128 resultados para Desenvolvimento de Sistemas de informação

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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DEVELOPMENT of LIQUID-CRYSTALLINE SYSTEMS USING SILICON GLYCOL COPOLYMER and POLYETHER FUNCTIONAL SILOXANE. For the construction of the phase diagrams, the method of the aqueous titration was used. There were prepared 5 ternary diagrams, varying the surfactant and the oil phase. The liquid-crystalline phases were identified by polarized light microscopy. The formulations prepared with silicon glycol copolymer, polyether functional siloxane (PFS) and water (S(1)) and with diisopropyl adipate, PFS and water (S(4)) presented liquid-crystalline phases with lamellar arrangement. Moreover, after 15 days in hot oven (37 degrees C), the formulations presented hexagonal arrangement, evidencing the influence of the temperature in the organization of the system.

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As occurs with a number of drugs, the bioavailability of amphotericin B (AmB) used to treat fungal infections by the ocular route remains a great challenge to research scientists. In fact, the poor bioavailability of AmB is due mainly to the corneal barrier, which leads to a precorneal loss and consequent decrease in the absorption of this drug into the intraocular tissues. The toxicity associated with this molecule, together with its poor ability to penetrate the intact corneal epithelium, also represents a major drawback to its clinical use. New effective and safe drug vehicles for ocular delivery of AmB are therefore urgently needed. Microemulsions (MEs) seem to be an interesting system, owing to their transparent appearance, thermodynamic stability and favorable viscosity. Knowledge of the process of formation of AmB-containing MEs, as well as a good understanding of the physical chemistry of such systems, would provide reliable information on the best conditions for the use of these systems as eye drops. The goal of this research was thus to make an approach to this subject by reviewing the main studies on the use of MEs as delivery systems for AmB in topical eye treatment.

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Pós-graduação em Ciências Farmacêuticas - FCFAR

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Pós-graduação em Ciências Farmacêuticas - FCFAR

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Pós-graduação em Engenharia Mecânica - FEG

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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O objetivo deste trabalho foi identificar e mapear áreas suscetíveis a movimentos de massa, por meio das geotecnologias, no município de Várzea Paulista (SP). Para o propósito, foram utilizados os mapas de declividade, geológico, geomorfológico e de uso e ocupação da terra, que foram sobrepostos por meio da Análise Multicritério no SIG ArcGIS. Cada tema recebeu seu peso de influência para deflagração de tais processos e como resultado final foi obtido o mapa de suscetibilidade a movimentos de massa do município em questão. Paralelamente foi elaborado o estudo da orientação de vertentes, para determinação daquelas que apresentam maiores riscos em comparação com os dados coletados em campo. Constatou-se que existem muitas áreas ocupadas dentro do município que carecem de monitoramento do Poder Público, principalmente nos meses chuvosos, pois se encontram em locais frágeis do ponto de vista geológico-geomorfológico.

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The purpose of this article is to identify the contributions of Information Systems (IS) for environmental management practices, as well as the opportunities and challenges in this relation. Thus, we performed two case studies with Brazilian enterprises certified ISO 14001, by conducting interviews, document analysis and direct observation. As results, we present the identification of the main contributions of information systems for environmental management practices in the studied cases, the verification that a more advanced stage regarding IS is a factor that implies a more effective contribution, besides finding challenges and opportunities in this relation. The main contribution of this research consists of the presentation of a framework that identifies the support of information systems for environmental practices.

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Pós-graduação em Química - IQ