Functional activity of neutrophils and systemic inflammatory response of Down's syndrome patients with periodontal disease

Periodontal disease (PD) is characterized as an inflammatory process that compromises the support and protection of the periodontium. Patients with Down's syndrome (DS) are prone to develop PD. Neutrophils (NE) are the first line of defense against infection and their absence sets the stage for disease. Aim: To compare the activity and function of NE in the peripheral blood from DS patients with and without PD, assisted at the Center for Dental Assistance to Patients with Special Needs affiliated with the School of Dentistry of Araçatuba, Brazil. Methods: Purified NE were collected from peripheral blood of 22 DS patients. NE were used to detect the 5-lypoxigenase (5-LO) expression by RT-PCR. Plasma from peripheral blood was collected to measure tumor necrosis factor-a (TNF-α) and interleukin-8 (IL-8) by ELISA and nitrite (NO 3) using a Griess assay. Results: Data analysis demonstrated that DS patients with PD present high levels of TNF-a and IL-8 when compared with DS patients without PD. However, there was no statistically significant difference in the levels of NO 3 production between the groups. The levels of the inflammatory mediator 5-LO expression increased in DS patients with PD. Conclusions: According with these results, it was concluded that TNF-α and IL-8 are produced by DS patients with PD. Furthermore, DS patients with PD presented high levels of 5-LO expression, suggesting the presence of leukotriene B 4 (LTB 4) in PD, thus demonstrating that the changes in NE function due to the elevation of inflammatory mediators contribute to PD.

Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Inclusão de crianças com Síndrome de Down

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ectrópio palpebral em portador da síndrome de Down e conjuntivite alérgica: Relato de caso

This is a case report of a patient with Down's syndrome with an important mechanical ectropion and elongation of the lower lid related to chronic allergic conjunctivitis, besides cataract and keratoconus. The tarsal strip technique and ressection of redundant and thick conjunctiva was the surgical approach chosen for this case. Functional and cosmetic outcomes were considered satisfactory.

Síndrome de down: situação escolar no ensino fundamental e médio da cidade de Araraquara-SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Verificação da proporção áurea em medidas cefalométricas laterais de indivíduos com síndrome de Down

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Escrita e Síndrome de Down

The project, developed at the Health and Education Studies´ Center, in the Unity of the Science and Philosophy’s College, UNESP, Marilia´s campus, had as goal the development of a study about the appropriation of writing by children with Down ’s syndrome. Five children, from 10 to 13 years old, on different situations of scholar levels, were took part in the project. As research procedure, it was developed weekly pedagogical interventions, based on HistoricalCultural Theory. At the beginning, the group presented different dimensions of approximation with the writing universe. It was observed advances on the graphic representation and on the individual trials of writing. Two childrens began to build small texts, one of the children is on the beginning of the alphabetic writing and two other children continue to present difficulties, getting close of the writing in a very not confortable way, stuck on the scholar formality and a direct mediation to the words constitution is needed.

Notas sobre a apropriação da escrita por crianças com Síndrome de Down

The project, developed at the Health and Education Studies ́ Center, in the Unity of the Science and Philosophy’s College, UNESP, Marilia ́s campus, had as goal the development of a study about the appropriation of writing by children with Down ’s syndrome. Five children, from 10 to 13 years old, on different situations of scholar levels, were took part in the project. As research procedure, it was developed weekly pedagogical interventions, based on Historical-Cultural Theory. At the beginning, the group presented different dimensions of approximation with the writing universe. It was observed advances on the graphic representation and on the individual trials of writing. Two children began to build small texts, one of the children is on the beginning of the alphabetic writing and two other children continue to present difficulties, getting close of the writing in a very not comfortable way, stuck on the scholar formality and a direct mediation to the words constitution is needed.

Aggregatibacter actinomycetemcomitans em pacientes com síndrome de down: influência da condição periodontal e higiene bucal

Patients with Down syndrome have varying degrees of mental retardation, physical and motor, and apparently are more susceptible to infectious diseases. Thus, the present study aimed to evaluate the occurrence of Aggregatibacter actinomycetemcomitans in saliva and subgingival biofilms and above of children and adolescents with Down syndrome and analyze the influence of diet, socioeconomic and cultural factors and periodontal condition. After assessing the socio-economic and behavioral, were collected clinical specimens, which were transported to the laboratory of Microbiology and Immunology FOA-UNESP for detection of microorganisms by molecular method and periodontal conditions were evaluated according to the Periodontal Screening Index and Recording. The control group consisted of individuals without the syndrome. The results were analyzed by chi-square test for proportion analysis of variables with three or more categories, or the Mann-Whitney test. The data analysis of this study showed that the occurrence of A. actinomycetemcomitans ranged from 0.0% to 25.0%, both in the group of patients with Down syndrome, as for the control group and this was not affected by socioeconomic characteristics of the target population, either by oral hygiene standards

Conceito de número: uma contribuição da análise comportamental da cognição

Fundamenta-se o presente estudo na análise comportamental da cognição, cujas formulações permitem compreender o conceito de número como uma rede de relações entre estímulos e/ou entre estímulos e respostas. O desempenho de seis crianças de três a sete anos de idade e uma adolescente portadora da Síndrome de Down foi analisado em uma série de tarefas consideradas pré-requisitos para aprendizagens matemáticas mais complexas. Para isso, foi utilizada uma versão informatizada do procedimento de discriminação condicional em um contexto de matching to sample. As relações presentes, ausentes e as não bem estabelecidas no repertório dos sujeitos foram graficamente representadas em diagramas que configuram-se como que retratos do repertório individual. Tal recurso facilita o planejamento do ensino estratégico de umas poucas relações com vistas à emergência das relações ausentes e/ou o fortalecimento daquelas nas quais o sujeito apresenta desempenho pobre, de modo a completar a rede. A guisa de conjeturas, apresentam-se sugestões de intervenção.