described within the standard are expected within the Brazilian Atlantic Domain, but efforts to describe the advertisement call of frogs of the Atlantic are concentrated in non-threatened species. Among the descriptions works, there is a large discrepancy between the information presented, giving preference to the use of abiotic data in this kind of work, to the detriment of biotic data about choir where the songs were recorded. The results point to the need for advancements in the descriptions of the advertisement of endangered species or to those with deficient information on their conservation status in the Atlantic Forest, and also for greater communication between works that describe vocalizations of frogs. It will be important to know about the state of the art of descriptions works of frogs in other Brazilian Domains, and relate this information with knowledge...

Quais relações estabelecidas entre ensino de química, educação ambiental e o enfoque CTS?: um estado da arte de alguns periódicos nacionais

This work presents results of art state that searched articles to bring in its wake the relationship between Teaching of Chemistry (TC), Environmental Education (EE) and the Teaching of Chemistry directed from the Science Technology and Society (STS) standpoint. The research was carried by articles surveying in major magazines Brazilian Environmental Education and a reference in the research magazine of Science Education, being performed a qualitative analysis of those items that were identified. It was noted that little is produced on the subject of interest within this field, in mid-1998 to June 2012. In the articles analyzed did not find a perspective that allied relationship STS and EE, or EE, STS and TC. Nine articles were found in relation EE and TC, and TC and three articles STS, constituting two thematic axes: Relationship between Environmental Education and the Teaching of Chemistry and Relationship between Science and Technology Society and Chemistry Teaching, The discussion was given from the contents that comprised the categories created. The first axis involved: a) Teacher of Chemistry and EA b) Contents of Chemistry and EE, and c) Concepts and practices of EE Chemistry teachers. The second axis of the categories are: a) formative processes and conceptions of chemistry teachers in STS: b) Analysis of TC practice focusing STS. There were works produced by the same authors, who mostly used the same theme in different magazines for publication only changing the perspective of analyzing the results. Finally, a scenario indicates that restricted thematic research and the need to advance with future work

Criopreservação de embriões bovino produzidos in vitro: estado da arte

In the last years, the embryo in vitro production for every domestic species and mainly for bovine has attained a notorius status. This reproductive biotechnical procedure associate with ultrasound-guided ovum pick up (OPU) has been more and more incorporated and spread in our cattle herds, ranking up Brazil already at the top of the list in number of in vitro embryo produced. Some significant advantages provided, such as the possibility of using the premature or pregnant animals oocytes, without necessarily requiring the use of hormonal treatment, to make it possible to generate pregnancy at a shorter period of time, the rationalization in the use of semen and optimization in the use of sexed semen were determinant factors for OPU/IVP to reach this outstanding position. Nevertheless, right now the possibility of IVP embryo cryopreservation, just now is the biggest impediment for maximizing the use of this biotechnology, due to both lack of efficient methods and low laboratory produced embryo cryotolerance. Nowadays, the most used methods of IVP embryo cryopreservation are: slow freezing and vitrification. Traditionally, slow freezing is still the most used methods for in vivo and in vitro produced embryo cryopreservation. However, more recently vitrification - although still not commercially used in large scale - has been presenting satisfactory results in IVP embryo cryopreservation, according to searches