Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients

The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being recognized in Brazilian and French patients, respectively. The GPGR (P) motif was predominant in French but not in Brazilian patients (53.5% vs 31.0%), whereas the GWGR (W) motif was frequent in Brazilian patients (23.0%) and absent in French patients. Three tip motif groups were considered: P, W, and non-P non-W groups. The distribution of HIV-1 isolates into the three groups was significantly different between isolates from Botucatu and from Montpellier (P < 0.001). A higher proportion of CXCR4-using HIV-1 (X4 variants) was observed in the non-P non-W group as compared with the P group (37.5% vs 19.1%), and no X4 variant was identified in the W group (P < 0.001). The higher proportion of X4 variants in the non-P non-W group was essentially observed among the patients from Montpellier, who have been infected with HIV-1 for a longer period of time than those from Botucatu. Among patients from Montpellier, CD4+ cell counts were lower in patients belonging to the non-P non-W group than in those belonging to the P group (24 cells/µL vs 197 cells/µL; P = 0.005). Taken together, the results suggest that variability of the V3 loop tip motif may be related to HIV-1 coreceptor usage and to disease progression. However, as analyzed by a bioinformatic method, the substitution of the V3 loop tip motif of the subtype B consensus sequence with the different tip motifs identified in the present study was not sufficient to induce a change in HIV-1 coreceptor usage.

Geografias do drama humano: leituras do espaço em São Bernardo, de Graciliano Ramos e Pedro Páramo, de Juan Rulfo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

L'Amour dácadent em dramas de Villiers de L'Isle-Adam e Maurice Maeterlinck

Pós-graduação em Estudos Literários - FCLAR

A natureza participante de Eisenstein / Eisenstein’s participant nature

Este artigo analisa alguns ensaios de Eisenstein escritos entre 1945 e 1947, que se encontram na antologia francesa intitulada La non-indifférente nature, de 1976. Fio condutor dos escritos é uma indagação sobre a natureza orgânica da obra de arte, encontrada nas mais variadas manifestações artísticas: em cinema, teatro, literatura, pintura, arquitetura, música. A “organicidade” das obras artísticas decorria do fato de elas serem construídas conforme os elementos estruturais do fenômeno representado: a ligação entre realidade e obra não consistiria numa reprodução de conteúdos, mas na recriação, em todos os níveis formais da obra, da lei dialética que rege a realidade. This paper analyses some essays by Eisenstein written between 1945 and 1947, included in a French anthology of 1976 entiled La non-différente in nature. The guideline of such writings is a quest for the “organic nature” of the work of art, found in the most varied artistic manifestations: cinema, drama, literature, painting, architecture, music. The “organicity” of works of art derived from the that they were built according to the structural elements of the phenomenon represented: the connection between reality and work would not consist of a duplication of contents, but in the recreation, in all the formal levels of the work, of the dialectic law which rules reality.

Geografias do drama humano: leituras do espaço em São Bernardo, de Graciliano Ramos, e Pedro Páramo, de Juan Rulfo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A contribuição do canto para a voz falada do ator

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Polymorphic Sites at the 3 ' Untranslated Region of the HLA-G Gene Are Associated with Differential hla-g Soluble Levels in the Brazilian and French Population

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Crítica em perspectiva semiótica: o caso de Barbara Heliodora

This research aims to analyze, based on the theories of French semiotics (or greimasian), the development of the critical text by Barbara Heliodora and drama criticism, a very popular genre in journalism and therefore of great relevance for scholars in the area. The corpus of this research will analyze nine texts by the author, giving priority to her early career (texts from 1957, 1958 and 1962) and her most recent texts (two from 2007 and one from 2010). The choice for greimasian Semiotics is justified because it is a methodology that provides all the necessary elements for interpretation of textual content and its relationship both in the business of the theater and journalism

Itinerários do bovarismo

According to Sérgio Buarque de Holanda, there is a “thinking addiction" in Brazil that disfigures reviews and creates disadvantages for a better understanding of the real changing of conditions in society. It is in Raízes do Brasil that this "reasoning addiction" is best defined as an "Invincible disenchantment from the view of our real conditions". This definition is supported by the bovarism theory - pouvoir qu`a l`homme de se concevoir autre qu’il n’est - theory formulated by Jules de Gaultier (1858-1942), French homme de lettres and who promoted Nietzsche in France - for this title, he is self intended as a philosopher, which extends the characterization of the individual drama of Flaubertian's character of Madame Bovary for the characterization of nations. Sérgio Buarque de Holanda is not the only author who uses this notion, before him, it was also in Paulo Prado and Lima Barreto and much after him in Celso Furtado and Paulo Eduardo Arantes, to keep with the best known authors. This article aims to show how bovarism is born, what it is meant in the French context of origin and how it acclimatized in Brazilian's intellectual experience, theoretically basing important diagnostics of our society. This is to conduct genetic mapping of a concept which is still strong in the horizon of the decisive clash between national projects that deal with Brazil's peripheral condition.

Pólis vs. Oikos: a investigação do papel feminino no drama grego

This work analyzes the consequences of the intersection between the two spheres polis and oikos. It does so by examining themes present in three plays: Medea, Agamemnon and Lysistrata. The focus of the analysis is the way in which the feminine characters react to conflicts of interests in their respective situations. To fully comprehend which values correspond to which mentioned institution, the work also necessarily investigates the socialization and functions of both genders in fifth-century Athenian society. The analysis of the feminine condition in the creation myth implies the importance of the misogynistic sense of that time, which culminated in the silencing, discrediting, and systemic repression of females. The role of women in society, instilled in all girls starting in early childhood, is to succeed in marriage and domestic permanence. This lies opposite the masculine role, which was focused outside of the family center and to environments relating to war and public life. Matrimony and family, traditional female values, were threatened when overlapping with male interests, such as unavoidable war or social ascension through a different matrimonial bond. Therefore, it is possible to affirm that the opposition evident in the definitions male vs. female indicates that, in certain contexts, the interests of each element cause the conflicts present in the chosen plays