Inclusion complex of piroxicam with beta-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effect

Topical formulations of piroxicam were evaluated by determination of their in vitro release and in vivo anti-inflammatory effect. The in vitro release assay demonstrated that the microemulsion (ME) systems provided a reservoir effect for piroxicam release. However, the incorporation of the ME into carboxyvinilic gel provoked a greater reduction in the release of piroxicam than the ME system alone. Anti-inflammatory activity was carried out by the cotton pellet granuloma inhibition bioassay. Topical anti-inflammatory effect of the piroxicam inclusion complex/ME contained in carboxyvinilic gel showed significant inhibition of the inflammation process (36.9%, P < 0.05). Subcutaneous administration of the drug formulations showed a significant effect on the inhibition of inflammation, 68.8 and 70.5%, P <0.05, when the piroxicam was incorporated in ME and in the combined system beta -cyclodextrin (B-CD)/ME, respectively, relative to the buffered piroxicam (42.2%). These results demonstrated that the ME induced prolonged effects, providing inhibition of the inflammation for 9 days after a single dose administration. (C) 2001 Elsevier B.V. B.V. All rights reserved.

Tratamento de águas residuárias de suinocultura em reatores anaeróbios horizontais seguidos de reator aeróbio em batelada sequencial

Avaliou-se o desempenho de um sistema combinado anaeróbio-aeróbio para o tratamento de águas residuárias de suinocultura, com concentrações médias de sólidos suspensos totais (SST) de 18.624 e 11.395 mg L-1. Foram utilizados quatro reatores anaeróbios horizontais com volume total de 49,5 L cada, um com manta de lodo (RAHML) e três de leito fixo (RAHLF), instalados em série e seguidos de um reator aeróbio operado em batelada sequencial (RBS) com volume total de 339 L e com alimentação contínua. Nos RAHLF, foram utilizados como meios suporte de anéis de bambu, anéis plásticos de eletroduto corrugado e anéis de bucha (Luffa cillyndrica), respectivamente. Os tempos de detenção hidráulica (TDH) e as cargas orgânicas volumétricas (COV) aplicadas no RAHML foram de 12 e 10 h e 53 e 61 g DQO (L d)-1, respectivamente. O RBS foi operado com ciclo de 24 h e COV de 0,34 e 0,50 g DQO (L d)-1. As eficiências médias de remoção de DQOtotal e SST para o conjunto de reatores anaeróbios horizontais, em série, foram de 96 e 99%, e de 96 e 95%, respectivamente. As maiores produções volumétricas de metano ocorreram nos RAHLF, com valores médios de até 0,744 m³ CH4 (m³ reator d)-1. A inclusão do RBS permitiu melhorar a qualidade do efluente e a estabilidade do sistema de tratamento, atingindo eficiências de remoção de DQOtotal e SST de 99 e 99%, e de 98 e 99%, respectivamente. No RBS, ocorreu nitrificação e desnitrificação, com remoções de N-amoniacal de até 65%.

Tratamento de águas residuárias de suinocultura em reatores anaeróbios horizontais seguidos de reator em bateladas sequenciais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação de sistema composto por reatores anaeróbios e aeróbio para tratmento de águas residuárias de suinocultura

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação do processo de contaminação e remediação de água subterrânea por hidrocarbonetos

Pós-graduação em Engenharia Civil e Ambiental - FEB

Emprego de carvão ativado e resinas de troca ionica na remoção de substâncias orgânicas contaminantes do alcool etílico

This work had with objective to characterize and evaluate the performance of the combined system, involving activated charcoal and ionic exchange resins in the removal of substances organic contaminating of the ethyl alcohol from the fermentation of the cassava starch. To testing was used ethyl alcohol PA 96 oGL, conductivity of 0.90 μS/cm at 25 oC, acidity of 60 mg/L and Barbet test of 43 minutes at 15 oC. The contaminated alcohol was composed of ethyl alcohol additive of higher alcohols, organic acids, ester, diol, aldehydes, ketone and ether. Contaminated alcohol was added 2% activated charcoal and after the adsorption isotherm in ionic exchange resins was tested. The adsorption with activated charcoal was performed in a Water Bath at 30 oC for one hour and a half and shaking. Already adsorption ionic exchange columns occurred at room temperature on columns of 93,4 cm in filling height and diameter of 2.29 cm, for flows of 180 mL/min and 90 mL/min. Samples were collected in the tests with charcoal and with each one of the resins and the following analyses were performed: conductivity, acidity and Barbet test. The medium values for conductivity, acidity and Barbet test after the adsorption in charcoal and cation and anion resins were respectively: conductivity was 240; 354 and 465 μS/cm to 25 oC; acidity of 1.081; 1.103 and 1.062 mg/L and the Barbet test was 21; 20 and 9 minutes to 15 oC. It was observed that the addition of 2% of activated charcoal and the permanence in the columns of adsorption was not sufficient to remove the organic substances contaminating of the ethyl alcohol.

Stochastic simulation of time-series models combined with geostatistics to predict water-table scenarios in a Guarani Aquifer System outcrop area, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Combined D0 measurements constraining the CP-violating phase and width difference in the B-s(0) system

We combine the D0 measurement of the width difference between the light and heavy B-s(0) mass eigenstates and of the CP-violating mixing phase determined from the time-dependent angular distributions in the B-s(0)-> J/psi phi decays along with the charge asymmetry in semileptonic decays also measured with the D0 detector. With the additional constraint from the world average of the flavor-specific B-s(0) lifetime, we obtain Delta Gamma(s)equivalent to(Gamma(L)-Gamma(H))=0.13 +/- 0.09 ps(-1) and vertical bar phi(s)vertical bar=0.70(-0.47)(+0.39) or Delta Gamma(s)=-0.13 +/- 0.09 ps(-1) and vertical bar phi(s)vertical bar=2.44(-0.39)(+0.47). The data sample corresponds to an integrated luminosity of 1.1 fb(-1) accumulated with the D0 detector at the Fermilab Tevatron Collider.

Economic and technical feasibility study of a combined-cycle cogeneration system associated with cellulose plants

In this paper, is presented an economical and technical feasibility study of a combined cycle cogeneration system proposed to be used in a pulp plant located in Brazil, where around 95% of country's pulp production is done by the use of Kraft Process. This process allows the use of black liquor and other by-products as fuel. This study is based upon actual data from a pulp plant with a daily production of 1000 tons., that generates part of the energy demanded by the process in a conventional cogeneration system with condensing steam turbine and two extractions. The addition of a gas turbine was studied to compare electricity production level and its related costs between original system and the new one, considering that the former can use industrial by-products and firewood as fuel, when required. Several parameters related to electric generation systems operation and production costs were studied. The use of natural gas in the combined cycle, in comparison with the use of firewood in the conventional system was studied. The advantages of natural gas fuel are highlighted. The surplus availability and the electricity generation costs are presented as a function of pulp and black liquor production.

Crop sequences in no-tillage system: effects on soil fertility and soybean, maize and rice yield

Os resíduos vegetais das culturas, ao se decomporem, alteram os atributos químicos do solo e, como consequência, influenciam a produtividade das culturas em sucessão. O objetivo deste trabalho foi avaliar os atributos químicos do solo e a produtividade das culturas de soja, milho e arroz, cultivadas no verão, em sucessão a culturas de inverno em semeadura direta. O experimento foi realizado em Jaboticabal-SP (48 ° 18 ' 58 '' W e 21 ° 15 ' 22 '' S), em um Latossolo Vermelho eutrófico. O delineamento experimental foi em blocos ao acaso, no esquema em faixas, com três repetições. Os tratamentos foram constituídos pela combinação de quatro sequências de culturas de verão (monoculturas de milho e soja e rotações soja/milho e arroz/feijão/algodão) com sete culturas de inverno (milho, girassol, nabo forrageiro, milheto, guandu, sorgo e crotalária). Os cultivos iniciaram-se em 2002. Após o manejo das culturas de inverno e antes da semeadura das culturas de verão do ano agrícola 2006/2007, foram coletadas amostras de solo nas camadas de 0-2,5; 2,5-5,0; 5-10; 10-20; e 20-30 cm. Nas amostras de solo, foram determinados: teores de matéria orgânica, pH, teores de P (resina), K, Ca e Mg trocáveis e acidez potencial (H + Al). As sequências de verão rotação soja/milho e milho em monocultura proporcionaram no solo menores teores de matéria orgânica na camada de 0-10 cm e de P do solo na camada de 0-20 cm. Na sequência de verão arroz/feijão/algodão, maiores teores de K foram proporcionados pelas culturas de inverno crotalária e nabo forrageiro, na camada de 0-10 cm, e milheto, na de 0-2,5 cm. Crotalária, milheto, nabo forrageiro e sorgo, cultivados no inverno, proporcionaram maiores teores de matéria orgânica no solo na camada de 0-30 cm. Maiores teores de P no solo foram proporcionados pela crotalária, na camada de 0-2,5 cm, e pelo nabo forrageiro, na de 0-5 cm. Maiores produtividades de soja, como monocultura de verão, foram obtidas após nabo forrageiro e crotalária e, quando em rotação com milho no verão, após nabo forrageiro, crotalária e milheto. Maiores produtividades de milho foram obtidas após nabo forrageiro, milheto e guandu, e menor produtividade de arroz foi obtida após sorgo.

Sward canopy structure and performance of beef heifers under supplementation in Brachiaria brizantha cv. Marandu pastures maintained with three grazing intensities in a continuous stocking system

The objective of this study was to assess the sward canopy structure of Brachiaria brizantha cv. Marandu pastures maintained in three grazing intensities under continuous stocking system during the rainy season, along with the behavior and performance of grazing beef heifers supplemented with mineral salt or an energy/protein supplement. Three levels of forage allowance were assessed: 2.0, 2.5 and 3.0 kg of forage/kg of live weight, combined with two supplements (ad libitum mineral salt, and an energy/protein supplement at 0.3% of live weight/day, supplied daily). The experiment was designed as a randomized block study with two replications. The supplements did not influence the variables related to the canopy structure. Canopy height was greater at higher forage allowances during the late summer and early fall. Similarly, the stem mass was greater in pastures with higher forage allowances. Animals fed protein supplement spent less time grazing than animals supplemented with mineral salt. Stocking rate was higher in pastures with lower forage allowance levels, which increased the live weight gain per grazing area. Daily weight gain did not vary according to the forage allowance levels. The use of an energy/protein supplement did not affect the stocking rate; however, it increased individual live weight gain and live weight gain per grazing area compared with mineral salt supplementation. The use of energy/protein supplements is an efficient alternative to enhance animal performance and production under grazing systems during the rainy season

A low-cost 3D reconstruction system using a single-shot projection of a pattern matrix

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Subconjunctival Delivery of Antibiotics in a Controlled-Release System A Novel Anti-infective Prophylaxis Approach for Cataract Surgery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of the Single or Combined Administration of Cocaine and Testosterone on Cardiovascular Function and Baroreflex Activity in Unanesthetized Rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Combined Pool/Bilateral Short-Term Hydrothermal Scheduling Model for Day-Ahead Energy Markets

This paper proposes a combined pool/bilateral short term hydrothermal scheduling model (PDC) for the context of the day-ahead energy markets. Some innovative aspects are introduced in the model, such as: i) the hydraulic generation is optimized through the opportunity cost function proposed; ii) there is no decoupling between physical and commercial dispatches, as is the case today in Brazil; iii) interrelationships between pool and bilateral markets are represented through a single optimization problem; iv) risk exposures related to future deficits are intrinsically mitigated; v) the model calculates spot prices in an hourly basis and the results show a coherent correlation between hydrological conditions and calculated prices. The proposed PDC model is solved by a primal-dual interior point method and is evaluated by simulations involving a test system. The results are focused on sensitivity analyses involving the parameters of the model, in such a way to emphasize its main modeling aspects. The results show that the proposed PDC provides a conceptual means for short term price formation for hydrothermal systems.