77 resultados para Dose diária recomendada
em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"
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The study of antioxidant has a great interest to biochemistry and medicine, due to of used in the human body as inhibitor to free radical process, which can cause premature aging and degenerative diseases. Furthermore, antioxidant is widely used in food industry that i s used to prevent food deterioration, in fats and oils (autoxidation, known as rancidity). Thereby, the survey data labels of vegetable oils such as soybean one, corn one and sunflower one, it is very important, with this survey data label was possible to verify the antioxidants used on vegetable oils and describe their chemical structure, molecular formula, lethal dose and daily dose by review. Following this review, it was possible to create a website with in formation and description of antioxidants. This database has free access to the public, in order to help the population about these chemicals compounds, and help them to choose the more beneficial food to eat
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Sibutramine is a drug recommended clinically for the treatment of obesity, but there are women that use the drug for maintenance of body weight. Many time this use occur associate to habit of tabagism, being the nicotine the main toxic compound in the cigarette. The goal of study was to evaluate the side effects promoted by sibutramine, associated or not to nicotine, in the reproductive tissue of adult female rats. Wistar animals (n = 30), were distributed in the groups: a) Control A (0.3 mL of distilled water; oral); b) Sibutramine (15 mg/kg of body weight; oral); c) Control B (0.3 mL of saline solution; intraperitoneal); d) Nicotine (4.0 mg/kg of body weight; intraperitoneal); e) sibutramine + nicotine. The treatments were conducted during 30 consecutive days (single dose, daily). Sibutramine, associated or not to nicotine, affected the folliculogenesis and luteogenesis. There were significant alterations (p<0.05) in the thickness of uterine layers, considerate each treatment. In conclusion, the administration isolated of sibutramine or nicotine promoted deleterious effects in the reproductive tissues of female rats and these effects were potential in the group that received both drugs.
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Sibutramine is a drug recommended clinically for the treatment of obesity, but there are women that use the drug for maintenance of body weight. Many time this use occur associate to habit of tabagism, being the nicotine the main toxic compound in the cigarette. The goal of study was to evaluate the side effects promoted by sibutramine, associated or not to nicotine, in the reproductive tissue of adult female rats. Wistar animals (n =30), were distributed in the groups: a) Control A (0.3 mL of distilled water; oral); b) Sibutramine (15 mg/kg of body weight; oral); c) Control B (0.3 mL of saline solution; intraperitoneal); d) Nicotine (4.0 mg/kg of body weight; intraperitoneal); e) sibutramine + nicotine. The treatments were conducted during 30 consecutive days (single dose, daily). Sibutramine, associated or not to nicotine, affected the folliculogenesis and luteogenesis. There were significant alterations (p<0.05) in the thickness of uterine layers, considerate each treatment. In conclusion, the administration isolated of sibutramine or nicotine promoted deleterious effects in the reproductive tissues of female rats and these effects were potential in the group that received both drugs.
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O experimento foi conduzido em casa de vegetação telada na FCAV/Unesp campus Jaboticabal-SP, durante o período de novembro de 2005 a janeiro de 2007. Conduziu-se este estudo, com o objetivo de avaliar componentes do desenvolvimento e do estado nutricional de mudas de laranjeira Valência (Citrus sinensis Osbeck), enxertadas sobre limoeiro Cravo (Citrus limonia Osbeck), em função de doses de nitrogênio, fósforo e potássio. O delineamento experimental foi inteiramente casualizado, em esquema fatorial 3³ + 1, sendo 3 fatores (nitrogênio, fósforo e potássio - NPK), 3 doses e uma testemunha (sem adubação), com 3 repetições. A unidade experimental foi representada por uma muda de laranjeira por sacola com 5 dm³ com 2,5 kg de substrato casca de Pinus spp. e vermiculita. Os tratamentos foram constituídos pela metade, uma vez e duas vezes a dose padrão recomendada, de 4.590; 920 e 4.380 mg sacola-1, de N, P e K, respectivamente. As adubações com N e K foram realizadas via fertirrigações três vezes por semana e o P foi adicionado ao substrato antes do replantio das mudas. Aos 424 dias após o transplantio, as plantas foram subdivididas em raízes e parte aérea para determinação da massa da matéria seca, altura, área foliar, diâmetro do caule e conteúdo de nutrientes. A adubação com N, P e K proporcionou maior desenvolvimento e maior acúmulo desses macronutrientes na parte aérea e nas raízes das mudas de laranjeira Valência, sobre limoeiro Cravo. Houve adequado desenvolvimento das plantas com a metade da dose recomendada de N, P e K pela literatura, aproximadamente de 918, 184 e 876 mg dm-3, respectivamente.
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Fertirrigation with phosphoric acid has been considered as an option to avoid drips from clogging. In some cases, this acid cause soil acidification and it can be substituted bypotassium hydroxide. This study had the objective of evaluating the effects of different phosphoric acid and potassium hydroxide doses, applied via fertirrigation, on soil fertility, plant nutrition and lettuce yield, compared to the conventional fertilization system. The experiment was carried out in greenhouse, in the College of Agricultural Sciences, FCA/UNESP, Botucatu-SP-Brazil. The experimental design was the completely randomized block, with 6 treatments and 4 replications. Treatments consisted of the combinations of doses (25% and 50% of the recommended complete dose for the lettuce) and application ofcomplete dose (100%) of phosphorus (P) and potassium (K) applied via fertirrigation, and a control (conventional fertilization system). The results showed that P and K availability in soil and nutrient concentration in plants were affected by treatments. Low phosphorus and potassium doses, applied via fertirrigation, were not efficient for the appropriate development of lettuce plants. The results showed that agronomic characteristics and commercial lettuce were affected by doses and application systems, especially the treatment with application of P and K full dose fertirrigation.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Medicina Veterinária - FMVZ
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Pediatria - FMB
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Engenharia e Ciência de Alimentos - IBILCE
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The present study aimed to evaluate cardiac and lipoperoxidation markers in horses subjected to low intensity and long duration (TLD) exercise test, before and after vitamin E supplementation. For this purpose, 10 horses were used, subjecting them to the first TLD with a workload based on individual maximal oxygen uptake (VO2max). Then, horses received vitamin E (dl-alpha-tocopherol) during 59 days at a daily oral dose of 1,000IU, and thereafter they performed a second TLD with the same protocol as the first. Blood samples were collected to determine plasma malondialdehyde (MDA) as an index of lipoperoxidation, serum cardiac troponin I (cTnI) and creatine kinase MB isoenzyme (CK-MB) as cardiac markers. As a result of the exercise, there was no significant increase in MDA or cTnI, but serum CK-MB increased suggesting myocardial stress. The supplementation was able to minimize reactive oxygen species production, as evidenced by lower concentrations of MDA at all times evaluated, but it didn't cause protective effect on the myocardium. It was concluded that the low intensity and long duration exercise promoted light myocardial stress in horses and vitamin E supplementation reduced lipoperoxidation.